Intestinal uptake of bile acids: Effect of external abdominal irradiation
Abdominal irradiation has recently been shown to influence the uptake of hexoses, amino acids, fatty acids and cholesterol into the jejunum of rats. The present studies were undertaken with a previously validated in vitro technique to determine the effect of abdominal irradiation from a cesium 137 s...
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| Veröffentlicht in: | Int. J. Radiat. Oncol., Biol. Phys.; (United States) Biol. Phys.; (United States), 1984-01, Vol.10 (5), p.671-685 |
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| creator | Thomson, A.B.R. Cheeseman, C.I. Walker, K. |
| description | Abdominal irradiation has recently been shown to influence the uptake of hexoses, amino acids, fatty acids and cholesterol into the jejunum of rats. The present studies were undertaken with a previously validated
in vitro technique to determine the effect of abdominal irradiation from a cesium
137 source on the rates of uptake of six bile acids into the jejunum, ileum, and colon. In the ileum of control rats, there were marked differences in the value of the apparent Michaelis constant (Km
∗), maximal transport rate (J
d
m), and apparent passive permeability coefficient (Pd
∗) between cholic (C), glycocholic (GC), taurocholic (TC), chenodeoxycholic (CDC), and glycochenodeoxycholic (GCDC), and deoxycholic (DC) acid. The Km
∗ for each bile acid except. DC was lower three and 14 days after 600 rad, whereas the J
d
m for GC fell, but rose for TC, CDC, GCDC and DC and was unchanged for C. The Pd
∗ rose for C, GC, and DC, fell for TC and CDC, but remained unchanged for GCDC 14 days after irradiation. After 600 rad the value of Pd
∗ in the colon was increased at day 3 and 14 for CDC and GCDC, but was unchanged for GC and TC and was decreased for C. The uptake of bile acids was also affected by 300 rad and by 900 rad, but the direction and magnitude of the change was influenced by the intestinal site, the dose of irradiation, and the type of bile acid. The results show that: 1) there likely are multiple ileal carriers for bile acids; 2) abdominal irradiation has a variable effect on these carriers; 3) the passive permeability to bile acids varies with the bile acid and with the site along the intestine; and 4) abdominal irradiation is associated with a rise in the colonic permeability to only some bile acids. |
| doi_str_mv | 10.1016/0360-3016(84)90299-2 |
| format | Article |
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in vitro technique to determine the effect of abdominal irradiation from a cesium
137 source on the rates of uptake of six bile acids into the jejunum, ileum, and colon. In the ileum of control rats, there were marked differences in the value of the apparent Michaelis constant (Km
∗), maximal transport rate (J
d
m), and apparent passive permeability coefficient (Pd
∗) between cholic (C), glycocholic (GC), taurocholic (TC), chenodeoxycholic (CDC), and glycochenodeoxycholic (GCDC), and deoxycholic (DC) acid. The Km
∗ for each bile acid except. DC was lower three and 14 days after 600 rad, whereas the J
d
m for GC fell, but rose for TC, CDC, GCDC and DC and was unchanged for C. The Pd
∗ rose for C, GC, and DC, fell for TC and CDC, but remained unchanged for GCDC 14 days after irradiation. After 600 rad the value of Pd
