Pregnancy-related changes in the connective tissue of the ovine cervix
During the course of gestation, changes in the metabolism and chemical composition of the cervical connective tissue occur. The concentrations of collagen, proteoglycan and hyaluronate in the cervix decrease with time of pregnancy, while there is a small but significant increase in tissue hydration....
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| Veröffentlicht in: | Biology of reproduction 1984-06, Vol.30 (5), p.1223-1235 |
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| creator | Fosang, A.J Handley, C.J Santer, V Lowther, D.A Thorburn, G.D |
| description | During the course of gestation, changes in the metabolism and chemical composition of the cervical connective tissue occur.
The concentrations of collagen, proteoglycan and hyaluronate in the cervix decrease with time of pregnancy, while there is
a small but significant increase in tissue hydration. The collagen network loses its dense, ordered appearance and assumes
a loose, frayed, disoriented structure. A small molecular weight dermatan sulphate proteoglycan with Kav = 0.48 on Sepharose
CL-4B has been isolated from pregnant and nonpregnant ovine cervix. Proteoglycans isolated from dilated cervix yield a second
peak at the excluded volume of a Sepharose CL-4B column which may represent a new proteoglycan species, or represent a proteoglycan
monomer with larger glycosaminoglycan constituents. The rate of synthesis of proteoglycan is enhanced during pregnancy, and
doubles in the time between 140 days and term (dilated). The increased rate of proteoglycan synthesis in the presence of a
diminishing hexuronate concentration in the pregnant cervix is indicative of enhanced proteoglycan turnover. This may provide
some insight into the mechanism whereby a new matrix with altered mechanical properties is produced, since a rapid turnover
of matrix components enables a remodeling of the connective tissue framework. This reorganization of the matrix is discussed
with respect to parturition. |
| doi_str_mv | 10.1095/biolreprod30.5.1223 |
| format | Article |
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The concentrations of collagen, proteoglycan and hyaluronate in the cervix decrease with time of pregnancy, while there is
a small but significant increase in tissue hydration. The collagen network loses its dense, ordered appearance and assumes
a loose, frayed, disoriented structure. A small molecular weight dermatan sulphate proteoglycan with Kav = 0.48 on Sepharose
CL-4B has been isolated from pregnant and nonpregnant ovine cervix. Proteoglycans isolated from dilated cervix yield a second
peak at the excluded volume of a Sepharose CL-4B column which may represent a new proteoglycan species, or represent a proteoglycan
monomer with larger glycosaminoglycan constituents. The rate of synthesis of proteoglycan is enhanced during pregnancy, and
doubles in the time between 140 days and term (dilated). The increased rate of proteoglycan synthesis in the presence of a
diminishing hexuronate concentration in the pregnant cervix is indicative of enhanced proteoglycan turnover. This may provide
some insight into the mechanism whereby a new matrix with altered mechanical properties is produced, since a rapid turnover
of matrix components enables a remodeling of the connective tissue framework. This reorganization of the matrix is discussed
with respect to parturition.</description><identifier>ISSN: 0006-3363</identifier><identifier>EISSN: 1529-7268</identifier><identifier>DOI: 10.1095/biolreprod30.5.1223</identifier><identifier>PMID: 6733211</identifier><identifier>CODEN: BIREBV</identifier><language>eng</language><publisher>Madison, WI: Society for the Study of Reproduction</publisher><subject>Animals ; Biological and medical sciences ; Body Water - metabolism ; BREBIS ; Cervix Uteri - anatomy & histology ; Cervix Uteri - metabolism ; Chondroitin - analogs & derivatives ; Chondroitin Sulfate Proteoglycans - isolation & purification ; Connective Tissue - analysis ; Connective Tissue - metabolism ; Connective Tissue - ultrastructure ; CONNECTIVE TISSUES ; Dermatan Sulfate - isolation & purification ; EWES ; Female ; Fundamental and applied biological sciences. Psychology ; Glycosaminoglycans - biosynthesis ; Hexuronic Acids - analysis ; Hydroxyproline - analysis ; Mammalian female genital system ; Morphology. Physiology ; OVEJA ; Pregnancy ; Pregnancy, Animal ; Proteoglycans - biosynthesis ; Proteoglycans - isolation & purification ; Sheep ; TEJIDO CONJUNTIVO ; TISSU CONJONCTIF ; UTERO ; UTERUS ; Vertebrates: reproduction</subject><ispartof>Biology of reproduction, 1984-06, Vol.30 (5), p.1223-1235</ispartof><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-97876615cb6c75ff790b02b3a9e7dbef03c573a5af232f69f7a316751060d6b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9085502$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6733211$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fosang, A.J</creatorcontrib><creatorcontrib>Handley, C.J</creatorcontrib><creatorcontrib>Santer, V</creatorcontrib><creatorcontrib>Lowther, D.A</creatorcontrib><creatorcontrib>Thorburn, G.D</creatorcontrib><title>Pregnancy-related changes in the connective tissue of the ovine cervix</title><title>Biology of reproduction</title><addtitle>Biol Reprod</addtitle><description>During the course of gestation, changes in the metabolism and chemical composition of the cervical connective tissue occur.
