Effects of phosphatidylserine on avoidance relearning in rats (preliminary observations)
During six learning sessions in a shuttle-box avoidance situation, male Sprague-Dawley rats show two kinds of learning efficiency which allow for dividing them in the subgroups of high-responding (HR) and low-responding (LR) animals. The effect of phosphatidylserine, a pharmacologically active phosp...
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| Veröffentlicht in: | Pharmacological research communications 1984-05, Vol.16 (5), p.485-493 |
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| container_title | Pharmacological research communications |
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| creator | Zanotti, Adriano Aporti, Ferrante Toffano, Gino Valzelli, Luigi |
| description | During six learning sessions in a shuttle-box avoidance situation, male Sprague-Dawley rats show two kinds of learning efficiency which allow for dividing them in the subgroups of high-responding (HR) and low-responding (LR) animals. The effect of phosphatidylserine, a pharmacologically active phospholipid obtained from bovine brain, has been studied on the relearning phase of these two populations of rats. Chronic administration of phosphatidylserine (15 mg/kg i.p. for 30 days) significantly increased the avoidance performances of LR animals, without changing those of HR rats. The results obtained suggest that the different behavioral response to the phosphatidylserine treatment may depend on the pre-drug baseline of avoidance learning capability and on the effect that the drug exerts on some brain neurotransmitter metabolism. |
| doi_str_mv | 10.1016/S0031-6989(84)80017-X |
| format | Article |
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The effect of phosphatidylserine, a pharmacologically active phospholipid obtained from bovine brain, has been studied on the relearning phase of these two populations of rats. Chronic administration of phosphatidylserine (15 mg/kg i.p. for 30 days) significantly increased the avoidance performances of LR animals, without changing those of HR rats. The results obtained suggest that the different behavioral response to the phosphatidylserine treatment may depend on the pre-drug baseline of avoidance learning capability and on the effect that the drug exerts on some brain neurotransmitter metabolism.</description><identifier>ISSN: 0031-6989</identifier><identifier>EISSN: 1879-2936</identifier><identifier>DOI: 10.1016/S0031-6989(84)80017-X</identifier><identifier>PMID: 6739523</identifier><language>eng</language><publisher>Orlando, FL: Elsevier B.V</publisher><subject>Animals ; Avoidance Learning - drug effects ; Behavior, Animal - drug effects ; Biological and medical sciences ; Conditioning, Classical - drug effects ; Escape Reaction - drug effects ; Liposomes - administration & dosage ; Male ; Medical sciences ; Miscellaneous ; Neuropharmacology ; Neurotransmitters. Neurotransmission. Receptors ; Pharmacology. 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The effect of phosphatidylserine, a pharmacologically active phospholipid obtained from bovine brain, has been studied on the relearning phase of these two populations of rats. Chronic administration of phosphatidylserine (15 mg/kg i.p. for 30 days) significantly increased the avoidance performances of LR animals, without changing those of HR rats. The results obtained suggest that the different behavioral response to the phosphatidylserine treatment may depend on the pre-drug baseline of avoidance learning capability and on the effect that the drug exerts on some brain neurotransmitter metabolism.</description><subject>Animals</subject><subject>Avoidance Learning - drug effects</subject><subject>Behavior, Animal - drug effects</subject><subject>Biological and medical sciences</subject><subject>Conditioning, Classical - drug effects</subject><subject>Escape Reaction - drug effects</subject><subject>Liposomes - administration & dosage</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Neuropharmacology</subject><subject>Neurotransmitters. Neurotransmission. Receptors</subject><subject>Pharmacology. Drug treatments</subject><subject>Phosphatidylserines - pharmacology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><issn>0031-6989</issn><issn>1879-2936</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctqAyEUhqW0pGnaRwjMopRkMa2Oo6OrUkJ6gUAXbSE7cdRpLBOdahLI29dcyLYr0fP95xw-ARgieI8gog8fEGKUU874iJVjBiGq8vkZ6CNW8bzgmJ6D_gm5BFcx_qRrQRHsgR6tMCcF7oP5tGmMWsXMN1m38LFbyJXV2zaaYJ3JvMvkxlstnTJZMK2RwVn3nVmXBZlSoy492qV1MmwzX6fUJuW9i-NrcNHI1ObmeA7A1_P0c_Kaz95f3iZPs1yVhKxyJlVdIk55TTVkpmggrqBRpCRSc66RkpgjTBTjkpQFk2VTV5UiBGGoNFEUD8DdoW8X_O_axJVY2qhM20pn_DoKhhCmFFcJJAdQBR9jMI3ogl2mvQWCYmdU7I2KnS7BSrE3KuYpNzwOWNdLo0-po8JUvz3WZVSybUJyZeMJY7ziJSwS9njATJKxsSaIqKxJWrUN6QOE9vafRf4AtdmTtg</recordid><startdate>198405</startdate><enddate>198405</enddate><creator>Zanotti, Adriano</creator><creator>Aporti, Ferrante</creator><creator>Toffano, Gino</creator><creator>Valzelli, Luigi</creator><general>Elsevier B.V</general><general>Academic Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198405</creationdate><title>Effects of phosphatidylserine on avoidance relearning in rats (preliminary observations)</title><author>Zanotti, Adriano ; Aporti, Ferrante ; Toffano, Gino ; Valzelli, Luigi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-8acb41969b6d08e2f0370ec545ad99d1ca39135c89a5428a4fb77c55130cd5c63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Animals</topic><topic>Avoidance Learning - drug effects</topic><topic>Behavior, Animal - drug effects</topic><topic>Biological and medical sciences</topic><topic>Conditioning, Classical - drug effects</topic><topic>Escape Reaction - drug effects</topic><topic>Liposomes - administration & dosage</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>Neuropharmacology</topic><topic>Neurotransmitters. Neurotransmission. Receptors</topic><topic>Pharmacology. Drug treatments</topic><topic>Phosphatidylserines - pharmacology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><toplevel>online_resources</toplevel><creatorcontrib>Zanotti, Adriano</creatorcontrib><creatorcontrib>Aporti, Ferrante</creatorcontrib><creatorcontrib>Toffano, Gino</creatorcontrib><creatorcontrib>Valzelli, Luigi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacological research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zanotti, Adriano</au><au>Aporti, Ferrante</au><au>Toffano, Gino</au><au>Valzelli, Luigi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of phosphatidylserine on avoidance relearning in rats (preliminary observations)</atitle><jtitle>Pharmacological research communications</jtitle><addtitle>Pharmacol Res Commun</addtitle><date>1984-05</date><risdate>1984</risdate><volume>16</volume><issue>5</issue><spage>485</spage><epage>493</epage><pages>485-493</pages><issn>0031-6989</issn><eissn>1879-2936</eissn><abstract>During six learning sessions in a shuttle-box avoidance situation, male Sprague-Dawley rats show two kinds of learning efficiency which allow for dividing them in the subgroups of high-responding (HR) and low-responding (LR) animals. The effect of phosphatidylserine, a pharmacologically active phospholipid obtained from bovine brain, has been studied on the relearning phase of these two populations of rats. Chronic administration of phosphatidylserine (15 mg/kg i.p. for 30 days) significantly increased the avoidance performances of LR animals, without changing those of HR rats. The results obtained suggest that the different behavioral response to the phosphatidylserine treatment may depend on the pre-drug baseline of avoidance learning capability and on the effect that the drug exerts on some brain neurotransmitter metabolism.</abstract><cop>Orlando, FL</cop><cop>London</cop><pub>Elsevier B.V</pub><pmid>6739523</pmid><doi>10.1016/S0031-6989(84)80017-X</doi><tpages>9</tpages></addata></record> |
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| ispartof | Pharmacological research communications, 1984-05, Vol.16 (5), p.485-493 |
| issn | 0031-6989 1879-2936 |
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| subjects | Animals Avoidance Learning - drug effects Behavior, Animal - drug effects Biological and medical sciences Conditioning, Classical - drug effects Escape Reaction - drug effects Liposomes - administration & dosage Male Medical sciences Miscellaneous Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments Phosphatidylserines - pharmacology Rats Rats, Inbred Strains |
| title | Effects of phosphatidylserine on avoidance relearning in rats (preliminary observations) |
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