∗ in the colon was increased at day 3 and 14 for CDC and GCDC, but was unchanged for GC and TC and was decreased for C. The uptake of bile acids was also affected by 300 rad and by 900 rad, but the direction and magnitude of the change was influenced by the intestinal site, the dose of irradiation, and the type of bile acid. The results show that: 1) there likely are multiple ileal carriers for bile acids; 2) abdominal irradiation has a variable effect on these carriers; 3) the passive permeability to bile acids varies with the bile acid and with the site along the intestine; and 4) abdominal irradiation is associated with a rise in the colonic permeability to only some bile acids.</description><identifier>ISSN: 0360-3016</identifier><identifier>EISSN: 1879-355X</identifier><identifier>DOI: 10.1016/0360-3016(84)90299-2</identifier><identifier>PMID: 6735756</identifier><identifier>CODEN: IOBPD3</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>ABDOMEN ; Abdomen - radiation effects ; ABSORPTION ; ALKALI METAL ISOTOPES ; ANIMALS ; BETA DECAY RADIOISOTOPES ; BETA-MINUS DECAY RADIOISOTOPES ; BILE ACIDS ; Bile Acids and Salts - metabolism ; BIOCHEMICAL REACTION KINETICS ; Biological and medical sciences ; BIOLOGICAL EFFECTS ; Biological effects of radiation ; BIOLOGICAL RADIATION EFFECTS ; BODY ; BODY AREAS ; CARBOXYLIC ACIDS ; CESIUM 137 ; CESIUM ISOTOPES ; Cesium Radioisotopes ; Chenodeoxycholic Acid - metabolism ; Cholic Acid ; Cholic Acids - metabolism ; Colon - radiation effects ; DATA ; ELECTROMAGNETIC RADIATION ; EXPERIMENTAL DATA ; Female ; Fundamental and applied biological sciences. Psychology ; GAMMA RADIATION ; Glycochenodeoxycholic Acid - metabolism ; Glycocholic Acid - metabolism ; HYDROXY COMPOUNDS ; Ileum - radiation effects ; INFORMATION ; INTESTINAL ABSORPTION ; Intestinal Absorption - radiation effects ; IONIZING RADIATIONS ; ISOTOPES ; Jejunum - radiation effects ; KINETICS ; MAMMALS ; NUCLEI ; NUMERICAL DATA ; ODD-EVEN NUCLEI ; ORGANIC ACIDS ; ORGANIC COMPOUNDS ; PERMEABILITY ; RADIATION EFFECTS ; RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT ; RADIATIONS ; RADIOISOTOPES ; RATS ; Rats, Inbred Strains ; REACTION KINETICS ; RODENTS ; STEROIDS ; STEROLS ; Taurocholic Acid - metabolism ; Tissues, organs and organisms biophysics ; Unstirred water layer ; UPTAKE ; VERTEBRATES ; YEARS LIVING RADIOISOTOPES 560152 -- Radiation Effects on Animals-- Animals</subject><ispartof>Int. J. Radiat. Oncol., Biol. Phys.; (United States), 1984-01, Vol.10 (5), p.671-685</ispartof><rights>1984</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c444t-2b7028dabddb5f6eebaffe80615a90e55a9658a78e7b941b7920353cd492d3af3</citedby><cites>FETCH-LOGICAL-c444t-2b7028dabddb5f6eebaffe80615a90e55a9658a78e7b941b7920353cd492d3af3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0360301684902992$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8876941$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6735756$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/6667280$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Thomson, A.B.R.</creatorcontrib><creatorcontrib>Cheeseman, C.I.</creatorcontrib><creatorcontrib>Walker, K.</creatorcontrib><creatorcontrib>Univ. of Alberta, Edmonton</creatorcontrib><title>Intestinal uptake of bile acids: Effect of external abdominal irradiation</title><title>Int. J. Radiat. Oncol., Biol. Phys.; (United States)</title><addtitle>Int J Radiat Oncol Biol Phys</addtitle><description>Abdominal irradiation has recently been shown to influence the uptake of hexoses, amino acids, fatty acids and cholesterol into the jejunum of rats. The present studies were undertaken with a previously validated
in vitro technique to determine the effect of abdominal irradiation from a cesium
137 source on the rates of uptake of six bile acids into the jejunum, ileum, and colon. In the ileum of control rats, there were marked differences in the value of the apparent Michaelis constant (Km
∗), maximal transport rate (J
d
m), and apparent passive permeability coefficient (Pd
∗) between cholic (C), glycocholic (GC), taurocholic (TC), chenodeoxycholic (CDC), and glycochenodeoxycholic (GCDC), and deoxycholic (DC) acid. The Km
