Neither nitroglycerin nor nitroprusside selectively reduces sepsis-induced pulmonary hypertension in piglets
No therapeutic agent consistently decreases pulmonary arterial pressure (PAP) more than aortic pressure in neonates with persistent pulmonary hypertension of the newborn. We have investigated whether nitroglycerin (NG) or nitroprusside (NP) selectively decreases PAP in an animal model of sepsis-indu...
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| Veröffentlicht in: | Critical care medicine 1987-12, Vol.15 (12), p.1127-1130 |
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| creator | RUDINSKY, BRIAN F KOMAR, KARL J STRATES, ELENE MEADOW, WILLIAM L |
| description | No therapeutic agent consistently decreases pulmonary arterial pressure (PAP) more than aortic pressure in neonates with persistent pulmonary hypertension of the newborn. We have investigated whether nitroglycerin (NG) or nitroprusside (NP) selectively decreases PAP in an animal model of sepsis-induced pulmonary hypertension. Piglets were anesthetized, intubated, and ventilated. Pulmonary hypertension was induced by an iv infusion of group B Streptococci. Piglets were then divided into three groups with group B Streptococci infusion ongoing. Neither PAP nor the pulmonary vascular resistance index was decreased significantly by either NP or NG. NP decreased significantly both mean aortic pressure and the systemic vascular resistance index. Cardiac index decreased significantly during both NG and placebo infusion. These data suggest that neither NP nor NG is likely to be beneficial in sepsis-induced pulmonary hypertension in newborns. |
| doi_str_mv | 10.1097/00003246-198712000-00010 |
| format | Article |
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We have investigated whether nitroglycerin (NG) or nitroprusside (NP) selectively decreases PAP in an animal model of sepsis-induced pulmonary hypertension. Piglets were anesthetized, intubated, and ventilated. Pulmonary hypertension was induced by an iv infusion of group B Streptococci. Piglets were then divided into three groups with group B Streptococci infusion ongoing. Neither PAP nor the pulmonary vascular resistance index was decreased significantly by either NP or NG. NP decreased significantly both mean aortic pressure and the systemic vascular resistance index. Cardiac index decreased significantly during both NG and placebo infusion. These data suggest that neither NP nor NG is likely to be beneficial in sepsis-induced pulmonary hypertension in newborns.</description><identifier>ISSN: 0090-3493</identifier><identifier>EISSN: 1530-0293</identifier><identifier>DOI: 10.1097/00003246-198712000-00010</identifier><identifier>PMID: 3119293</identifier><identifier>CODEN: CCMDC7</identifier><language>eng</language><publisher>Hagerstown, MD: Williams & Wilkins</publisher><subject>Animals ; Aorta - drug effects ; Aorta - physiopathology ; Biological and medical sciences ; Blood Pressure - drug effects ; Disease Models, Animal ; Drug Evaluation, Preclinical ; Ferricyanides - therapeutic use ; Humans ; Hypertension, Pulmonary - drug therapy ; Hypertension, Pulmonary - etiology ; Hypertension, Pulmonary - physiopathology ; Infant, Newborn ; Medical sciences ; Nitroglycerin - therapeutic use ; Nitroprusside - therapeutic use ; Persistent Fetal Circulation Syndrome - drug therapy ; Pharmacology. Drug treatments ; Pulmonary Artery - drug effects ; Pulmonary Artery - physiopathology ; Respiratory system ; Streptococcal Infections - complications ; Streptococcus agalactiae ; Swine ; Swine Diseases - drug therapy ; Swine Diseases - etiology ; Swine Diseases - physiopathology</subject><ispartof>Critical care medicine, 1987-12, Vol.15 (12), p.1127-1130</ispartof><rights>Williams & Wilkins 1987. All Rights Reserved.