Infection with Feline Leukemia Virus Associated with Induction of Humoral Response to a Normal Cell Protein
Abstract Selected populations of cats that were naturally exposed to the feline leukemia virus (FeLV) were found to have humoral antibodies to a normal cell protein designated NCP105. Earlier studies revealed that cats exposed to FeLV often had serum antibodies to the feline oncornavirus-associated...
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| Veröffentlicht in: | Cancer investigation 1984, Vol.2 (2), p.81-90 |
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| container_title | Cancer investigation |
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| creator | Chen, Ann-Ping T. Essex, Myron E. |
| description | Abstract
Selected populations of cats that were naturally exposed to the feline leukemia virus (FeLV) were found to have humoral antibodies to a normal cell protein designated NCP105. Earlier studies revealed that cats exposed to FeLV often had serum antibodies to the feline oncornavirus-associated cell membrane (FOCMA) as well as to a feline sarcoma virus (FeSV)-specific transforming protein designated gag-fes. Cats with no history of exposure to FeLV or FeSV lacked antibodies to all three antigens: NCP105, FOCMA, and gag-fes. Following exposure to FeLV, cats develop antibodies to either NCP105 or to gag-fes and FOCMA, but not to both groups of antigens. NCP105 is present in both normal and transformed cells from a wide variety of species. It lacks peptide homology with gag-fes and it is not a phosphoprotein. The presence of antibodies to NCP105 in cats exposed to FeLV but not in unexposed cats suggests that FeLV may activate the NCP105 gene or increase the relative immunogenicity of this protein in vivo. |
| doi_str_mv | 10.3109/07357908409020290 |
| format | Article |
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Selected populations of cats that were naturally exposed to the feline leukemia virus (FeLV) were found to have humoral antibodies to a normal cell protein designated NCP105. Earlier studies revealed that cats exposed to FeLV often had serum antibodies to the feline oncornavirus-associated cell membrane (FOCMA) as well as to a feline sarcoma virus (FeSV)-specific transforming protein designated gag-fes. Cats with no history of exposure to FeLV or FeSV lacked antibodies to all three antigens: NCP105, FOCMA, and gag-fes. Following exposure to FeLV, cats develop antibodies to either NCP105 or to gag-fes and FOCMA, but not to both groups of antigens. NCP105 is present in both normal and transformed cells from a wide variety of species. It lacks peptide homology with gag-fes and it is not a phosphoprotein. The presence of antibodies to NCP105 in cats exposed to FeLV but not in unexposed cats suggests that FeLV may activate the NCP105 gene or increase the relative immunogenicity of this protein in vivo.</description><identifier>ISSN: 0735-7907</identifier><identifier>EISSN: 1532-4192</identifier><identifier>DOI: 10.3109/07357908409020290</identifier><identifier>PMID: 6329486</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Animals ; Antibodies, Viral - analysis ; Antibody Formation ; Antigens, Viral - immunology ; Cats ; Cell Transformation, Neoplastic ; feline leukemia virus ; Leukemia Virus, Feline - genetics ; Leukemia Virus, Feline - immunology ; Leukemia, Experimental - immunology ; Neoplasm Proteins - immunology ; Proteins - analysis ; Proteins - immunology</subject><ispartof>Cancer investigation, 1984, Vol.2 (2), p.81-90</ispartof><rights>1984 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1984</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c384t-1932b9172e9d830071ad66c62cdc2fead6a5af20ac1d4b5935d1a98479781de3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/07357908409020290$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/07357908409020290$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,777,781,4010,27904,27905,27906,59626,59732,60415,60521,61200,61235,61381,61416</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6329486$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Ann-Ping T.</creatorcontrib><creatorcontrib>Essex, Myron E.</creatorcontrib><title>Infection with Feline Leukemia Virus Associated with Induction of Humoral Response to a Normal Cell Protein</title><title>Cancer investigation</title><addtitle>Cancer Invest</addtitle><description>Abstract
