Effect of ethanol on glucose and amino acid metabolism in brain
Ethanol administration in hamsters altered glucose metabolism in the brain, resulting in increased glucose content and decreased incorporation of labeled carbon from 14C-glucose into the amino acids derived via the citric acid cycle and into lactate. In general, amino acid content of the brain chang...
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| Veröffentlicht in: | Biochemical pharmacology 1971-10, Vol.20 (10), p.2805-2812 |
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| container_title | Biochemical pharmacology |
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| creator | Roach, Mary K. Reese, W.N. |
| description | Ethanol administration in hamsters altered glucose metabolism in the brain, resulting in increased glucose content and decreased incorporation of labeled carbon from
14C-glucose into the amino acids derived via the citric acid cycle and into lactate. In general, amino acid content of the brain changed little after ethanol, but there was a significant decrease in aspartate and an increase in glutamine. These changes in glucose and amino acid metabolism are enhanced by increasing ethanol doses. However, they seem to be an indirect effect of ethanol, since they do not appear until 20–30 min after ethanol injection, despite high blood ethanol levels throughout this period. |
| doi_str_mv | 10.1016/0006-2952(71)90191-2 |
| format | Article |
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14C-glucose into the amino acids derived via the citric acid cycle and into lactate. In general, amino acid content of the brain changed little after ethanol, but there was a significant decrease in aspartate and an increase in glutamine. These changes in glucose and amino acid metabolism are enhanced by increasing ethanol doses. However, they seem to be an indirect effect of ethanol, since they do not appear until 20–30 min after ethanol injection, despite high blood ethanol levels throughout this period.</description><identifier>ISSN: 0006-2952</identifier><identifier>EISSN: 1873-2968</identifier><identifier>DOI: 10.1016/0006-2952(71)90191-2</identifier><identifier>PMID: 5114514</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Alanine - metabolism ; Amino Acids - biosynthesis ; Amino Acids - metabolism ; Aminobutyrates - metabolism ; Animals ; Aspartic Acid - metabolism ; Blood Glucose - analysis ; Brain - metabolism ; Carbon Isotopes ; Chromatography, Ion Exchange ; Cricetinae ; Ethanol - administration & dosage ; Ethanol - blood ; Ethanol - pharmacology ; Glucose - metabolism ; Glutamates - metabolism ; Glutamine - metabolism ; Lactates - metabolism ; Male</subject><ispartof>Biochemical pharmacology, 1971-10, Vol.20 (10), p.2805-2812</ispartof><rights>1971</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-128a171df57db936759e7ba53bbdcd0e4b02ba85da805ee3eee968cfe61c1fc3</citedby><cites>FETCH-LOGICAL-c357t-128a171df57db936759e7ba53bbdcd0e4b02ba85da805ee3eee968cfe61c1fc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0006295271901912$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5114514$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Roach, Mary K.</creatorcontrib><creatorcontrib>Reese, W.N.</creatorcontrib><title>Effect of ethanol on glucose and amino acid metabolism in brain</title><title>Biochemical pharmacology</title><addtitle>Biochem Pharmacol</addtitle><description>Ethanol administration in hamsters altered glucose metabolism in the brain, resulting in increased glucose content and decreased incorporation of labeled carbon from
