Myeloproliferative disorders terminating in acute megakaryoblastic leukemia with chromosome 3q26 abnormality
Two cases of myeloproliferative disorders terminating in acute megakaryoblastic leukemia are reported. One case began as primary myelofibrosis and the other as chronic myelogenous leukemia. Blast cells in the acute leukemic phase were identified as megakaryoblasts by the presence of platelet peroxid...
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| Veröffentlicht in: | Cancer 1987-12, Vol.60 (11), p.2654-2661 |
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| container_issue | 11 |
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| container_title | Cancer |
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| creator | Akahoshi, Masako Oshimi, Kazuo Mizoguchi, Hideaki Okada, Michiko Enomoto, Yasuhiro Watanabe, Younosuke |
| description | Two cases of myeloproliferative disorders terminating in acute megakaryoblastic leukemia are reported. One case began as primary myelofibrosis and the other as chronic myelogenous leukemia. Blast cells in the acute leukemic phase were identified as megakaryoblasts by the presence of platelet peroxidase. The clinical course is described, and the morphology, immunologic studies, and ultrastructure studies of the blast cells are reported. On cytogenetic analysis both cases had a translocation involving the No. 3 chromosome locus q26.2. The present data suggest that 3q26 may be associated with transformation of the megakaryocytic lineage. |
| doi_str_mv | 10.1002/1097-0142(19871201)60:11<2654::AID-CNCR2820601114>3.0.CO;2-Q |
| format | Article |
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One case began as primary myelofibrosis and the other as chronic myelogenous leukemia. Blast cells in the acute leukemic phase were identified as megakaryoblasts by the presence of platelet peroxidase. The clinical course is described, and the morphology, immunologic studies, and ultrastructure studies of the blast cells are reported. On cytogenetic analysis both cases had a translocation involving the No. 3 chromosome locus q26.2. The present data suggest that 3q26 may be associated with transformation of the megakaryocytic lineage.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/1097-0142(19871201)60:11<2654::AID-CNCR2820601114>3.0.CO;2-Q</identifier><identifier>PMID: 3479228</identifier><identifier>CODEN: CANCAR</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Biological and medical sciences ; Blood Platelets - enzymology ; Chromosomes, Human, Pair 3 ; Female ; Hematologic and hematopoietic diseases ; Humans ; Leukemia, Megakaryoblastic, Acute - genetics ; Leukemias. Malignant lymphomas. Malignant reticulosis. 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One case began as primary myelofibrosis and the other as chronic myelogenous leukemia. Blast cells in the acute leukemic phase were identified as megakaryoblasts by the presence of platelet peroxidase. The clinical course is described, and the morphology, immunologic studies, and ultrastructure studies of the blast cells are reported. On cytogenetic analysis both cases had a translocation involving the No. 3 chromosome locus q26.2. The present data suggest that 3q26 may be associated with transformation of the megakaryocytic lineage.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Blood Platelets - enzymology</subject><subject>Chromosomes, Human, Pair 3</subject><subject>Female</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Leukemia, Megakaryoblastic, Acute - genetics</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myeloproliferative Disorders - complications</subject><subject>Peroxidases - blood</subject><subject>Translocation, Genetic</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVUV2L1DAUDaKs4-pPEPIgog8d89W0nRVh6fqxsDqsKPgghNv2djZu2uwmHZf592aYcUAfBJ_CzTn3cO45hJxxNueMiVecVUXGuBIveFUWXDD-UrMF56-FztVicXp-ltWf6s-iFEwzzrl6I-dsXi9PRHZ5j8wO6_fJjDFWZrmS3x6SRzH-SGMhcnlEjqQqKiHKGXEfN-j8TfDO9hhgsj-Rdjb60GGIdMIw2DH9jitqRwrtekI64AquIWx84yBOtqUO19c4WKB3drqi7VXwg49-QCpvhabQjD4M4Oy0eUwe9OAiPtm_x-Tru7df6g_ZxfL9eX16kbV5Mp71Rd5I4JiDApZjqXsNUrVSgSp4V4peFBp7DlpB0-VCS4BGq05hJSoQWslj8nynm-66XWOczGBji87BiH4dTZlS41JWifh9R2yDjzFgb26CHdJthjOzLcNs0zTbNM3vMoxOEDfbMoxJZZg_yzDSMFMvjTCXSf7p3se6GbA7iO_TT_izPQ6xBdcHGFsbD7RCCV3oPNFWO9qddbj5T4v_dPgXIn8B-de2OA</recordid><startdate>19871201</startdate><enddate>19871201</enddate><creator>Akahoshi, Masako</creator><creator>Oshimi, Kazuo</creator><creator>Mizoguchi, Hideaki</creator><creator>Okada, Michiko</creator><creator>Enomoto, Yasuhiro</creator><creator>Watanabe, Younosuke</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19871201</creationdate><title>Myeloproliferative disorders terminating in acute megakaryoblastic leukemia with chromosome 3q26 abnormality</title><author>Akahoshi, Masako ; Oshimi, Kazuo ; Mizoguchi, Hideaki ; Okada, Michiko ; Enomoto, Yasuhiro ; Watanabe, Younosuke</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5014-f75b3a1e5a4a05e86f6a34c34a471d82f276ef1a64abd5263aab64d4e929a2643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Blood Platelets - enzymology</topic><topic>Chromosomes, Human, Pair 3</topic><topic>Female</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Leukemia, Megakaryoblastic, Acute - genetics</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myeloproliferative Disorders - complications</topic><topic>Peroxidases - blood</topic><topic>Translocation, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Akahoshi, Masako</creatorcontrib><creatorcontrib>Oshimi, Kazuo</creatorcontrib><creatorcontrib>Mizoguchi, Hideaki</creatorcontrib><creatorcontrib>Okada, Michiko</creatorcontrib><creatorcontrib>Enomoto, Yasuhiro</creatorcontrib><creatorcontrib>Watanabe, Younosuke</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akahoshi, Masako</au><au>Oshimi, Kazuo</au><au>Mizoguchi, Hideaki</au><au>Okada, Michiko</au><au>Enomoto, Yasuhiro</au><au>Watanabe, Younosuke</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Myeloproliferative disorders terminating in acute megakaryoblastic leukemia with chromosome 3q26 abnormality</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>1987-12-01</date><risdate>1987</risdate><volume>60</volume><issue>11</issue><spage>2654</spage><epage>2661</epage><pages>2654-2661</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><coden>CANCAR</coden><abstract>Two cases of myeloproliferative disorders terminating in acute megakaryoblastic leukemia are reported. One case began as primary myelofibrosis and the other as chronic myelogenous leukemia. Blast cells in the acute leukemic phase were identified as megakaryoblasts by the presence of platelet peroxidase. The clinical course is described, and the morphology, immunologic studies, and ultrastructure studies of the blast cells are reported. On cytogenetic analysis both cases had a translocation involving the No. 3 chromosome locus q26.2. The present data suggest that 3q26 may be associated with transformation of the megakaryocytic lineage.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>3479228</pmid><doi>10.1002/1097-0142(19871201)60:11<2654::AID-CNCR2820601114>3.0.CO;2-Q</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Cancer, 1987-12, Vol.60 (11), p.2654-2661 |
| issn | 0008-543X 1097-0142 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Biological and medical sciences Blood Platelets - enzymology Chromosomes, Human, Pair 3 Female Hematologic and hematopoietic diseases Humans Leukemia, Megakaryoblastic, Acute - genetics Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Middle Aged Myeloproliferative Disorders - complications Peroxidases - blood Translocation, Genetic |
| title | Myeloproliferative disorders terminating in acute megakaryoblastic leukemia with chromosome 3q26 abnormality |
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