Clinical relevance of thiothixene plasma levels
The authors examined plasma levels of thiothixene and clinical response in 19 DSM-III diagnosed inpatient schizophrenics, using an improved methodology. A significant curvilinear correlation was demonstrated between clinical response and plasma levels for thiothixene (p less than 0.02). Optimal clin...
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| Veröffentlicht in: | Journal of clinical psychopharmacology 1984-06, Vol.4 (3), p.155-157 |
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| container_end_page | 157 |
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| container_issue | 3 |
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| container_title | Journal of clinical psychopharmacology |
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| creator | MAVROIDIS, M. L KANTER, D. R HIRSCHOWITZ, J GARVER, D. L |
| description | The authors examined plasma levels of thiothixene and clinical response in 19 DSM-III diagnosed inpatient schizophrenics, using an improved methodology. A significant curvilinear correlation was demonstrated between clinical response and plasma levels for thiothixene (p less than 0.02). Optimal clinical response to thiothixene appears to be associated with plasma levels from 2.0 to 15.0 ng/ml (p less than 0.05). These findings suggest that laboratory measurement of thiothixene levels may assist in determining the minimum effective dose for individual patients. |
| doi_str_mv | 10.1097/00004714-198406000-00011 |
| format | Article |
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These findings suggest that laboratory measurement of thiothixene levels may assist in determining the minimum effective dose for individual patients.</description><identifier>ISSN: 0271-0749</identifier><identifier>EISSN: 1533-712X</identifier><identifier>DOI: 10.1097/00004714-198406000-00011</identifier><identifier>PMID: 6736276</identifier><identifier>CODEN: JCPYDR</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Biological and medical sciences ; Humans ; Medical sciences ; Neuropharmacology ; Pharmacology. Drug treatments ; Psychiatric Status Rating Scales ; Psycholeptics: tranquillizer, neuroleptic ; Psychology. Psychoanalysis. 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These findings suggest that laboratory measurement of thiothixene levels may assist in determining the minimum effective dose for individual patients.</description><subject>Biological and medical sciences</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psycholeptics: tranquillizer, neuroleptic</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Schizophrenia - drug therapy</subject><subject>Thiothixene - blood</subject><subject>Thiothixene - therapeutic use</subject><subject>Time Factors</subject><issn>0271-0749</issn><issn>1533-712X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE9LxDAQxYMo67r6EYQexFvcTJMm6VEW_8GCFwVvIU0nWEnbNdkV_fZGrTswDMl7bxJ-hBTAroDVaslyCQWCQq0Fk_lEcwMckDlUnFMF5cshmbNSAWVK1MfkJKW37BCqrGZkJhWXpZJzslyFbuicDUXEgB92cFiMvti-dmPuTxyw2ASbeltkFUM6JUfehoRn01yQ59ubp9U9XT_ePayu19RxXm-pQK9QV6V0jXYAzIOtWsaF95Z7LaWwMn-La1mDBeubfNe22DDtrMa2cnxBLv_2buL4vsO0NX2XHIZgBxx3yWiAUldcZaP-M7o4phTRm03sehu_DDDzw8r8szJ7VuaXVY6eT2_smh7bfXCCk_WLSbcpE_Ix0-nS3lYzWUul-Tfzt3DU</recordid><startdate>198406</startdate><enddate>198406</enddate><creator>MAVROIDIS, M. L</creator><creator>KANTER, D. R</creator><creator>HIRSCHOWITZ, J</creator><creator>GARVER, D. 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Drug treatments</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psycholeptics: tranquillizer, neuroleptic</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Schizophrenia - drug therapy</topic><topic>Thiothixene - blood</topic><topic>Thiothixene - therapeutic use</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MAVROIDIS, M. L</creatorcontrib><creatorcontrib>KANTER, D. R</creatorcontrib><creatorcontrib>HIRSCHOWITZ, J</creatorcontrib><creatorcontrib>GARVER, D. 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L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical relevance of thiothixene plasma levels</atitle><jtitle>Journal of clinical psychopharmacology</jtitle><addtitle>J Clin Psychopharmacol</addtitle><date>1984-06</date><risdate>1984</risdate><volume>4</volume><issue>3</issue><spage>155</spage><epage>157</epage><pages>155-157</pages><issn>0271-0749</issn><eissn>1533-712X</eissn><coden>JCPYDR</coden><abstract>The authors examined plasma levels of thiothixene and clinical response in 19 DSM-III diagnosed inpatient schizophrenics, using an improved methodology. A significant curvilinear correlation was demonstrated between clinical response and plasma levels for thiothixene (p less than 0.02). Optimal clinical response to thiothixene appears to be associated with plasma levels from 2.0 to 15.0 ng/ml (p less than 0.05). 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| identifier | ISSN: 0271-0749 |
| ispartof | Journal of clinical psychopharmacology, 1984-06, Vol.4 (3), p.155-157 |
| issn | 0271-0749 1533-712X |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Biological and medical sciences Humans Medical sciences Neuropharmacology Pharmacology. Drug treatments Psychiatric Status Rating Scales Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Schizophrenia - drug therapy Thiothixene - blood Thiothixene - therapeutic use Time Factors |
| title | Clinical relevance of thiothixene plasma levels |
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