Modification of the haemoglobin oxygen dissociation curve in whole blood by a compound with dual action

2-Ethoxy-6-(5-tetrazolyl)xanthone reduces the oxygen affinity of blood by two mechanisms; firstly, by a direct effect on the haemoglobin molecule and secondly by maintaining levels of 2,3-diphosphoglycerate (DPG) in stored blood. This compound thus has potential as a blood storage additive which wil...

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Veröffentlicht in:	The Lancet (British edition) 1984-07, Vol.2 (8393), p.15-16
Hauptverfasser:	Hyde, R M, Livingstone, D J, Patterson, R A, Batchelor, J F, King, W R
Format:	Artikel
Sprache:	eng
Schlagworte:	2,3-Diphosphoglycerate Adenosine Triphosphate - blood Blood Preservation Diphosphoglyceric Acids - blood Erythrocytes - drug effects Erythrocytes - metabolism Hemoglobins - metabolism Humans Hydrogen-Ion Concentration Oxygen - blood Xanthenes - pharmacology Xanthones
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Beschreibung
Zusammenfassung:	2-Ethoxy-6-(5-tetrazolyl)xanthone reduces the oxygen affinity of blood by two mechanisms; firstly, by a direct effect on the haemoglobin molecule and secondly by maintaining levels of 2,3-diphosphoglycerate (DPG) in stored blood. This compound thus has potential as a blood storage additive which will improve the oxygen delivery of stored blood.
ISSN:	0140-6736