Effects of smoking on fetoplacental-maternal system during pregnancy
Fetoplacental function and maternal nutritional condition were assessed in order to clarify the mechanism of retarded fetal growth in pregnant women who smoked. Dehydroepiandrosterone sulfate (DHA-S) loading tests and measurements of cotinine, which is a major metabolite of nicotine, were also made....
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| Veröffentlicht in: | American journal of obstetrics and gynecology 1984-06, Vol.149 (4), p.413-420 |
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| container_end_page | 420 |
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| container_issue | 4 |
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| container_title | American journal of obstetrics and gynecology |
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| creator | Mochizuki, Matsuto Maruo, Takeshi Masuko, Kazuhisa Ohtsu, Toshihiko |
| description | Fetoplacental function and maternal nutritional condition were assessed in order to clarify the mechanism of retarded fetal growth in pregnant women who smoked. Dehydroepiandrosterone sulfate (DHA-S) loading tests and measurements of cotinine, which is a major metabolite of nicotine, were also made. In heavy smokers, urinary estriol and serum levels of human placental lactogen (hPL) were lower than those in nonsmokers. There was no difference in maternal nutrition between smokers and nonsmokers. Heavy smokers demonstrated a lower conversion of DHA-S to estradiol than did nonsmokers. Levels of cotinine in maternal blood and umbilical cord blood of heavy smokers were remarkably higher than those in nonsmokers. Microscopic examination showed atrophic and hypovascular changes in placental villi from mothers who smoked. These results suggest that retarded fetal growth in heavy smokers is due to impairment of uteroplacental circulation as a result of the vasoconstricting effect of nicotine. |
| doi_str_mv | 10.1016/0002-9378(84)90156-X |
| format | Article |
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Dehydroepiandrosterone sulfate (DHA-S) loading tests and measurements of cotinine, which is a major metabolite of nicotine, were also made. In heavy smokers, urinary estriol and serum levels of human placental lactogen (hPL) were lower than those in nonsmokers. There was no difference in maternal nutrition between smokers and nonsmokers. Heavy smokers demonstrated a lower conversion of DHA-S to estradiol than did nonsmokers. Levels of cotinine in maternal blood and umbilical cord blood of heavy smokers were remarkably higher than those in nonsmokers. Microscopic examination showed atrophic and hypovascular changes in placental villi from mothers who smoked. 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Dehydroepiandrosterone sulfate (DHA-S) loading tests and measurements of cotinine, which is a major metabolite of nicotine, were also made. In heavy smokers, urinary estriol and serum levels of human placental lactogen (hPL) were lower than those in nonsmokers. There was no difference in maternal nutrition between smokers and nonsmokers. Heavy smokers demonstrated a lower conversion of DHA-S to estradiol than did nonsmokers. Levels of cotinine in maternal blood and umbilical cord blood of heavy smokers were remarkably higher than those in nonsmokers. Microscopic examination showed atrophic and hypovascular changes in placental villi from mothers who smoked. These results suggest that retarded fetal growth in heavy smokers is due to impairment of uteroplacental circulation as a result of the vasoconstricting effect of nicotine.</description><subject>alpha-Fetoproteins - blood</subject><subject>Biological and medical sciences</subject><subject>Birth Weight</subject><subject>Blood Glucose</subject><subject>Chorionic Villi - drug effects</subject><subject>Chorionic Villi - pathology</subject><subject>Copper - blood</subject><subject>Cotinine - blood</subject><subject>Cotinine - urine</subject><subject>Dehydroepiandrosterone - metabolism</subject><subject>Estriol - urine</subject><subject>Female</subject><subject>Fetal Blood - analysis</subject><subject>Fetus - drug effects</subject><subject>Fetus - physiology</subject><subject>Growth</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>L-Lactate Dehydrogenase - blood</subject><subject>Medical sciences</subject><subject>Nicotine - pharmacology</subject><subject>Placental Lactogen - blood</subject><subject>Population</subject><subject>Pregnancy</subject><subject>Smoking</subject><subject>Tobacco, tobacco smoking</subject><subject>Toxemia - metabolism</subject><subject>Toxicology</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1r20AQhpfS4Dhp_0ELOpSSHNTOSKv9uASK4yQFQy8t-LasVrNGjT6cXTngfx8pNj4mp2GY5x2GZxj7gvADAcVPAMhSnUt1pfi1BixEuv7A5ghapkIJ9ZHNT8g5u4jx_9RmOpuxmcgg56Dm7HbpPbkhJr1PYts_1t0m6bvE09BvG-uoG2yTtnag0Nkmifs4UJtUuzBx20CbznZu_4mdedtE-nysl-zf3fLv4iFd_bn_vfi1Sh1HOaQVCVsAOpBekpV5ZW1eAiIKmflMIFdcFU6DpQKrHCuvS7RFKaDk6KTT-SX7fti7Df3TjuJg2jo6ahrbUb-LRiFCoWT-Log8UwAKRpAfQBf6GAN5sw11a8PeIJjJspmcmUmhUdy8WjbrMfb1uH9XtlSdQket4_zbcW6js40Po6U6njCltcz4dObNAaNR2nNNwURXU-eoqsP4FFP19dt3vAA8xJhK</recordid><startdate>19840615</startdate><enddate>19840615</enddate><creator>Mochizuki, Matsuto</creator><creator>Maruo, Takeshi</creator><creator>Masuko, Kazuhisa</creator><creator>Ohtsu, Toshihiko</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>19840615</creationdate><title>Effects of smoking on fetoplacental-maternal system during pregnancy</title><author>Mochizuki, Matsuto ; Maruo, Takeshi ; Masuko, Kazuhisa ; Ohtsu, Toshihiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-de6a501c07f7ea73daa3b0111672f26148485c90ae51d31df9b1a5b60b41c7c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>alpha-Fetoproteins - blood</topic><topic>Biological and medical sciences</topic><topic>Birth Weight</topic><topic>Blood Glucose</topic><topic>Chorionic Villi - drug effects</topic><topic>Chorionic Villi - pathology</topic><topic>Copper - blood</topic><topic>Cotinine - blood</topic><topic>Cotinine - urine</topic><topic>Dehydroepiandrosterone - metabolism</topic><topic>Estriol - urine</topic><topic>Female</topic><topic>Fetal Blood - analysis</topic><topic>Fetus - drug effects</topic><topic>Fetus - physiology</topic><topic>Growth</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>L-Lactate Dehydrogenase - blood</topic><topic>Medical sciences</topic><topic>Nicotine - pharmacology</topic><topic>Placental Lactogen - blood</topic><topic>Population</topic><topic>Pregnancy</topic><topic>Smoking</topic><topic>Tobacco, tobacco smoking</topic><topic>Toxemia - metabolism</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mochizuki, Matsuto</creatorcontrib><creatorcontrib>Maruo, Takeshi</creatorcontrib><creatorcontrib>Masuko, Kazuhisa</creatorcontrib><creatorcontrib>Ohtsu, Toshihiko</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mochizuki, Matsuto</au><au>Maruo, Takeshi</au><au>Masuko, Kazuhisa</au><au>Ohtsu, Toshihiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of smoking on fetoplacental-maternal system during pregnancy</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>1984-06-15</date><risdate>1984</risdate><volume>149</volume><issue>4</issue><spage>413</spage><epage>420</epage><pages>413-420</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><coden>AJOGAH</coden><abstract>Fetoplacental function and maternal nutritional condition were assessed in order to clarify the mechanism of retarded fetal growth in pregnant women who smoked. Dehydroepiandrosterone sulfate (DHA-S) loading tests and measurements of cotinine, which is a major metabolite of nicotine, were also made. In heavy smokers, urinary estriol and serum levels of human placental lactogen (hPL) were lower than those in nonsmokers. There was no difference in maternal nutrition between smokers and nonsmokers. Heavy smokers demonstrated a lower conversion of DHA-S to estradiol than did nonsmokers. Levels of cotinine in maternal blood and umbilical cord blood of heavy smokers were remarkably higher than those in nonsmokers. Microscopic examination showed atrophic and hypovascular changes in placental villi from mothers who smoked. These results suggest that retarded fetal growth in heavy smokers is due to impairment of uteroplacental circulation as a result of the vasoconstricting effect of nicotine.</abstract><cop>Philadelphia, PA</cop><pub>Elsevier Inc</pub><pmid>6203408</pmid><doi>10.1016/0002-9378(84)90156-X</doi><tpages>8</tpages></addata></record> |
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| ispartof | American journal of obstetrics and gynecology, 1984-06, Vol.149 (4), p.413-420 |
| issn | 0002-9378 1097-6868 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | alpha-Fetoproteins - blood Biological and medical sciences Birth Weight Blood Glucose Chorionic Villi - drug effects Chorionic Villi - pathology Copper - blood Cotinine - blood Cotinine - urine Dehydroepiandrosterone - metabolism Estriol - urine Female Fetal Blood - analysis Fetus - drug effects Fetus - physiology Growth Humans Infant, Newborn L-Lactate Dehydrogenase - blood Medical sciences Nicotine - pharmacology Placental Lactogen - blood Population Pregnancy Smoking Tobacco, tobacco smoking Toxemia - metabolism Toxicology |
| title | Effects of smoking on fetoplacental-maternal system during pregnancy |
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