The effect of tannic acid on membrane enzymes and on permeability
1. 1. The effects of tannic acid on ATPases and non-specific phosphatases has been studied. 2. 2. The ATPases of a rat brain microsomal preparation showed a simple inhibition comparable with the effect found with erythrocyte cholinesterase. Tannic acid had only a small or no action on the Mg 2+−acti...
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| Veröffentlicht in: | Comparative biochemistry and physiology. A, Comparative physiology Comparative physiology, 1971-08, Vol.39 (4), p.583-598 |
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| container_title | Comparative biochemistry and physiology. A, Comparative physiology |
| container_volume | 39 |
| creator | Radcliffe, M.A. Duncan, C.J. Bowler, K. |
| description | 1.
1. The effects of tannic acid on ATPases and non-specific phosphatases has been studied.
2.
2. The ATPases of a rat brain microsomal preparation showed a simple inhibition comparable with the effect found with erythrocyte cholinesterase. Tannic acid had only a small or no action on the Mg
2+−activated surface apyrase and p-nitrophenyl phosphatase activities of erythrocytes.
3.
3. The Mg
2+− and Na
+−K
+−Mg
2+−ATPase activities of erythrocyte ghosts, however, were markedly activated by low concentrations of tannic acid, both when this agent was applied to the ghosts directly and when applied to the erythrocytes prior to haemolysis.
4.
4. Although tannic acid is known to reduce erythrocyte anion permeability at low concentrations, it was found to have relatively little effect, either on passive cation permeability or on active efflux of
22Na.
5.
5. The possible implications of these ATPase enzyme systems in the control of ion permeability and of the disc shape of erythrocytes are discussed. |
| doi_str_mv | 10.1016/0300-9629(71)90180-0 |
| format | Article |
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1. The effects of tannic acid on ATPases and non-specific phosphatases has been studied.
2.
2. The ATPases of a rat brain microsomal preparation showed a simple inhibition comparable with the effect found with erythrocyte cholinesterase. Tannic acid had only a small or no action on the Mg
2+−activated surface apyrase and p-nitrophenyl phosphatase activities of erythrocytes.
3.
3. The Mg
2+− and Na
+−K
+−Mg
2+−ATPase activities of erythrocyte ghosts, however, were markedly activated by low concentrations of tannic acid, both when this agent was applied to the ghosts directly and when applied to the erythrocytes prior to haemolysis.
4.
4. Although tannic acid is known to reduce erythrocyte anion permeability at low concentrations, it was found to have relatively little effect, either on passive cation permeability or on active efflux of
22Na.
5.
5. The possible implications of these ATPase enzyme systems in the control of ion permeability and of the disc shape of erythrocytes are discussed.</description><identifier>ISSN: 0300-9629</identifier><identifier>DOI: 10.1016/0300-9629(71)90180-0</identifier><identifier>PMID: 4398982</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>active transport ; Adenosine Diphosphate - metabolism ; Adenosine Triphosphatases - antagonists & inhibitors ; adenosinetriphosphatases ; Animals ; anion permeability ; ATPases ; Biological Transport, Active - drug effects ; Brain - cytology ; Brain - drug effects ; Brain - enzymology ; cation permeability ; Cell Membrane - drug effects ; Cell Membrane - enzymology ; Cell Membrane Permeability - drug effects ; cholinesterase ; Cholinesterase Inhibitors - pharmacology ; Enzyme Activation ; Erythrocytes ; Erythrocytes - cytology ; Erythrocytes - drug effects ; Erythrocytes - enzymology ; Erythrocytes - metabolism ; Kinetics ; Magnesium - pharmacology ; Microsomes - drug effects ; Microsomes - enzymology ; Nitrophenols ; p-nitrophenyl phosphatase ; permeability ; Phosphoric Monoester Hydrolases ; Potassium - pharmacology ; Rats ; red blood cells ; Sodium - metabolism ; Sodium - pharmacology ; Sodium Isotopes ; Swine ; tannic acid ; Tannins - pharmacology</subject><ispartof>Comparative biochemistry and physiology. A, Comparative physiology, 1971-08, Vol.39 (4), p.583-598</ispartof><rights>1971</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c272t-1fbbe68c1db3299ad4e4441a94d49c7c49e8028183bd86ab1a8272ac97d558be3</citedby><cites>FETCH-LOGICAL-c272t-1fbbe68c1db3299ad4e4441a94d49c7c49e8028183bd86ab1a8272ac97d558be3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4398982$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Radcliffe, M.A.</creatorcontrib><creatorcontrib>Duncan, C.J.</creatorcontrib><creatorcontrib>Bowler, K.</creatorcontrib><title>The effect of tannic acid on membrane enzymes and on permeability</title><title>Comparative biochemistry and physiology. A, Comparative physiology</title><addtitle>Comp Biochem Physiol A Comp Physiol</addtitle><description>1.
