A microchemical facility for the analysis and synthesis of genes and proteins
A series of automated instruments that use state-of-the-art chemical methods has been developed for high-sensitivity protein sequencing, DNA synthesis and peptide synthesis. These intruments have been integrated into a centralized microchemical facility in order to promote their use for the study of...
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| Veröffentlicht in: | Nature (London) 1984-07, Vol.310 (5973), p.105-111 |
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| container_end_page | 111 |
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| container_issue | 5973 |
| container_start_page | 105 |
| container_title | Nature (London) |
| container_volume | 310 |
| creator | Hunkapiller, M. Kent, S. Caruthers, M. Dreyer, W. Firca, J. Giffin, C. Horvath, S. Hunkapiller, T. Tempst, P. Hood, L. |
| description | A series of automated instruments that use state-of-the-art chemical methods has been developed for high-sensitivity protein sequencing, DNA synthesis and peptide synthesis. These intruments have been integrated into a centralized microchemical facility in order to promote their use for the study of a variety of biologically interesting problems. This facility has as one of its major functions the development of new chemistries and instrumentation for the structural analysis and synthesis of genes and proteins. |
| doi_str_mv | 10.1038/310105a0 |
| format | Article |
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These intruments have been integrated into a centralized microchemical facility in order to promote their use for the study of a variety of biologically interesting problems. This facility has as one of its major functions the development of new chemistries and instrumentation for the structural analysis and synthesis of genes and proteins.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/310105a0</identifier><identifier>PMID: 6738709</identifier><identifier>CODEN: NATUAS</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Amino Acid Sequence ; Antibodies ; Autoanalysis ; Base Sequence ; Biological and medical sciences ; Biotechnology ; Chromatography, High Pressure Liquid - methods ; Computers ; Diverse techniques ; Fundamental and applied biological sciences. Psychology ; Genes ; Genes, Synthetic ; Genetic engineering ; Genetic technics ; Humanities and Social Sciences ; Indicators and Reagents ; Mass Spectrometry - instrumentation ; Mass Spectrometry - methods ; Methods. Procedures. Technologies ; Molecular and cellular biology ; multidisciplinary ; Oligodeoxyribonucleotides - chemical synthesis ; Phenylthiohydantoin ; Proteins - chemical synthesis ; review-article ; Science ; Science (multidisciplinary) ; Synthetic digonucleotides and genes. 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Psychology</subject><subject>Genes</subject><subject>Genes, Synthetic</subject><subject>Genetic engineering</subject><subject>Genetic technics</subject><subject>Humanities and Social Sciences</subject><subject>Indicators and Reagents</subject><subject>Mass Spectrometry - instrumentation</subject><subject>Mass Spectrometry - methods</subject><subject>Methods. Procedures. Technologies</subject><subject>Molecular and cellular biology</subject><subject>multidisciplinary</subject><subject>Oligodeoxyribonucleotides - chemical synthesis</subject><subject>Phenylthiohydantoin</subject><subject>Proteins - chemical synthesis</subject><subject>review-article</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Synthetic digonucleotides and genes. 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| fulltext | fulltext |
| identifier | ISSN: 0028-0836 |
| ispartof | Nature (London), 1984-07, Vol.310 (5973), p.105-111 |
| issn | 0028-0836 1476-4687 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_81131864 |
| source | MEDLINE; SpringerLink Journals; Nature Journals Online |
| subjects | Amino Acid Sequence Antibodies Autoanalysis Base Sequence Biological and medical sciences Biotechnology Chromatography, High Pressure Liquid - methods Computers Diverse techniques Fundamental and applied biological sciences. Psychology Genes Genes, Synthetic Genetic engineering Genetic technics Humanities and Social Sciences Indicators and Reagents Mass Spectrometry - instrumentation Mass Spectrometry - methods Methods. Procedures. Technologies Molecular and cellular biology multidisciplinary Oligodeoxyribonucleotides - chemical synthesis Phenylthiohydantoin Proteins - chemical synthesis review-article Science Science (multidisciplinary) Synthetic digonucleotides and genes. Sequencing |
| title | A microchemical facility for the analysis and synthesis of genes and proteins |
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