Serum vitamin B12 concentration after proximal gastric vagotomy
The serum concentration of vitamin B12, blood hemoglobin, and gastric acid secretion capacity was studied preoperatively and 1 and 5 years after proximal gastric vagotomy (PGV) in 15 patients. There was a significant reduction in the mean concentration of vitamin B12 at 1 year, but this disappeared...
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| Veröffentlicht in: | Scandinavian journal of gastroenterology 1984-05, Vol.19 (3), p.445-448 |
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| container_end_page | 448 |
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| container_title | Scandinavian journal of gastroenterology |
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| creator | PAIMELA, H AHONEN, J HOCKERSTEDT, K SCHEININ, T. M |
| description | The serum concentration of vitamin B12, blood hemoglobin, and gastric acid secretion capacity was studied preoperatively and 1 and 5 years after proximal gastric vagotomy (PGV) in 15 patients. There was a significant reduction in the mean concentration of vitamin B12 at 1 year, but this disappeared within 5 years after PGV. The serum concentration of vitamin B12, however, remained at all times within the health-related reference interval. The blood hemoglobin concentration was unaltered during the follow-up period. The decrease in gastric acid secretion capacity gained by PGV was permanent, and no tendency to increased acidity was observed during the 5-year period. The temporary decrease in serum concentration of vitamin B12 reflects a PGV-induced diminished production of intrinsic factor in the parietal cells. In the characterization of parietal cell function the determination of serum vitamin B12 concentration is, however, much less sensitive than gastric acid secretion tests. The observed change in vitamin B12 concentration after PGV was subclinical, self-corrected, and thus required no treatment. |
| doi_str_mv | 10.1080/00365521.1984.12005750 |
| format | Article |
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M</creator><creatorcontrib>PAIMELA, H ; AHONEN, J ; HOCKERSTEDT, K ; SCHEININ, T. M</creatorcontrib><description>The serum concentration of vitamin B12, blood hemoglobin, and gastric acid secretion capacity was studied preoperatively and 1 and 5 years after proximal gastric vagotomy (PGV) in 15 patients. There was a significant reduction in the mean concentration of vitamin B12 at 1 year, but this disappeared within 5 years after PGV. The serum concentration of vitamin B12, however, remained at all times within the health-related reference interval. The blood hemoglobin concentration was unaltered during the follow-up period. The decrease in gastric acid secretion capacity gained by PGV was permanent, and no tendency to increased acidity was observed during the 5-year period. The temporary decrease in serum concentration of vitamin B12 reflects a PGV-induced diminished production of intrinsic factor in the parietal cells. In the characterization of parietal cell function the determination of serum vitamin B12 concentration is, however, much less sensitive than gastric acid secretion tests. The observed change in vitamin B12 concentration after PGV was subclinical, self-corrected, and thus required no treatment.</description><identifier>ISSN: 0036-5521</identifier><identifier>EISSN: 1502-7708</identifier><identifier>DOI: 10.1080/00365521.1984.12005750</identifier><identifier>PMID: 6740222</identifier><identifier>CODEN: SJGRA4</identifier><language>eng</language><publisher>Copenhagen: Scandinavian University Press</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Female ; Gastric Acid - secretion ; Hemoglobins - analysis ; Humans ; Male ; Medical sciences ; Middle Aged ; Stomach, duodenum, intestine, rectum, anus ; Surgery (general aspects). Transplantations, organ and tissue grafts. 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M</creatorcontrib><title>Serum vitamin B12 concentration after proximal gastric vagotomy</title><title>Scandinavian journal of gastroenterology</title><addtitle>Scand J Gastroenterol</addtitle><description>The serum concentration of vitamin B12, blood hemoglobin, and gastric acid secretion capacity was studied preoperatively and 1 and 5 years after proximal gastric vagotomy (PGV) in 15 patients. There was a significant reduction in the mean concentration of vitamin B12 at 1 year, but this disappeared within 5 years after PGV. The serum concentration of vitamin B12, however, remained at all times within the health-related reference interval. The blood hemoglobin concentration was unaltered during the follow-up period. The decrease in gastric acid secretion capacity gained by PGV was permanent, and no tendency to increased acidity was observed during the 5-year period. The temporary decrease in serum concentration of vitamin B12 reflects a PGV-induced diminished production of intrinsic factor in the parietal cells. In the characterization of parietal cell function the determination of serum vitamin B12 concentration is, however, much less sensitive than gastric acid secretion tests. The observed change in vitamin B12 concentration after PGV was subclinical, self-corrected, and thus required no treatment.