A comparison of the antifibrillatory effect of midazolam and flunitrazepam in acute myocardial ischaemia in the dog
Summary A study was carried out using a model of myocardial ischaemia in the dog after ligation of the left coronary artery to determine the effects of the benzodiazepines, flunitrazepam and midazolam, on the ventricular fibrillation threshold. The fibrillation threshold was measured twice within 15...
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| Veröffentlicht in: | Current medical research and opinion 1987, Vol.10 (8), p.527-530 |
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| creator | Hess, L. Vrána, M. Vránová, Z. Fejfar, Z. |
| description | Summary
A study was carried out using a model of myocardial ischaemia in the dog after ligation of the left coronary artery to determine the effects of the benzodiazepines, flunitrazepam and midazolam, on the ventricular fibrillation threshold. The fibrillation threshold was measured twice within 15 min and 8 min after ligation. Fifteen minutes after the onset ofischaemic heart attack, 1.2 mg midazolam/kg or 0.25 mg flunitrazepam and midazolam, on the ventricular fibrillation threshold. The fibrillation threshold was measured twice within 15 min and 8 min after ligation. Fifteen minutes after the onset ofischaemic heart attack, 1.2 mg midazolam/kg or 0.25 mg of ischaemia. Their effects on haemodynamics were negligible. It is suggested that both benzodiazepines can be used for increasing electrical stability of the heart in patients with acute myocardial infarction and to inhibit the psychic stress response. Because of its short biological half-life and water solubility, allowing painless intravenous administration, midazolam offers a more flexible approach to pharmacotherapy immediately after acute heart attack according to the patient's current clinical status. |
| doi_str_mv | 10.1185/03007998709108961 |
| format | Article |
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A study was carried out using a model of myocardial ischaemia in the dog after ligation of the left coronary artery to determine the effects of the benzodiazepines, flunitrazepam and midazolam, on the ventricular fibrillation threshold. The fibrillation threshold was measured twice within 15 min and 8 min after ligation. Fifteen minutes after the onset ofischaemic heart attack, 1.2 mg midazolam/kg or 0.25 mg flunitrazepam and midazolam, on the ventricular fibrillation threshold. The fibrillation threshold was measured twice within 15 min and 8 min after ligation. Fifteen minutes after the onset ofischaemic heart attack, 1.2 mg midazolam/kg or 0.25 mg of ischaemia. Their effects on haemodynamics were negligible. It is suggested that both benzodiazepines can be used for increasing electrical stability of the heart in patients with acute myocardial infarction and to inhibit the psychic stress response. Because of its short biological half-life and water solubility, allowing painless intravenous administration, midazolam offers a more flexible approach to pharmacotherapy immediately after acute heart attack according to the patient's current clinical status.</description><identifier>ISSN: 0300-7995</identifier><identifier>EISSN: 1473-4877</identifier><identifier>DOI: 10.1185/03007998709108961</identifier><identifier>PMID: 3677787</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>animal ; Animals ; Anti-Arrhythmia Agents ; Coronary Vessels ; disease models ; Dogs ; flunitrazepam ; Flunitrazepam - pharmacology ; Heart Ventricles ; Ligation ; Male ; Midazolam ; Midazolam - pharmacology ; myocardial infarction ; Myocardial Infarction - drug therapy ; ventricular fibrillation</subject><ispartof>Current medical research and opinion, 1987, Vol.10 (8), p.527-530</ispartof><rights>1987 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1987</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c316t-ebdf3bacd86572687082ad33af4c3078b09ac3d2ea04d942732354b88a377c543</citedby><cites>FETCH-LOGICAL-c316t-ebdf3bacd86572687082ad33af4c3078b09ac3d2ea04d942732354b88a377c543</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1185/03007998709108961$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1185/03007998709108961$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,780,784,4022,27921,27922,27923,59645,59751,60434,60540,61219,61254,61400,61435</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3677787$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hess, L.</creatorcontrib><creatorcontrib>Vrána, M.</creatorcontrib><creatorcontrib>Vránová, Z.</creatorcontrib><creatorcontrib>Fejfar, Z.</creatorcontrib><title>A comparison of the antifibrillatory effect of midazolam and flunitrazepam in acute myocardial ischaemia in the dog</title><title>Current medical research and opinion</title><addtitle>Curr Med Res Opin</addtitle><description>Summary
