Half-life prediction in unstable renal function: its utility in therapeutic drug monitoring and theoretical and practical considerations
A simple equation is derived to describe the changes in drug elimination half-life (t1/2) in correspondence to the changes in renal function (as measured by creatinine clearance). This equation can be utilized to predict the t1/2 at any time following an initial period in patients with unstable rena...
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| Veröffentlicht in: | Therapeutic drug monitoring 1984-01, Vol.6 (2), p.148-152 |
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| container_title | Therapeutic drug monitoring |
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| creator | Chow, M S |
| description | A simple equation is derived to describe the changes in drug elimination half-life (t1/2) in correspondence to the changes in renal function (as measured by creatinine clearance). This equation can be utilized to predict the t1/2 at any time following an initial period in patients with unstable renal function provided that the initial t1/2 and renal function corresponding to each period are known. The clinical application of this equation in predicting 21 serum gentamicin concentrations (SGC) was evaluated in patients with unstable renal function. Excellent correlation (coefficient of determination, r2 = 0.88) between the predicted and measured SGC was obtained. |
| doi_str_mv | 10.1097/00007691-198406000-00003 |
| format | Article |
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This equation can be utilized to predict the t1/2 at any time following an initial period in patients with unstable renal function provided that the initial t1/2 and renal function corresponding to each period are known. The clinical application of this equation in predicting 21 serum gentamicin concentrations (SGC) was evaluated in patients with unstable renal function. Excellent correlation (coefficient of determination, r2 = 0.88) between the predicted and measured SGC was obtained.</description><identifier>ISSN: 0163-4356</identifier><identifier>EISSN: 1536-3694</identifier><identifier>DOI: 10.1097/00007691-198406000-00003</identifier><identifier>PMID: 6740732</identifier><identifier>CODEN: TDMODV</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Bacterial Infections - blood ; Bacterial Infections - drug therapy ; Biological and medical sciences ; Creatinine - blood ; General pharmacology ; Gentamicins - blood ; Gentamicins - metabolism ; Gentamicins - therapeutic use ; Half-Life ; Humans ; Kidney - physiopathology ; Kinetics ; Medical sciences ; Metabolic Clearance Rate ; Models, Biological ; Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions ; Pharmacology. 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This equation can be utilized to predict the t1/2 at any time following an initial period in patients with unstable renal function provided that the initial t1/2 and renal function corresponding to each period are known. The clinical application of this equation in predicting 21 serum gentamicin concentrations (SGC) was evaluated in patients with unstable renal function. Excellent correlation (coefficient of determination, r2 = 0.88) between the predicted and measured SGC was obtained.</description><subject>Bacterial Infections - blood</subject><subject>Bacterial Infections - drug therapy</subject><subject>Biological and medical sciences</subject><subject>Creatinine - blood</subject><subject>General pharmacology</subject><subject>Gentamicins - blood</subject><subject>Gentamicins - metabolism</subject><subject>Gentamicins - therapeutic use</subject><subject>Half-Life</subject><subject>Humans</subject><subject>Kidney - physiopathology</subject><subject>Kinetics</subject><subject>Medical sciences</subject><subject>Metabolic Clearance Rate</subject><subject>Models, Biological</subject><subject>Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions</subject><subject>Pharmacology. Drug treatments</subject><issn>0163-4356</issn><issn>1536-3694</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9UctOxCAUJUaj4-MTTFgYd1Uoj1J3xvhKTNzoumHgopgOrUAX_oGfLZ0Zhw05z5vcixCm5IqStrkm5TWypRVtFSeyoGqm2B5aUMFkxWTL99GCUMkqzoQ8QscpfRFCuSLkEB3KhpOG1Qv0-6R7V_XeAR4jWG-yHwL2AU8hZb3sAUcIusduCmvpBvuc8JR97_PP7MufEPUIhTHYxukDr4bg8xB9-MA62FkfIhS1lMx4jNpskBlC8rak5950ig6c7hOcbf8T9P5w_3b3VL28Pj7f3b5UplY8Vy01XNeuFWQpa15by2snlGs0o8pJanXTOEEEg6blxoriAVL24yQUZFpgJ-hy0zvG4XuClLuVTwb6XgcYptQpSkVJsGJUG6OJQ0oRXDdGv9Lxp6Okm4_Q_R-h2x1hTc3R8-2MabkCuwtut170i62uU9mEizoYn3Y2pRSXgrA_-xeR2g</recordid><startdate>19840101</startdate><enddate>19840101</enddate><creator>Chow, M S</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19840101</creationdate><title>Half-life prediction in unstable renal function: its utility in therapeutic drug monitoring and theoretical and practical considerations</title><author>Chow, M S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c284t-91c4a2f950b6242dd42f58f7a318f61da77f5053e794cd5624e0060f6ecd5c9e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Bacterial Infections - blood</topic><topic>Bacterial Infections - drug therapy</topic><topic>Biological and medical sciences</topic><topic>Creatinine - blood</topic><topic>General pharmacology</topic><topic>Gentamicins - blood</topic><topic>Gentamicins - metabolism</topic><topic>Gentamicins - therapeutic use</topic><topic>Half-Life</topic><topic>Humans</topic><topic>Kidney - physiopathology</topic><topic>Kinetics</topic><topic>Medical sciences</topic><topic>Metabolic Clearance Rate</topic><topic>Models, Biological</topic><topic>Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions</topic><topic>Pharmacology. Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chow, M S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Therapeutic drug monitoring</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chow, M S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Half-life prediction in unstable renal function: its utility in therapeutic drug monitoring and theoretical and practical considerations</atitle><jtitle>Therapeutic drug monitoring</jtitle><addtitle>Ther Drug Monit</addtitle><date>1984-01-01</date><risdate>1984</risdate><volume>6</volume><issue>2</issue><spage>148</spage><epage>152</epage><pages>148-152</pages><issn>0163-4356</issn><eissn>1536-3694</eissn><coden>TDMODV</coden><abstract>A simple equation is derived to describe the changes in drug elimination half-life (t1/2) in correspondence to the changes in renal function (as measured by creatinine clearance). This equation can be utilized to predict the t1/2 at any time following an initial period in patients with unstable renal function provided that the initial t1/2 and renal function corresponding to each period are known. The clinical application of this equation in predicting 21 serum gentamicin concentrations (SGC) was evaluated in patients with unstable renal function. Excellent correlation (coefficient of determination, r2 = 0.88) between the predicted and measured SGC was obtained.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>6740732</pmid><doi>10.1097/00007691-198406000-00003</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0163-4356 |
| ispartof | Therapeutic drug monitoring, 1984-01, Vol.6 (2), p.148-152 |
| issn | 0163-4356 1536-3694 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Bacterial Infections - blood Bacterial Infections - drug therapy Biological and medical sciences Creatinine - blood General pharmacology Gentamicins - blood Gentamicins - metabolism Gentamicins - therapeutic use Half-Life Humans Kidney - physiopathology Kinetics Medical sciences Metabolic Clearance Rate Models, Biological Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments |
| title | Half-life prediction in unstable renal function: its utility in therapeutic drug monitoring and theoretical and practical considerations |
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