1. The effects of tannic acid on ATPases and non-specific phosphatases has been studied.
2.
2. The ATPases of a rat brain microsomal preparation showed a simple inhibition comparable with the effect found with erythrocyte cholinesterase. Tannic acid had only a small or no action on the Mg
2+−activated surface apyrase and p-nitrophenyl phosphatase activities of erythrocytes.
3.
3. The Mg
2+− and Na
+−K
+−Mg
2+−ATPase activities of erythrocyte ghosts, however, were markedly activated by low concentrations of tannic acid, both when this agent was applied to the ghosts directly and when applied to the erythrocytes prior to haemolysis.
4.
4. Although tannic acid is known to reduce erythrocyte anion permeability at low concentrations, it was found to have relatively little effect, either on passive cation permeability or on active efflux of
22Na.
5.
5. The possible implications of these ATPase enzyme systems in the control of ion permeability and of the disc shape of erythrocytes are discussed.</description><subject>active transport</subject><subject>Adenosine Diphosphate - metabolism</subject><subject>Adenosine Triphosphatases - antagonists & inhibitors</subject><subject>adenosinetriphosphatases</subject><subject>Animals</subject><subject>anion permeability</subject><subject>ATPases</subject><subject>Biological Transport, Active - drug effects</subject><subject>Brain - cytology</subject><subject>Brain - drug effects</subject><subject>Brain - enzymology</subject><subject>cation permeability</subject><subject>Cell Membrane - drug effects</subject><subject>Cell Membrane - enzymology</subject><subject>Cell Membrane Permeability - drug effects</subject><subject>cholinesterase</subject><subject>Cholinesterase Inhibitors - pharmacology</subject><subject>Enzyme Activation</subject><subject>Erythrocytes</subject><subject>Erythrocytes - cytology</subject><subject>Erythrocytes - drug effects</subject><subject>Erythrocytes - enzymology</subject><subject>Erythrocytes - metabolism</subject><subject>Kinetics</subject><subject>Magnesium - pharmacology</subject><subject>Microsomes - drug effects</subject><subject>Microsomes - enzymology</subject><subject>Nitrophenols</subject><subject>p-nitrophenyl phosphatase</subject><subject>permeability</subject><subject>Phosphoric Monoester Hydrolases</subject><subject>Potassium - pharmacology</subject><subject>Rats</subject><subject>red blood cells</subject><subject>Sodium - metabolism</subject><subject>Sodium - pharmacology</subject><subject>Sodium Isotopes</subject><subject>Swine</subject><subject>tannic acid</subject><subject>Tannins - pharmacology</subject><issn>0300-9629</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1971</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kElPwzAQhX0AlVL4ByDlhOAQ8MROYl-QqopNqsSlnC0vE2HUJMVOkcqvx13UI6eR3rw3y0fIFdB7oFA9UEZpLqtC3tZwJykImtMTMj7KZ-Q8xi9KKTAoR2TEmRRSFGMyXXxihk2Ddsj6Jht013mbaetd1ndZi60JukuO7nfTYsx0t9NXGFrUxi_9sLkgp41eRrw81An5eH5azF7z-fvL22w6z21RF0MOjTFYCQvOsEJK7ThyzkFL7ri0teUSBS0ECGacqLQBLVJOW1m7shQG2YTc7OeuQv-9xjio1keLy2W6r19HJQDKSjKWjHxvtKGPMWCjVsG3OmwUULWlpbZY1BaLqkHtaCVpQq4P89emRXcMHVCl_uO-j-nJH49BReuxs-h8SPSU6_3_C_4AjjR6VQ</recordid><startdate>19710801</startdate><enddate>19710801</enddate><creator>Radcliffe, M.A.</creator><creator>Duncan, C.J.</creator><creator>Bowler, K.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19710801</creationdate><title>The effect of tannic acid on membrane enzymes and on permeability</title><author>Radcliffe, M.A. ; Duncan, C.J. ; Bowler, K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c272t-1fbbe68c1db3299ad4e4441a94d49c7c49e8028183bd86ab1a8272ac97d558be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1971</creationdate><topic>active transport</topic><topic>Adenosine Diphosphate - metabolism</topic><topic>Adenosine Triphosphatases - antagonists & inhibitors</topic><topic>adenosinetriphosphatases</topic><topic>Animals</topic><topic>anion permeability</topic><topic>ATPases</topic><topic>Biological Transport, Active - drug effects</topic><topic>Brain - cytology</topic><topic>Brain - drug effects</topic><topic>Brain - enzymology</topic><topic>cation permeability</topic><topic>Cell Membrane - drug