A study was carried out using a model of myocardial ischaemia in the dog after ligation of the left coronary artery to determine the effects of the benzodiazepines, flunitrazepam and midazolam, on the ventricular fibrillation threshold. The fibrillation threshold was measured twice within 15 min and 8 min after ligation. Fifteen minutes after the onset ofischaemic heart attack, 1.2 mg midazolam/kg or 0.25 mg flunitrazepam and midazolam, on the ventricular fibrillation threshold. The fibrillation threshold was measured twice within 15 min and 8 min after ligation. Fifteen minutes after the onset ofischaemic heart attack, 1.2 mg midazolam/kg or 0.25 mg of ischaemia. Their effects on haemodynamics were negligible. It is suggested that both benzodiazepines can be used for increasing electrical stability of the heart in patients with acute myocardial infarction and to inhibit the psychic stress response. Because of its short biological half-life and water solubility, allowing painless intravenous administration, midazolam offers a more flexible approach to pharmacotherapy immediately after acute heart attack according to the patient's current clinical status.</description><subject>animal</subject><subject>Animals</subject><subject>Anti-Arrhythmia Agents</subject><subject>Coronary Vessels</subject><subject>disease models</subject><subject>Dogs</subject><subject>flunitrazepam</subject><subject>Flunitrazepam - pharmacology</subject><subject>Heart Ventricles</subject><subject>Ligation</subject><subject>Male</subject><subject>Midazolam</subject><subject>Midazolam - pharmacology</subject><subject>myocardial infarction</subject><subject>Myocardial Infarction - drug therapy</subject><subject>ventricular fibrillation</subject><issn>0300-7995</issn><issn>1473-4877</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9r3DAQxUVJSTdpP0APBZ1ycytZtiWTXEJom0Kgl_YsxvrTVZCsrSQTNp8-MrsEQiCngfm995h5CH2m5Culov9GGCF8HAUnIyViHOg7tKEdZ00nOD9Bm5U3VdB_QGc53xNCWzGOp-iUDZxzwTcoX2MVww6Sy3HG0eKyNRjm4qybkvMeSkx7bKw1qqw4OA2P0UOoIo2tX2ZXEjyaXd24GYNaisFhHxUk7cBjl9UWTHCw0jVbx38f0XsLPptPx3mO_v74_ufmtrn7_fPXzfVdoxgdSmMmbdkESouh5-1QnxQtaMbAdooRLiYygmK6NUA6PXYtZy3ru0kIYJyrvmPn6OKQu0vx_2JykaGeY-pTs4lLloJSOgixCulBqFLMORkrd8kFSHtJiVyLlq-Krp4vx_BlCkY_O47NVn514G62MQV4iMlrWWDvY7IJZuWyZG_FX76wbw34sq2tGnkflzTX3t447gmB0Z99</recordid><startdate>1987</startdate><enddate>1987</enddate><creator>Hess, L.</creator><creator>Vrána, M.</creator><creator>Vránová, Z.</creator><creator>Fejfar, Z.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1987</creationdate><title>A comparison of the antifibrillatory effect of midazolam and flunitrazepam in acute myocardial ischaemia in the dog</title><author>Hess, L. ; Vrána, M. ; Vránová, Z. ; Fejfar, Z.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c316t-ebdf3bacd86572687082ad33af4c3078b09ac3d2ea04d942732354b88a377c543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>animal</topic><topic>Animals</topic><topic>Anti-Arrhythmia Agents</topic><topic>Coronary Vessels</topic><topic>disease models</topic><topic>Dogs</topic><topic>flunitrazepam</topic><topic>Flunitrazepam - pharmacology</topic><topic>Heart Ventricles</topic><topic>Ligation</topic><topic>Male</topic><topic>Midazolam</topic><topic>Midazolam - pharmacology</topic><topic>myocardial infarction</topic><topic>Myocardial Infarction - drug therapy</topic><topic>ventricular fibrillation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hess, L.</creatorcontrib><creatorcontrib>Vrána, M.</creatorcontrib><creatorcontrib>Vránová, Z.</creatorcontrib><creatorcontrib>Fejfar, Z.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Current medical research and opinion</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hess, L.</au><au>Vrána, M.</au><au>Vránová, Z.</au><au>Fejfar, Z.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A comparison of the antifibrillatory effect of midazolam and flunitrazepam in acute myocardial ischaemia in the dog</atitle><jtitle>Current medical research and opinion</jtitle><addtitle>Curr Med Res Opin</addtitle><date>1987</date><risdate>1987</risdate><volume>10</volume><issue>8</issue><spage>527</spage><epage>530</epage><pages>527-530</pages><issn>0300-7995</issn><eissn>1473-4877</eissn><abstract>Summary
A study was carried out using a model of myocardial ischaemia in the dog after ligation of the left coronary artery to determine the effects of the benzodiazepines, flunitrazepam and midazolam, on the ventricular fibrillation threshold. The fibrillation threshold was measured twice within 15 min and 8 min after ligation. Fifteen minutes after the onset ofischaemic heart attack, 1.2 mg midazolam/kg or 0.25 mg flunitrazepam and midazolam, on the ventricular fibrillation threshold. The fibrillation threshold was measured twice within 15 min and 8 min after ligation. Fifteen minutes after the onset ofischaemic heart attack, 1.2 mg midazolam/kg or 0.25 mg of ischaemia. Their effects on haemodynamics were negligible. It is suggested that both benzodiazepines can be used for increasing electrical stability of the heart in patients with acute myocardial infarction and to inhibit the psychic stress response. Because of its short biological half-life and water solubility, allowing painless intravenous administration, midazolam offers a more flexible approach to pharmacotherapy immediately after acute heart attack according to the patient's current clinical status.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>3677787</pmid><doi>10.1185/03007998709108961</doi><tpages>4</tpages></addata></record> |
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| ispartof | Current medical research and opinion, 1987, Vol.10 (8), p.527-530 |
| issn | 0300-7995 1473-4877 |
| language | eng |
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| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | animal Animals Anti-Arrhythmia Agents Coronary Vessels disease models Dogs flunitrazepam Flunitrazepam - pharmacology Heart Ventricles Ligation Male Midazolam Midazolam - pharmacology myocardial infarction Myocardial Infarction - drug therapy ventricular fibrillation |
| title | A comparison of the antifibrillatory effect of midazolam and flunitrazepam in acute myocardial ischaemia in the dog |
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