</rights><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3840-715234275346ff04d7b98b5dc1820d1e76040a7eab3816f7d7df08615bfe95e13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7521958$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3119293$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>RUDINSKY, BRIAN F</creatorcontrib><creatorcontrib>KOMAR, KARL J</creatorcontrib><creatorcontrib>STRATES, ELENE</creatorcontrib><creatorcontrib>MEADOW, WILLIAM L</creatorcontrib><title>Neither nitroglycerin nor nitroprusside selectively reduces sepsis-induced pulmonary hypertension in piglets</title><title>Critical care medicine</title><addtitle>Crit Care Med</addtitle><description>No therapeutic agent consistently decreases pulmonary arterial pressure (PAP) more than aortic pressure in neonates with persistent pulmonary hypertension of the newborn. We have investigated whether nitroglycerin (NG) or nitroprusside (NP) selectively decreases PAP in an animal model of sepsis-induced pulmonary hypertension. Piglets were anesthetized, intubated, and ventilated. Pulmonary hypertension was induced by an iv infusion of group B Streptococci. Piglets were then divided into three groups with group B Streptococci infusion ongoing. Neither PAP nor the pulmonary vascular resistance index was decreased significantly by either NP or NG. NP decreased significantly both mean aortic pressure and the systemic vascular resistance index. Cardiac index decreased significantly during both NG and placebo infusion. These data suggest that neither NP nor NG is likely to be beneficial in sepsis-induced pulmonary hypertension in newborns.</description><subject>Animals</subject><subject>Aorta - drug effects</subject><subject>Aorta - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Disease Models, Animal</subject><subject>Drug Evaluation, Preclinical</subject><subject>Ferricyanides - therapeutic use</subject><subject>Humans</subject><subject>Hypertension, Pulmonary - drug therapy</subject><subject>Hypertension, Pulmonary - etiology</subject><subject>Hypertension, Pulmonary - physiopathology</subject><subject>Infant, Newborn</subject><subject>Medical sciences</subject><subject>Nitroglycerin - therapeutic use</subject><subject>Nitroprusside - therapeutic use</subject><subject>Persistent Fetal Circulation Syndrome - drug therapy</subject><subject>Pharmacology. Drug treatments</subject><subject>Pulmonary Artery - drug effects</subject><subject>Pulmonary Artery - physiopathology</subject><subject>Respiratory system</subject><subject>Streptococcal Infections - complications</subject><subject>Streptococcus agalactiae</subject><subject>Swine</subject><subject>Swine Diseases - drug therapy</subject><subject>Swine Diseases - etiology</subject><subject>Swine Diseases - physiopathology</subject><issn>0090-3493</issn><issn>1530-0293</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU2PFCEQQInRrLOrP8GkD8ZbKzTQwNFs_Eo2etEzoaF6B2Xolup2M_9exumdmySEVNWrIjwIaRh9y6hR72hdvBN9y4xWrKtRWzejT8iOSV6DzvCnZEepoS0Xhj8n14g_KyGk4lfkijNmKrIj6SvEZQ-lyXEp0306eigxN3naMnNZEWOABiGBX-IfSMemQFg9YM3NGLGN-RSGZl7TYcquHJv9cYayQMY45aaOm-N9ggVfkGejSwgvt_OG_Pj44fvt5_bu26cvt-_vWs-1oK1isuOiU5KLfhypCGowepDBM93RwED1VFCnwA1cs35UQYWR6p7JYQQjgfEb8uY8dy7T7xVwsYeIHlJyGaYVrWZVouAnUJ9BXybEAqOdSzzUF1hG7Um0fRRtL6LtP9G19dV2xzocIFwaN7O1_nqrO_QujcVlH_GCKdkxI3XFxBl7mNICBX-l9QGK3YNLy97-75v5XwWcl1k</recordid><startdate>198712</startdate><enddate>198712</enddate><creator>RUDINSKY, BRIAN F</creator><creator>KOMAR, KARL J</creator><creator>STRATES, ELENE</creator><creator>MEADOW, WILLIAM L</creator><general>Williams & Wilkins</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198712</creationdate><title>Neither nitroglycerin nor nitroprusside selectively reduces sepsis-induced pulmonary hypertension in piglets</title><author>RUDINSKY, BRIAN F ; KOMAR, KARL J ; STRATES, ELENE ; MEADOW, WILLIAM L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3840-715234275346ff04d7b98b5dc1820d1e76040a7eab3816f7d7df08615bfe95e13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Animals</topic><topic>Aorta - drug effects</topic><topic>Aorta - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Disease