β-ADRENOCEPTORS ON ENDOTHELIAL CELLS DO NOT INFLUENCE RELEASE OF RELAXING FACTOR IN DOG CORONARY ARTERIES

SUMMARY 1. The aim of this study was to determine if stimulation of a β‐adrenoceptor on endothelial cells could release an endothelium‐derived relaxing factor (EDRF) similar to that released by acetylcholine. 2. In dog coronary rings preconstricted with PGF2α or serotonin, removal of the endothelium...

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Veröffentlicht in:	Clinical and experimental pharmacology & physiology 1987-06, Vol.14 (6), p.525-534
Hauptverfasser:	Macdonald, Peter S., Dubbin, Philip N., Dusting, Gregory J.
Format:	Artikel
Sprache:	eng
Schlagworte:	15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid Acetylcholine - pharmacology Animals arteries Biological Products - metabolism Bradykinin - pharmacology canine coronary Coronary Vessels - drug effects Coronary Vessels - metabolism Dogs endothelium Endothelium, Vascular - physiology endothelium-derived relaxing factor (EDRF) Imidazoles - pharmacology In Vitro Techniques isoprenaline Isoproterenol - pharmacology Nitric Oxide Propanolamines - pharmacology Prostaglandin Endoperoxides, Synthetic - pharmacology Receptors, Adrenergic, beta - physiology Vasodilation - drug effects β-adrenoceptors
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