The concentrations of collagen, proteoglycan and hyaluronate in the cervix decrease with time of pregnancy, while there is
a small but significant increase in tissue hydration. The collagen network loses its dense, ordered appearance and assumes
a loose, frayed, disoriented structure. A small molecular weight dermatan sulphate proteoglycan with Kav = 0.48 on Sepharose
CL-4B has been isolated from pregnant and nonpregnant ovine cervix. Proteoglycans isolated from dilated cervix yield a second
peak at the excluded volume of a Sepharose CL-4B column which may represent a new proteoglycan species, or represent a proteoglycan
monomer with larger glycosaminoglycan constituents. The rate of synthesis of proteoglycan is enhanced during pregnancy, and
doubles in the time between 140 days and term (dilated). The increased rate of proteoglycan synthesis in the presence of a
diminishing hexuronate concentration in the pregnant cervix is indicative of enhanced proteoglycan turnover. This may provide
some insight into the mechanism whereby a new matrix with altered mechanical properties is produced, since a rapid turnover
of matrix components enables a remodeling of the connective tissue framework. This reorganization of the matrix is discussed
with respect to parturition.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Body Water - metabolism</subject><subject>BREBIS</subject><subject>Cervix Uteri - anatomy & histology</subject><subject>Cervix Uteri - metabolism</subject><subject>Chondroitin - analogs & derivatives</subject><subject>Chondroitin Sulfate Proteoglycans - isolation & purification</subject><subject>Connective Tissue - analysis</subject><subject>Connective Tissue - metabolism</subject><subject>Connective Tissue - ultrastructure</subject><subject>CONNECTIVE TISSUES</subject><subject>Dermatan Sulfate - isolation & purification</subject><subject>EWES</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glycosaminoglycans - biosynthesis</subject><subject>Hexuronic Acids - analysis</subject><subject>Hydroxyproline - analysis</subject><subject>Mammalian female genital system</subject><subject>Morphology. Physiology</subject><subject>OVEJA</subject><subject>Pregnancy</subject><subject>Pregnancy, Animal</subject><subject>Proteoglycans - biosynthesis</subject><subject>Proteoglycans - isolation & purification</subject><subject>Sheep</subject><subject>TEJIDO CONJUNTIVO</subject><subject>TISSU CONJONCTIF</subject><subject>UTERO</subject><subject>UTERUS</subject><subject>Vertebrates: reproduction</subject><issn>0006-3363</issn><issn>1529-7268</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkM1u2zAQhImiQeq4fYEWBXQocpO75JqkdCyC5gcIkABxzwRFLW0WspSSsp28fZjaSHzaw8zO7nyMfeMw41DLn00YukiPcWgRZnLGhcAPbMKlqEstVPWRTQBAlYgKP7GzlP4C8DkKPGWnSiMKzifs8j7Ssre9ey4jdXaktnAr2y8pFaEvxhUVbuh7cmPYUjGGlDZUDP6_MGxDn2WK2_D0mZ142yX6cphTtrj8vbi4Lm_vrm4uft2Wbj6XY1nrSivFpWuU09J7XUMDokFbk24b8oBOarTSeoHCq9pri1xpyUFBqxqcsvN9bC79b0NpNOuQHHWd7WnYJFNxzoXMJacM90YXh5QiefMYw9rGZ8PBvMIzx_CMNK_w8tb3Q_ymWVP7tnOglfUfB90mZzsfM7eQ3mw1VFKCeP9yFZarXYhk0tp2XQ5Fs9vtju993Ru9HYxdxpz156FSkFtU-AK3949J</recordid><startdate>198406</startdate><enddate>198406</enddate><creator>Fosang, A.J</creator><creator>Handley, C.J</creator><creator>Santer, V</creator><creator>Lowther, D.A</creator><creator>Thorburn, G.D</creator><general>Society for the Study of Reproduction</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198406</creationdate><title>Pregnancy-related changes in the connective tissue of the ovine cervix</title><author>Fosang, A.J ; Handley, C.J ; Santer, V ; Lowther, D.A ; Thorburn, G.