Models, Animal</topic><topic>Drug Evaluation, Preclinical</topic><topic>Ferricyanides - therapeutic use</topic><topic>Humans</topic><topic>Hypertension, Pulmonary - drug therapy</topic><topic>Hypertension, Pulmonary - etiology</topic><topic>Hypertension, Pulmonary - physiopathology</topic><topic>Infant, Newborn</topic><topic>Medical sciences</topic><topic>Nitroglycerin - therapeutic use</topic><topic>Nitroprusside - therapeutic use</topic><topic>Persistent Fetal Circulation Syndrome - drug therapy</topic><topic>Pharmacology. Drug treatments</topic><topic>Pulmonary Artery - drug effects</topic><topic>Pulmonary Artery - physiopathology</topic><topic>Respiratory system</topic><topic>Streptococcal Infections - complications</topic><topic>Streptococcus agalactiae</topic><topic>Swine</topic><topic>Swine Diseases - drug therapy</topic><topic>Swine Diseases - etiology</topic><topic>Swine Diseases - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>RUDINSKY, BRIAN F</creatorcontrib><creatorcontrib>KOMAR, KARL J</creatorcontrib><creatorcontrib>STRATES, ELENE</creatorcontrib><creatorcontrib>MEADOW, WILLIAM L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Critical care medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>RUDINSKY, BRIAN F</au><au>KOMAR, KARL J</au><au>STRATES, ELENE</au><au>MEADOW, WILLIAM L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neither nitroglycerin nor nitroprusside selectively reduces sepsis-induced pulmonary hypertension in piglets</atitle><jtitle>Critical care medicine</jtitle><addtitle>Crit Care Med</addtitle><date>1987-12</date><risdate>1987</risdate><volume>15</volume><issue>12</issue><spage>1127</spage><epage>1130</epage><pages>1127-1130</pages><issn>0090-3493</issn><eissn>1530-0293</eissn><coden>CCMDC7</coden><abstract>No therapeutic agent consistently decreases pulmonary arterial pressure (PAP) more than aortic pressure in neonates with persistent pulmonary hypertension of the newborn. We have investigated whether nitroglycerin (NG) or nitroprusside (NP) selectively decreases PAP in an animal model of sepsis-induced pulmonary hypertension. Piglets were anesthetized, intubated, and ventilated. Pulmonary hypertension was induced by an iv infusion of group B Streptococci. Piglets were then divided into three groups with group B Streptococci infusion ongoing. Neither PAP nor the pulmonary vascular resistance index was decreased significantly by either NP or NG. NP decreased significantly both mean aortic pressure and the systemic vascular resistance index. Cardiac index decreased significantly during both NG and placebo infusion. These data suggest that neither NP nor NG is likely to be beneficial in sepsis-induced pulmonary hypertension in newborns.</abstract><cop>Hagerstown, MD</cop><pub>Williams & Wilkins</pub><pmid>3119293</pmid><doi>10.1097/00003246-198712000-00010</doi><tpages>4</tpages></addata></record> |
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| issn | 0090-3493 1530-0293 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Animals Aorta - drug effects Aorta - physiopathology Biological and medical sciences Blood Pressure - drug effects Disease Models, Animal Drug Evaluation, Preclinical Ferricyanides - therapeutic use Humans Hypertension, Pulmonary - drug therapy Hypertension, Pulmonary - etiology Hypertension, Pulmonary - physiopathology Infant, Newborn Medical sciences Nitroglycerin - therapeutic use Nitroprusside - therapeutic use Persistent Fetal Circulation Syndrome - drug therapy Pharmacology. Drug treatments Pulmonary Artery - drug effects Pulmonary Artery - physiopathology Respiratory system Streptococcal Infections - complications Streptococcus agalactiae Swine Swine Diseases - drug therapy Swine Diseases - etiology Swine Diseases - physiopathology |
| title | Neither nitroglycerin nor nitroprusside selectively reduces sepsis-induced pulmonary hypertension in piglets |
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