effects</topic><topic>Cell Membrane - enzymology</topic><topic>Cell Membrane Permeability - drug effects</topic><topic>cholinesterase</topic><topic>Cholinesterase Inhibitors - pharmacology</topic><topic>Enzyme Activation</topic><topic>Erythrocytes</topic><topic>Erythrocytes - cytology</topic><topic>Erythrocytes - drug effects</topic><topic>Erythrocytes - enzymology</topic><topic>Erythrocytes - metabolism</topic><topic>Kinetics</topic><topic>Magnesium - pharmacology</topic><topic>Microsomes - drug effects</topic><topic>Microsomes - enzymology</topic><topic>Nitrophenols</topic><topic>p-nitrophenyl phosphatase</topic><topic>permeability</topic><topic>Phosphoric Monoester Hydrolases</topic><topic>Potassium - pharmacology</topic><topic>Rats</topic><topic>red blood cells</topic><topic>Sodium - metabolism</topic><topic>Sodium - pharmacology</topic><topic>Sodium Isotopes</topic><topic>Swine</topic><topic>tannic acid</topic><topic>Tannins - pharmacology</topic><toplevel>online_resources</toplevel><creatorcontrib>Radcliffe, M.A.</creatorcontrib><creatorcontrib>Duncan, C.J.</creatorcontrib><creatorcontrib>Bowler, K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Comparative biochemistry and physiology. A, Comparative physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Radcliffe, M.A.</au><au>Duncan, C.J.</au><au>Bowler, K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of tannic acid on membrane enzymes and on permeability</atitle><jtitle>Comparative biochemistry and physiology. A, Comparative physiology</jtitle><addtitle>Comp Biochem Physiol A Comp Physiol</addtitle><date>1971-08-01</date><risdate>1971</risdate><volume>39</volume><issue>4</issue><spage>583</spage><epage>598</epage><pages>583-598</pages><issn>0300-9629</issn><abstract>1.
1. The effects of tannic acid on ATPases and non-specific phosphatases has been studied.
2.
2. The ATPases of a rat brain microsomal preparation showed a simple inhibition comparable with the effect found with erythrocyte cholinesterase. Tannic acid had only a small or no action on the Mg
2+−activated surface apyrase and p-nitrophenyl phosphatase activities of erythrocytes.
3.
3. The Mg
2+− and Na
+−K
+−Mg
2+−ATPase activities of erythrocyte ghosts, however, were markedly activated by low concentrations of tannic acid, both when this agent was applied to the ghosts directly and when applied to the erythrocytes prior to haemolysis.
4.
4. Although tannic acid is known to reduce erythrocyte anion permeability at low concentrations, it was found to have relatively little effect, either on passive cation permeability or on active efflux of
22Na.
5.
5. The possible implications of these ATPase enzyme systems in the control of ion permeability and of the disc shape of erythrocytes are discussed.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>4398982</pmid><doi>10.1016/0300-9629(71)90180-0</doi><tpages>16</tpages></addata></record> |
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| identifier | ISSN: 0300-9629 |
| ispartof | Comparative biochemistry and physiology. A, Comparative physiology, 1971-08, Vol.39 (4), p.583-598 |
| issn | 0300-9629 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | active transport Adenosine Diphosphate - metabolism Adenosine Triphosphatases - antagonists & inhibitors adenosinetriphosphatases Animals anion permeability ATPases Biological Transport, Active - drug effects Brain - cytology Brain - drug effects Brain - enzymology cation permeability Cell Membrane - drug effects Cell Membrane - enzymology Cell Membrane Permeability - drug effects cholinesterase Cholinesterase Inhibitors - pharmacology Enzyme Activation Erythrocytes Erythrocytes - cytology Erythrocytes - drug effects Erythrocytes - enzymology Erythrocytes - metabolism Kinetics Magnesium - pharmacology Microsomes - drug effects Microsomes - enzymology Nitrophenols p-nitrophenyl phosphatase permeability Phosphoric Monoester Hydrolases Potassium - pharmacology Rats red blood cells Sodium - metabolism Sodium - pharmacology Sodium Isotopes Swine tannic acid Tannins - pharmacology |
| title | The effect of tannic acid on membrane enzymes and on permeability |
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