Troponoids. 6. Troponylpiperazines: a new class of dopamine agonists

A series of alkyltroponylpiperazine derivatives was synthesized and evaluated for dopaminergic activity in rats rendered hypokinetic by the bilateral injection of 6-hydroxydopamine (6-OHDA) into the anterolateral hypothalamus. Several members of the series were active, and a structure-activity relat...

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Veröffentlicht in:	Journal of medicinal chemistry 1984-07, Vol.27 (7), p.875-881
Hauptverfasser:	Bagli, Jehan, Bogri, T, Voith, Katherine
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bromocriptine - pharmacology Cycloheptanes - chemical synthesis Disease Models, Animal Hydroxydopamines - pharmacology Male Oxidopamine Parkinson Disease - drug therapy Piperazines - chemical synthesis Piperazines - pharmacology Rats Rats, Inbred Strains Receptors, Dopamine - metabolism Structure-Activity Relationship Tropolone - analogs & derivatives Tropolone - chemical synthesis Tropolone - pharmacology
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