Drug modulation of chromosomal protein subtypes during specific phases of the submaxillary cell cycle
The H 1 subtype proteins a, b, c, d, e, and 1 ∘ and the high mobility group (HMG) proteins 14 and 17 were extracted from submaxillary gland (SMG) nuclei treated in vivo and sorted from specific phases of the cell cycle, and analyzed by gel electrophoresis. Significant differences in these proteins w...
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| Veröffentlicht in: | Cell biology international reports 1984-01, Vol.8 (4), p.279-287 |
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| creator | Pipkin, J.L. Anson, J.F. Hinson, W.G. Burns, E.R. |
| description | The H
1 subtype proteins a, b, c, d, e, and 1 ∘ and the high mobility group (HMG) proteins 14 and 17 were extracted from submaxillary gland (SMG) nuclei treated
in vivo
and sorted from specific phases of the cell cycle, and analyzed by gel electrophoresis. Significant differences in these proteins were noted between quiescent (G
0) phase nuclei and proliferating nuclei in both stained and autoradiographic gels. Stimulation of the SMG into cell division with DL-isoproterenol-HCl alone or in conjunction with sodium phenobarbital (PB) provided a system, for the analysis of drug effects in stained,
3H lysine, and
32P pulse-labeled nuclear proteins obtained from different phases of the cell cycle. |
| doi_str_mv | 10.1016/0309-1651(84)90154-1 |
| format | Article |
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1 subtype proteins a, b, c, d, e, and 1 ∘ and the high mobility group (HMG) proteins 14 and 17 were extracted from submaxillary gland (SMG) nuclei treated
in vivo
and sorted from specific phases of the cell cycle, and analyzed by gel electrophoresis. Significant differences in these proteins were noted between quiescent (G
0) phase nuclei and proliferating nuclei in both stained and autoradiographic gels. Stimulation of the SMG into cell division with DL-isoproterenol-HCl alone or in conjunction with sodium phenobarbital (PB) provided a system, for the analysis of drug effects in stained,
3H lysine, and
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1 subtype proteins a, b, c, d, e, and 1 ∘ and the high mobility group (HMG) proteins 14 and 17 were extracted from submaxillary gland (SMG) nuclei treated
in vivo
and sorted from specific phases of the cell cycle, and analyzed by gel electrophoresis. Significant differences in these proteins were noted between quiescent (G
0) phase nuclei and proliferating nuclei in both stained and autoradiographic gels. Stimulation of the SMG into cell division with DL-isoproterenol-HCl alone or in conjunction with sodium phenobarbital (PB) provided a system, for the analysis of drug effects in stained,
3H lysine, and
32P pulse-labeled nuclear proteins obtained from different phases of the cell cycle.</description><subject>Animals</subject><subject>Autoradiography</subject><subject>Biological and medical sciences</subject><subject>Cell Cycle - drug effects</subject><subject>Cell cycle, cell proliferation</subject><subject>Cell physiology</subject><subject>Chromatography, Gel</subject><subject>Chromosomal Proteins, Non-Histone - analysis</subject><subject>Chromosomal Proteins, Non-Histone - metabolism</subject><subject>Electrophoresis, Polyacrylamide Gel</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>High Mobility Group Proteins</subject><subject>Isoproterenol - pharmacology</subject><subject>Molecular and cellular biology</subject><subject>Phenobarbital - pharmacology</subject><subject>Phosphorylation</subject><subject>Rats</subject><subject>Submandibular Gland - analysis</subject><subject>Submandibular Gland - cytology</subject><subject>Submandibular Gland - drug effects</subject><issn>0309-1651</issn><issn>1878-240X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU-r1TAQxYMoz-vVb6CQhYguqkmTtMnmgTz_wgM3Cu5COp2-G0mbmrTi_fam3std6mrIzO8MJ2cIecrZa85484YJZireKP5Sy1eGcSUrfo_suG51VUv2_T7ZXZCH5FHOP1h5C2WuyFVTC8lasSP4Lq13dIz9Gtzi40TjQOGQ4hhzHF2gc4oL-onmtVuOM2bar8lPdzTPCH7wQOeDy6VdZMsBN2x0v30ILh0pYAgUjhDwMXkwuJDxybnuybcP77_efKpuv3z8fPP2tgLJ26VSwjEOHTadBBASGEjsWwmmVRKd5Lo2ygjX1cZ1DnqjtFLQ14N0amgbrcWevDjtLbZ_rpgXO_q82XATxjVbzTmva9n8F-TCaC1bUUB5AiHFnBMOdk5-LL-znNntDHbL2G4ZWy3t3zMU9Z48O-8vgWB_EZ1zL_Pn57nL4MKQ3AQ-XzBtTKObzeb1CcMS2i-PyWbwOAH2PiEsto_-3z7-AFnvpRc</recordid><startdate>19840101</startdate><enddate>19840101</enddate><creator>Pipkin, J.L.