14C-glucose into the amino acids derived via the citric acid cycle and into lactate. In general, amino acid content of the brain changed little after ethanol, but there was a significant decrease in aspartate and an increase in glutamine. These changes in glucose and amino acid metabolism are enhanced by increasing ethanol doses. However, they seem to be an indirect effect of ethanol, since they do not appear until 20–30 min after ethanol injection, despite high blood ethanol levels throughout this period.</description><subject>Alanine - metabolism</subject><subject>Amino Acids - biosynthesis</subject><subject>Amino Acids - metabolism</subject><subject>Aminobutyrates - metabolism</subject><subject>Animals</subject><subject>Aspartic Acid - metabolism</subject><subject>Blood Glucose - analysis</subject><subject>Brain - metabolism</subject><subject>Carbon Isotopes</subject><subject>Chromatography, Ion Exchange</subject><subject>Cricetinae</subject><subject>Ethanol - administration & dosage</subject><subject>Ethanol - blood</subject><subject>Ethanol - pharmacology</subject><subject>Glucose - metabolism</subject><subject>Glutamates - metabolism</subject><subject>Glutamine - metabolism</subject><subject>Lactates - metabolism</subject><subject>Male</subject><issn>0006-2952</issn><issn>1873-2968</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1971</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMo67r6DxRyEj1UM23TtBdFlvUDFrzsPeRjqpE2WZtW8N_buotHT8PM-84M70PIObAbYFDcMsaKJK14eiXgumJQQZIekDmUIhvHRXlI5n-WY3IS48fUlgXMyIwD5BzyOblf1TWanoaaYv-ufGho8PStGUyISJW3VLXOB6qMs7TFXunQuNhS56nulPOn5KhWTcSzfV2QzeNqs3xO1q9PL8uHdWIyLvoE0lKBAFtzYXWVFYJXKLTimdbWWIa5ZqlWJbeqZBwxQ8QxgamxAAO1yRbkcnd224XPAWMvWxcNNo3yGIYoyzEPZHk6GvOd0XQhxg5rue1cq7pvCUxO2OQEQU5MpAD5i01Oaxf7-4Nu0f4t7TmN-t1OxzHjl8NORuPQG7SuG_FJG9z_D34AkHd7wQ</recordid><startdate>197110</startdate><enddate>197110</enddate><creator>Roach, Mary K.</creator><creator>Reese, W.N.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197110</creationdate><title>Effect of ethanol on glucose and amino acid metabolism in brain</title><author>Roach, Mary K. ; Reese, W.N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-128a171df57db936759e7ba53bbdcd0e4b02ba85da805ee3eee968cfe61c1fc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1971</creationdate><topic>Alanine - metabolism</topic><topic>Amino Acids - biosynthesis</topic><topic>Amino Acids - metabolism</topic><topic>Aminobutyrates - metabolism</topic><topic>Animals</topic><topic>Aspartic Acid - metabolism</topic><topic>Blood Glucose - analysis</topic><topic>Brain - metabolism</topic><topic>Carbon Isotopes</topic><topic>Chromatography, Ion Exchange</topic><topic>Cricetinae</topic><topic>Ethanol - administration & dosage</topic><topic>Ethanol - blood</topic><topic>Ethanol - pharmacology</topic><topic>Glucose - metabolism</topic><topic>Glutamates - metabolism</topic><topic>Glutamine - metabolism</topic><topic>Lactates - metabolism</topic><topic>Male</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Roach, Mary K.</creatorcontrib><creatorcontrib>Reese, W.N.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Roach, Mary K.</au><au>Reese, W.N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of ethanol on glucose and amino acid metabolism in brain</atitle><jtitle>Biochemical pharmacology</jtitle><addtitle>Biochem Pharmacol</addtitle><date>1971-10</date><risdate>1971</risdate><volume>20</volume><issue>10</issue><spage>2805</spage><epage>2812</epage><pages>2805-2812</pages><issn>0006-2952</issn><eissn>1873-2968</eissn><abstract>Ethanol administration in hamsters altered glucose metabolism in the brain, resulting in increased glucose content and decreased incorporation of labeled carbon from
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| ispartof | Biochemical pharmacology, 1971-10, Vol.20 (10), p.2805-2812 |
| issn | 0006-2952 1873-2968 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Alanine - metabolism Amino Acids - biosynthesis Amino Acids - metabolism Aminobutyrates - metabolism Animals Aspartic Acid - metabolism Blood Glucose - analysis Brain - metabolism Carbon Isotopes Chromatography, Ion Exchange Cricetinae Ethanol - administration & dosage Ethanol - blood Ethanol - pharmacology Glucose - metabolism Glutamates - metabolism Glutamine - metabolism Lactates - metabolism Male |
| title | Effect of ethanol on glucose and amino acid metabolism in brain |
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