∗ for each bile acid except. DC was lower three and 14 days after 600 rad, whereas the J
d
m for GC fell, but rose for TC, CDC, GCDC and DC and was unchanged for C. The Pd
∗ rose for C, GC, and DC, fell for TC and CDC, but remained unchanged for GCDC 14 days after irradiation. After 600 rad the value of Pd
∗ in the colon was increased at day 3 and 14 for CDC and GCDC, but was unchanged for GC and TC and was decreased for C. The uptake of bile acids was also affected by 300 rad and by 900 rad, but the direction and magnitude of the change was influenced by the intestinal site, the dose of irradiation, and the type of bile acid. The results show that: 1) there likely are multiple ileal carriers for bile acids; 2) abdominal irradiation has a variable effect on these carriers; 3) the passive permeability to bile acids varies with the bile acid and with the site along the intestine; and 4) abdominal irradiation is associated with a rise in the colonic permeability to only some bile acids.</description><subject>ABDOMEN</subject><subject>Abdomen - radiation effects</subject><subject>ABSORPTION</subject><subject>ALKALI METAL ISOTOPES</subject><subject>ANIMALS</subject><subject>BETA DECAY RADIOISOTOPES</subject><subject>BETA-MINUS DECAY RADIOISOTOPES</subject><subject>BILE ACIDS</subject><subject>Bile Acids and Salts - metabolism</subject><subject>BIOCHEMICAL REACTION KINETICS</subject><subject>Biological and medical sciences</subject><subject>BIOLOGICAL EFFECTS</subject><subject>Biological effects of radiation</subject><subject>BIOLOGICAL RADIATION EFFECTS</subject><subject>BODY</subject><subject>BODY AREAS</subject><subject>CARBOXYLIC ACIDS</subject><subject>CESIUM 137</subject><subject>CESIUM ISOTOPES</subject><subject>Cesium Radioisotopes</subject><subject>Chenodeoxycholic Acid - metabolism</subject><subject>Cholic Acid</subject><subject>Cholic Acids - metabolism</subject><subject>Colon - radiation effects</subject><subject>DATA</subject><subject>ELECTROMAGNETIC RADIATION</subject><subject>EXPERIMENTAL DATA</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GAMMA RADIATION</subject><subject>Glycochenodeoxycholic Acid - metabolism</subject><subject>Glycocholic Acid - metabolism</subject><subject>HYDROXY COMPOUNDS</subject><subject>Ileum - radiation effects</subject><subject>INFORMATION</subject><subject>INTESTINAL ABSORPTION</subject><subject>Intestinal Absorption - radiation effects</subject><subject>IONIZING RADIATIONS</subject><subject>ISOTOPES</subject><subject>Jejunum - radiation effects</subject><subject>KINETICS</subject><subject>MAMMALS</subject><subject>NUCLEI</subject><subject>NUMERICAL DATA</subject><subject>ODD-EVEN NUCLEI</subject><subject>ORGANIC ACIDS</subject><subject>ORGANIC COMPOUNDS</subject><subject>PERMEABILITY</subject><subject>RADIATION EFFECTS</subject><subject>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</subject><subject>RADIATIONS</subject><subject>RADIOISOTOPES</subject><subject>RATS</subject><subject>Rats, Inbred Strains</subject><subject>REACTION KINETICS</subject><subject>RODENTS</subject><subject>STEROIDS</subject><subject>STEROLS</subject><subject>Taurocholic Acid - metabolism</subject><subject>Tissues, organs and organisms biophysics</subject><subject>Unstirred water layer</subject><subject>UPTAKE</subject><subject>VERTEBRATES</subject><subject>YEARS LIVING RADIOISOTOPES 560152 -- Radiation Effects on Animals-- Animals</subject><issn>0360-3016</issn><issn>1879-355X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1rGzEQhkVoSZ00_6CFpZSQHjbV90cPhRLyYQjk0kJvQivNUrXrlSutQ_Lvq7WNj81FEppn3pl5B6F3BF8STORnzCRuWX1daP7JYGpMS4_QgmhlWibEz1docUDeoJNSfmOMCVH8GB1LxYQScoGWy3GCMsXRDc1mPbk_0KS-6eIAjfMxlC_Ndd-Dn-ZfeJogz6DrQlptU2LOLkQ3xTS-Ra97NxQ429-n6MfN9feru_b-4XZ59e2-9ZzzqaWdwlSHKhE60UuAztUCGksinMEg6imFdkqD6gwnnTIUM8F84IYG5np2ij7sdFNt2xYfJ_C_fBrH2qWVUiqqcYXOd9A6p7-bOqBdxeJhGNwIaVOsJoRiTOmLIGGGMrlV5DvQ51RKht6uc1y5_GwJtvM-7Gy2nc22mtvtPuys_36vv-lWEA5J-wXU-Md93BXvhj670cdywLRWsrpQsa87DKqzjxHyPDiMHkLM89whxf_38Q-5KqWE</recordid><startdate>19840101</startdate><enddate>19840101</enddate><creator>Thomson, A.B.R.