Methotrexate and 7-hydroxy-methotrexate pharmacokinetics following intravenous bolus administration and high-dose infusion of methotrexate

The pharmacokinetics of methotrexate and 7-hydroxy-methotrexate were studied in patients undergoing very high-dose methotrexate monotherapy. The patients received, first, two methotrexate intravenous bolus test doses (50 mg/m 2 ) one with and one without concomitant administration of folinic acid (1...

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Veröffentlicht in:	European journal of cancer & clinical oncology 1987-09, Vol.23 (9), p.1385-1390
Hauptverfasser:	Bore, Patrick, Bruno, Rene, Lena, Nicole, Favre, Roger, Cano, Jean Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Antineoplastic agents Biological and medical sciences Chemotherapy Female Humans Infusions, Intravenous Injections, Intravenous Leucovorin - therapeutic use Male Medical sciences Methotrexate - administration & dosage Methotrexate - analogs & derivatives Methotrexate - blood Methotrexate - pharmacokinetics Middle Aged Models, Biological Pharmacology. Drug treatments Time Factors
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