Half-life prediction in unstable renal function: its utility in therapeutic drug monitoring and theoretical and practical considerations

A simple equation is derived to describe the changes in drug elimination half-life (t1/2) in correspondence to the changes in renal function (as measured by creatinine clearance). This equation can be utilized to predict the t1/2 at any time following an initial period in patients with unstable rena...

Ausführliche Beschreibung