</creator><creator>Cheeseman, C.I.</creator><creator>Walker, K.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>19840101</creationdate><title>Intestinal uptake of bile acids: Effect of external abdominal irradiation</title><author>Thomson, A.B.R. ; Cheeseman, C.I. ; Walker, K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c444t-2b7028dabddb5f6eebaffe80615a90e55a9658a78e7b941b7920353cd492d3af3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>ABDOMEN</topic><topic>Abdomen - radiation effects</topic><topic>ABSORPTION</topic><topic>ALKALI METAL ISOTOPES</topic><topic>ANIMALS</topic><topic>BETA DECAY RADIOISOTOPES</topic><topic>BETA-MINUS DECAY RADIOISOTOPES</topic><topic>BILE ACIDS</topic><topic>Bile Acids and Salts - metabolism</topic><topic>BIOCHEMICAL REACTION KINETICS</topic><topic>Biological and medical sciences</topic><topic>BIOLOGICAL EFFECTS</topic><topic>Biological effects of radiation</topic><topic>BIOLOGICAL RADIATION EFFECTS</topic><topic>BODY</topic><topic>BODY AREAS</topic><topic>CARBOXYLIC ACIDS</topic><topic>CESIUM 137</topic><topic>CESIUM ISOTOPES</topic><topic>Cesium Radioisotopes</topic><topic>Chenodeoxycholic Acid - metabolism</topic><topic>Cholic Acid</topic><topic>Cholic Acids - metabolism</topic><topic>Colon - radiation effects</topic><topic>DATA</topic><topic>ELECTROMAGNETIC RADIATION</topic><topic>EXPERIMENTAL DATA</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GAMMA RADIATION</topic><topic>Glycochenodeoxycholic Acid - metabolism</topic><topic>Glycocholic Acid - metabolism</topic><topic>HYDROXY COMPOUNDS</topic><topic>Ileum - radiation effects</topic><topic>INFORMATION</topic><topic>INTESTINAL ABSORPTION</topic><topic>Intestinal Absorption - radiation effects</topic><topic>IONIZING RADIATIONS</topic><topic>ISOTOPES</topic><topic>Jejunum - radiation effects</topic><topic>KINETICS</topic><topic>MAMMALS</topic><topic>NUCLEI</topic><topic>NUMERICAL DATA</topic><topic>ODD-EVEN NUCLEI</topic><topic>ORGANIC ACIDS</topic><topic>ORGANIC COMPOUNDS</topic><topic>PERMEABILITY</topic><topic>RADIATION EFFECTS</topic><topic>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</topic><topic>RADIATIONS</topic><topic>RADIOISOTOPES</topic><topic>RATS</topic><topic>Rats, Inbred Strains</topic><topic>REACTION KINETICS</topic><topic>RODENTS</topic><topic>STEROIDS</topic><topic>STEROLS</topic><topic>Taurocholic Acid - metabolism</topic><topic>Tissues, organs and organisms biophysics</topic><topic>Unstirred water layer</topic><topic>UPTAKE</topic><topic>VERTEBRATES</topic><topic>YEARS LIVING RADIOISOTOPES 560152 -- Radiation Effects on Animals-- Animals</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thomson, A.B.R.</creatorcontrib><creatorcontrib>Cheeseman, C.I.</creatorcontrib><creatorcontrib>Walker, K.</creatorcontrib><creatorcontrib>Univ. of Alberta, Edmonton</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Int. J. Radiat. Oncol., Biol. Phys.; (United States)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thomson, A.B.R.</au><au>Cheeseman, C.I.</au><au>Walker, K.</au><aucorp>Univ. of Alberta, Edmonton</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intestinal uptake of bile acids: Effect of external abdominal irradiation</atitle><jtitle>Int. J. Radiat. Oncol., Biol. Phys.; (United States)</jtitle><addtitle>Int J Radiat Oncol Biol Phys</addtitle><date>1984-01-01</date><risdate>1984</risdate><volume>10</volume><issue>5</issue><spage>671</spage><epage>685</epage><pages>671-685</pages><issn>0360-3016</issn><eissn>1879-355X</eissn><coden>IOBPD3</coden><abstract>Abdominal irradiation has recently been shown to influence the uptake of hexoses, amino acids, fatty acids and cholesterol into the jejunum of rats. The present studies were undertaken with a previously validated
