The scavenging of oxidants by sulphasalazine and its metabolites: A possible contribution to their anti-inflammatory effects?
Sulphasalazine (Salazopyrin) and its metabolites sulphapyridine and 5-aminosalicylate are powerful scavengers of the hydroxyl radical, determined by pulse radiolysis and confirmed by assays based on deoxyribose degradation by hydroxyl radicals. 5-Aminosalicylate can also protect α 1-anti-protease ag...
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| Veröffentlicht in: | Biochemical pharmacology 1987-11, Vol.36 (21), p.3739-3742 |
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| container_end_page | 3742 |
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| container_issue | 21 |
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| container_title | Biochemical pharmacology |
| container_volume | 36 |
| creator | Aruoma, Okezie I. Wasil, Mohammad Halliwell, Barry Hoey, Brigid M. Butler, John |
| description | Sulphasalazine (Salazopyrin) and its metabolites sulphapyridine and 5-aminosalicylate are powerful scavengers of the hydroxyl radical, determined by pulse radiolysis and confirmed by assays based on deoxyribose degradation by hydroxyl radicals. 5-Aminosalicylate can also protect α
1-anti-protease against attack by the myeloperoxidase-derived oxidant hypochlorous acid. The ability to scavenge oxidants produced at sites of inflammation may contribute to the anti-inflammatory action of sulphasalazine and its metabolites. |
| doi_str_mv | 10.1016/0006-2952(87)90028-1 |
| format | Article |
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| fulltext | fulltext |
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| ispartof | Biochemical pharmacology, 1987-11, Vol.36 (21), p.3739-3742 |
| issn | 0006-2952 1873-2968 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Aminosalicylic Acids - pharmacology Anti-Inflammatory Agents - pharmacology Hydroxides Hydroxyl Radical Hypochlorous Acid - pharmacology Mesalamine Oxidation-Reduction Sulfanilamides - pharmacology Sulfapyridine - pharmacology Sulfasalazine - pharmacology |
| title | The scavenging of oxidants by sulphasalazine and its metabolites: A possible contribution to their anti-inflammatory effects? |
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