</creator><creator>Anson, J.F.</creator><creator>Hinson, W.G.</creator><creator>Burns, E.R.</creator><general>Elsevier B.V</general><general>Academic Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7X8</scope></search><sort><creationdate>19840101</creationdate><title>Drug modulation of chromosomal protein subtypes during specific phases of the submaxillary cell cycle</title><author>Pipkin, J.L. ; Anson, J.F. ; Hinson, W.G. ; Burns, E.R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-53a01cbe6b4cc34c0c4ed74c9754ea41829593ab29abacd95855cd2f4a5f76883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Animals</topic><topic>Autoradiography</topic><topic>Biological and medical sciences</topic><topic>Cell Cycle - drug effects</topic><topic>Cell cycle, cell proliferation</topic><topic>Cell physiology</topic><topic>Chromatography, Gel</topic><topic>Chromosomal Proteins, Non-Histone - analysis</topic><topic>Chromosomal Proteins, Non-Histone - metabolism</topic><topic>Electrophoresis, Polyacrylamide Gel</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>High Mobility Group Proteins</topic><topic>Isoproterenol - pharmacology</topic><topic>Molecular and cellular biology</topic><topic>Phenobarbital - pharmacology</topic><topic>Phosphorylation</topic><topic>Rats</topic><topic>Submandibular Gland - analysis</topic><topic>Submandibular Gland - cytology</topic><topic>Submandibular Gland - drug effects</topic><toplevel>online_resources</toplevel><creatorcontrib>Pipkin, J.L.</creatorcontrib><creatorcontrib>Anson, J.F.</creatorcontrib><creatorcontrib>Hinson, W.G.</creatorcontrib><creatorcontrib>Burns, E.R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cell biology international reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pipkin, J.L.</au><au>Anson, J.F.</au><au>Hinson, W.G.</au><au>Burns, E.R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Drug modulation of chromosomal protein subtypes during specific phases of the submaxillary cell cycle</atitle><jtitle>Cell biology international reports</jtitle><addtitle>Cell Biol Int Rep</addtitle><date>1984-01-01</date><risdate>1984</risdate><volume>8</volume><issue>4</issue><spage>279</spage><epage>287</epage><pages>279-287</pages><issn>0309-1651</issn><eissn>1878-240X</eissn><coden>CBRPDS</coden><abstract>The H
1 subtype proteins a, b, c, d, e, and 1 ∘ and the high mobility group (HMG) proteins 14 and 17 were extracted from submaxillary gland (SMG) nuclei treated
in vivo
and sorted from specific phases of the cell cycle, and analyzed by gel electrophoresis. Significant differences in these proteins were noted between quiescent (G
0) phase nuclei and proliferating nuclei in both stained and autoradiographic gels. Stimulation of the SMG into cell division with DL-isoproterenol-HCl alone or in conjunction with sodium phenobarbital (PB) provided a system, for the analysis of drug effects in stained,
3H lysine, and
32P pulse-labeled nuclear proteins obtained from different phases of the cell cycle.</abstract><cop>London</cop><cop>San Diego, CA</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>6234073</pmid><doi>10.1016/0309-1651(84)90154-1</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Cell biology international reports, 1984-01, Vol.8 (4), p.279-287 |
| issn | 0309-1651 1878-240X |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Autoradiography Biological and medical sciences Cell Cycle - drug effects Cell cycle, cell proliferation Cell physiology Chromatography, Gel Chromosomal Proteins, Non-Histone - analysis Chromosomal Proteins, Non-Histone - metabolism Electrophoresis, Polyacrylamide Gel Fundamental and applied biological sciences. Psychology High Mobility Group Proteins Isoproterenol - pharmacology Molecular and cellular biology Phenobarbital - pharmacology Phosphorylation Rats Submandibular Gland - analysis Submandibular Gland - cytology Submandibular Gland - drug effects |
| title | Drug modulation of chromosomal protein subtypes during specific phases of the submaxillary cell cycle |
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