in vitro technique to determine the effect of abdominal irradiation from a cesium
137 source on the rates of uptake of six bile acids into the jejunum, ileum, and colon. In the ileum of control rats, there were marked differences in the value of the apparent Michaelis constant (Km
∗), maximal transport rate (J
d
m), and apparent passive permeability coefficient (Pd
∗) between cholic (C), glycocholic (GC), taurocholic (TC), chenodeoxycholic (CDC), and glycochenodeoxycholic (GCDC), and deoxycholic (DC) acid. The Km
∗ for each bile acid except. DC was lower three and 14 days after 600 rad, whereas the J
d
m for GC fell, but rose for TC, CDC, GCDC and DC and was unchanged for C. The Pd
∗ rose for C, GC, and DC, fell for TC and CDC, but remained unchanged for GCDC 14 days after irradiation. After 600 rad the value of Pd
∗ in the colon was increased at day 3 and 14 for CDC and GCDC, but was unchanged for GC and TC and was decreased for C. The uptake of bile acids was also affected by 300 rad and by 900 rad, but the direction and magnitude of the change was influenced by the intestinal site, the dose of irradiation, and the type of bile acid. The results show that: 1) there likely are multiple ileal carriers for bile acids; 2) abdominal irradiation has a variable effect on these carriers; 3) the passive permeability to bile acids varies with the bile acid and with the site along the intestine; and 4) abdominal irradiation is associated with a rise in the colonic permeability to only some bile acids.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>6735756</pmid><doi>10.1016/0360-3016(84)90299-2</doi><tpages>15</tpages></addata></record> |
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| ispartof | Int. J. Radiat. Oncol., Biol. Phys.; (United States), 1984-01, Vol.10 (5), p.671-685 |
| issn | 0360-3016 1879-355X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_81120022 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | ABDOMEN Abdomen - radiation effects ABSORPTION ALKALI METAL ISOTOPES ANIMALS BETA DECAY RADIOISOTOPES BETA-MINUS DECAY RADIOISOTOPES BILE ACIDS Bile Acids and Salts - metabolism BIOCHEMICAL REACTION KINETICS Biological and medical sciences BIOLOGICAL EFFECTS Biological effects of radiation BIOLOGICAL RADIATION EFFECTS BODY BODY AREAS CARBOXYLIC ACIDS CESIUM 137 CESIUM ISOTOPES Cesium Radioisotopes Chenodeoxycholic Acid - metabolism Cholic Acid Cholic Acids - metabolism Colon - radiation effects DATA ELECTROMAGNETIC RADIATION EXPERIMENTAL DATA Female Fundamental and applied biological sciences. Psychology GAMMA RADIATION Glycochenodeoxycholic Acid - metabolism Glycocholic Acid - metabolism HYDROXY COMPOUNDS Ileum - radiation effects INFORMATION INTESTINAL ABSORPTION Intestinal Absorption - radiation effects IONIZING RADIATIONS ISOTOPES Jejunum - radiation effects KINETICS MAMMALS NUCLEI NUMERICAL DATA ODD-EVEN NUCLEI ORGANIC ACIDS ORGANIC COMPOUNDS PERMEABILITY RADIATION EFFECTS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIATIONS RADIOISOTOPES RATS Rats, Inbred Strains REACTION KINETICS RODENTS STEROIDS STEROLS Taurocholic Acid - metabolism Tissues, organs and organisms biophysics Unstirred water layer UPTAKE VERTEBRATES YEARS LIVING RADIOISOTOPES 560152 -- Radiation Effects on Animals-- Animals |
| title | Intestinal uptake of bile acids: Effect of external abdominal irradiation |
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