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-97876615cb6c75ff790b02b3a9e7dbef03c573a5af232f69f7a316751060d6b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Body Water - metabolism</topic><topic>BREBIS</topic><topic>Cervix Uteri - anatomy & histology</topic><topic>Cervix Uteri - metabolism</topic><topic>Chondroitin - analogs & derivatives</topic><topic>Chondroitin Sulfate Proteoglycans - isolation & purification</topic><topic>Connective Tissue - analysis</topic><topic>Connective Tissue - metabolism</topic><topic>Connective Tissue - ultrastructure</topic><topic>CONNECTIVE TISSUES</topic><topic>Dermatan Sulfate - isolation & purification</topic><topic>EWES</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glycosaminoglycans - biosynthesis</topic><topic>Hexuronic Acids - analysis</topic><topic>Hydroxyproline - analysis</topic><topic>Mammalian female genital system</topic><topic>Morphology. Physiology</topic><topic>OVEJA</topic><topic>Pregnancy</topic><topic>Pregnancy, Animal</topic><topic>Proteoglycans - biosynthesis</topic><topic>Proteoglycans - isolation & purification</topic><topic>Sheep</topic><topic>TEJIDO CONJUNTIVO</topic><topic>TISSU CONJONCTIF</topic><topic>UTERO</topic><topic>UTERUS</topic><topic>Vertebrates: reproduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fosang, A.J</creatorcontrib><creatorcontrib>Handley, C.J</creatorcontrib><creatorcontrib>Santer, V</creatorcontrib><creatorcontrib>Lowther, D.A</creatorcontrib><creatorcontrib>Thorburn, G.D</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biology of reproduction</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fosang, A.J</au><au>Handley, C.J</au><au>Santer, V</au><au>Lowther, D.A</au><au>Thorburn, G.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pregnancy-related changes in the connective tissue of the ovine cervix</atitle><jtitle>Biology of reproduction</jtitle><addtitle>Biol Reprod</addtitle><date>1984-06</date><risdate>1984</risdate><volume>30</volume><issue>5</issue><spage>1223</spage><epage>1235</epage><pages>1223-1235</pages><issn>0006-3363</issn><eissn>1529-7268</eissn><coden>BIREBV</coden><abstract>During the course of gestation, changes in the metabolism and chemical composition of the cervical connective tissue occur.
The concentrations of collagen, proteoglycan and hyaluronate in the cervix decrease with time of pregnancy, while there is
a small but significant increase in tissue hydration. The collagen network loses its dense, ordered appearance and assumes
a loose, frayed, disoriented structure. A small molecular weight dermatan sulphate proteoglycan with Kav = 0.48 on Sepharose
CL-4B has been isolated from pregnant and nonpregnant ovine cervix. Proteoglycans isolated from dilated cervix yield a second
peak at the excluded volume of a Sepharose CL-4B column which may represent a new proteoglycan species, or represent a proteoglycan
monomer with larger glycosaminoglycan constituents. The rate of synthesis of proteoglycan is enhanced during pregnancy, and
doubles in the time between 140 days and term (dilated). The increased rate of proteoglycan synthesis in the presence of a
diminishing hexuronate concentration in the pregnant cervix is indicative of enhanced proteoglycan turnover. This may provide
some insight into the mechanism whereby a new matrix with altered mechanical properties is produced, since a rapid turnover
of matrix components enables a remodeling of the connective tissue framework. This reorganization of the matrix is discussed
with respect to parturition.</abstract><cop>Madison, WI</cop><pub>Society for the Study of Reproduction</pub><pmid>6733211</pmid><doi>10.1095/biolreprod30.5.1223</doi><tpages>13</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Biology of reproduction, 1984-06, Vol.30 (5), p.1223-1235 |
| issn | 0006-3363 1529-7268 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_81112514 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Biological and medical sciences Body Water - metabolism BREBIS Cervix Uteri - anatomy & histology Cervix Uteri - metabolism Chondroitin - analogs & derivatives Chondroitin Sulfate Proteoglycans - isolation & purification Connective Tissue - analysis Connective Tissue - metabolism Connective Tissue - ultrastructure CONNECTIVE TISSUES Dermatan Sulfate - isolation & purification EWES Female Fundamental and applied biological sciences. Psychology Glycosaminoglycans - biosynthesis Hexuronic Acids - analysis Hydroxyproline - analysis Mammalian female genital system Morphology. Physiology OVEJA Pregnancy Pregnancy, Animal Proteoglycans - biosynthesis Proteoglycans - isolation & purification Sheep TEJIDO CONJUNTIVO TISSU CONJONCTIF UTERO UTERUS Vertebrates: reproduction |
| title | Pregnancy-related changes in the connective tissue of the ovine cervix |
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