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Gastric Acid - secretion</subject><subject>Hemoglobins - analysis</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Stomach, duodenum, intestine, rectum, anus</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the digestive system</subject><subject>Vagotomy - adverse effects</subject><subject>Vagotomy, Proximal Gastric - adverse effects</subject><subject>Vitamin B 12 - blood</subject><subject>Vitamin B 12 Deficiency - etiology</subject><issn>0036-5521</issn><issn>1502-7708</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9z0tLxDAUBeAgyjiO_gSlC3HXepM0TbISHXzBgAt1Xe4k6VDpY0zSwfn3drC4uovzcTiXkCsKGQUFtwC8EILRjGqVZ5QBCCngiMypAJZKCeqYzA8oPahTchbCFxxQrmdkVsgcGGNzcvfu_NAmuzpiW3fJA2WJ6Tvjuugx1n2XYBWdT7a-_6lbbJINhuhrk-xw08e-3Z-Tkwqb4C6muyCfT48fy5d09fb8urxfpVvGRUwlWtSysqg0Z9KyqrLMIl-DKDQHKGzugFcF5Vwqu-ZOgeNUKkO1VUWBii_IzV_vuOR7cCGWbR2MaxrsXD-EUlGag9JshJcTHNats-XWj7v9vpw-HvPrKcdgsKk8dqYO_0xLpqnm_Bdh-mUf</recordid><startdate>198405</startdate><enddate>198405</enddate><creator>PAIMELA, H</creator><creator>AHONEN, J</creator><creator>HOCKERSTEDT, K</creator><creator>SCHEININ, T. M</creator><general>Scandinavian University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>198405</creationdate><title>Serum vitamin B12 concentration after proximal gastric vagotomy</title><author>PAIMELA, H ; AHONEN, J ; HOCKERSTEDT, K ; SCHEININ, T. M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p235t-7ada97fda89327d2ffd2da3b05693006d4e03f613378db3e80e3178c19d866a83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Gastric Acid - secretion</topic><topic>Hemoglobins - analysis</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Stomach, duodenum, intestine, rectum, anus</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the digestive system</topic><topic>Vagotomy - adverse effects</topic><topic>Vagotomy, Proximal Gastric - adverse effects</topic><topic>Vitamin B 12 - blood</topic><topic>Vitamin B 12 Deficiency - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PAIMELA, H</creatorcontrib><creatorcontrib>AHONEN, J</creatorcontrib><creatorcontrib>HOCKERSTEDT, K</creatorcontrib><creatorcontrib>SCHEININ, T. 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M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum vitamin B12 concentration after proximal gastric vagotomy</atitle><jtitle>Scandinavian journal of gastroenterology</jtitle><addtitle>Scand J Gastroenterol</addtitle><date>1984-05</date><risdate>1984</risdate><volume>19</volume><issue>3</issue><spage>445</spage><epage>448</epage><pages>445-448</pages><issn>0036-5521</issn><eissn>1502-7708</eissn><coden>SJGRA4</coden><abstract>The serum concentration of vitamin B12, blood hemoglobin, and gastric acid secretion capacity was studied preoperatively and 1 and 5 years after proximal gastric vagotomy (PGV) in 15 patients. There was a significant reduction in the mean concentration of vitamin B12 at 1 year, but this disappeared within 5 years after PGV. The serum concentration of vitamin B12, however, remained at all times within the health-related reference interval. The blood hemoglobin concentration was unaltered during the follow-up period. The decrease in gastric acid secretion capacity gained by PGV was permanent, and no tendency to increased acidity was observed during the 5-year period. The temporary decrease in serum concentration of vitamin B12 reflects a PGV-induced diminished production of intrinsic factor in the parietal cells. In the characterization of parietal cell function the determination of serum vitamin B12 concentration is, however, much less sensitive than gastric acid secretion tests. The observed change in vitamin B12 concentration after PGV was subclinical, self-corrected, and thus required no treatment.</abstract><cop>Copenhagen</cop><cop>Oslo</cop><cop>Stockholm</cop><pub>Scandinavian University Press</pub><pmid>6740222</pmid><doi>10.1080/00365521.1984.12005750</doi><tpages>4</tpages></addata></record> |
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| ispartof | Scandinavian journal of gastroenterology, 1984-05, Vol.19 (3), p.445-448 |
| issn | 0036-5521 1502-7708 |
| language | eng |
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| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Access via Taylor & Francis |
| subjects | Adult Aged Biological and medical sciences Female Gastric Acid - secretion Hemoglobins - analysis Humans Male Medical sciences Middle Aged Stomach, duodenum, intestine, rectum, anus Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the digestive system Vagotomy - adverse effects Vagotomy, Proximal Gastric - adverse effects Vitamin B 12 - blood Vitamin B 12 Deficiency - etiology |
| title | Serum vitamin B12 concentration after proximal gastric vagotomy |
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