Selected populations of cats that were naturally exposed to the feline leukemia virus (FeLV) were found to have humoral antibodies to a normal cell protein designated NCP105. Earlier studies revealed that cats exposed to FeLV often had serum antibodies to the feline oncornavirus-associated cell membrane (FOCMA) as well as to a feline sarcoma virus (FeSV)-specific transforming protein designated gag-fes. Cats with no history of exposure to FeLV or FeSV lacked antibodies to all three antigens: NCP105, FOCMA, and gag-fes. Following exposure to FeLV, cats develop antibodies to either NCP105 or to gag-fes and FOCMA, but not to both groups of antigens. NCP105 is present in both normal and transformed cells from a wide variety of species. It lacks peptide homology with gag-fes and it is not a phosphoprotein. The presence of antibodies to NCP105 in cats exposed to FeLV but not in unexposed cats suggests that FeLV may activate the NCP105 gene or increase the relative immunogenicity of this protein in vivo.</description><subject>Animals</subject><subject>Antibodies, Viral - analysis</subject><subject>Antibody Formation</subject><subject>Antigens, Viral - immunology</subject><subject>Cats</subject><subject>Cell Transformation, Neoplastic</subject><subject>feline leukemia virus</subject><subject>Leukemia Virus, Feline - genetics</subject><subject>Leukemia Virus, Feline - immunology</subject><subject>Leukemia, Experimental - immunology</subject><subject>Neoplasm Proteins - immunology</subject><subject>Proteins - analysis</subject><subject>Proteins - immunology</subject><issn>0735-7907</issn><issn>1532-4192</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV9LHDEUxUOp2NX2A_hQyFPfRvNnZpJgX2TRurBoKdLXIZvcYaMzyTbJIH77zjCLIKLmJSTndw6XcxE6oeSUU6LOiOCVUESWRBFGmCKf0IJWnBUlVewzWkx6MQLiCzpK6Z4QKpmoDtFhzZkqZb1ADyvfgskuePzo8hZfQec84DUMD9A7jf-6OCR8kVIwTmewM7XydphNocXXQx-i7vAfSLvgE-AcsMY3Ifbj5xK6Dv-OIYPzX9FBq7sE3_b3Mbq7urxbXhfr21-r5cW6MFyWuaCKs42igoGykhMiqLZ1bWpmrGEtjA9d6ZYRbagtN5XilaVayVIoIakFfox-zLG7GP4NkHLTu2TGObSHMKRG0vHIkn8I0pIIUfEJpDNoYkgpQtvsout1fGooaaZFNK8WMXq-78OHTQ_22bFvftR_zrrz7VTVY4idbbJ-6kJso_bGpSn67fjzF_Yt6C5vjY7Q3Ich-rHfd4b7D4yQqKM</recordid><startdate>1984</startdate><enddate>1984</enddate><creator>Chen, Ann-Ping T.</creator><creator>Essex, Myron E.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>1984</creationdate><title>Infection with Feline Leukemia Virus Associated with Induction of Humoral Response to a Normal Cell Protein</title><author>Chen, Ann-Ping T. ; Essex, Myron E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-1932b9172e9d830071ad66c62cdc2fead6a5af20ac1d4b5935d1a98479781de3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Animals</topic><topic>Antibodies, Viral - analysis</topic><topic>Antibody Formation</topic><topic>Antigens, Viral - immunology</topic><topic>Cats</topic><topic>Cell Transformation, Neoplastic</topic><topic>feline leukemia virus</topic><topic>Leukemia Virus, Feline - genetics</topic><topic>Leukemia Virus, Feline - immunology</topic><topic>Leukemia, Experimental - immunology</topic><topic>Neoplasm Proteins - immunology</topic><topic>Proteins - analysis</topic><topic>Proteins - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Ann-Ping T.</creatorcontrib><creatorcontrib>Essex, Myron E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Ann-Ping T.</au><au>Essex, Myron E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Infection with Feline Leukemia Virus Associated with Induction of Humoral Response to a Normal Cell Protein</atitle><jtitle>Cancer investigation</jtitle><addtitle>Cancer Invest</addtitle><date>1984</date><risdate>1984</risdate><volume>2</volume><issue>2</issue><spage>81</spage><epage>90</epage><pages>81-90</pages><issn>0735-7907</issn><eissn>1532-4192</eissn><abstract>Abstract
Selected populations of cats that were naturally exposed to the feline leukemia virus (FeLV) were found to have humoral antibodies to a normal cell protein designated NCP105. Earlier studies revealed that cats exposed to FeLV often had serum antibodies to the feline oncornavirus-associated cell membrane (FOCMA) as well as to a feline sarcoma virus (FeSV)-specific transforming protein designated gag-fes. Cats with no history of exposure to FeLV or FeSV lacked antibodies to all three antigens: NCP105, FOCMA, and gag-fes. Following exposure to FeLV, cats develop antibodies to either NCP105 or to gag-fes and FOCMA, but not to both groups of antigens. NCP105 is present in both normal and transformed cells from a wide variety of species. It lacks peptide homology with gag-fes and it is not a phosphoprotein. The presence of antibodies to NCP105 in cats exposed to FeLV but not in unexposed cats suggests that FeLV may activate the NCP105 gene or increase the relative immunogenicity of this protein in vivo.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>6329486</pmid><doi>10.3109/07357908409020290</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0735-7907 |
| ispartof | Cancer investigation, 1984, Vol.2 (2), p.81-90 |
| issn | 0735-7907 1532-4192 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_81111843 |
| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Animals Antibodies, Viral - analysis Antibody Formation Antigens, Viral - immunology Cats Cell Transformation, Neoplastic feline leukemia virus Leukemia Virus, Feline - genetics Leukemia Virus, Feline - immunology Leukemia, Experimental - immunology Neoplasm Proteins - immunology Proteins - analysis Proteins - immunology |
| title | Infection with Feline Leukemia Virus Associated with Induction of Humoral Response to a Normal Cell Protein |
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