Prognostic significance of histologic classification and grading of epithelial malignancies of the ovary
Overall survival in 1938 women with epithelial ovarian cancer receiving primary treatment at Mayo Clinic was 35% at 5 years, 28% at 10 years, and 15% at 25 years. For most histologic cell types, observed differences in survival were more apparent than real since the behavior of different cell types...
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| Veröffentlicht in: | American journal of obstetrics and gynecology 1984-06, Vol.149 (3), p.274-284 |
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| container_title | American journal of obstetrics and gynecology |
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| creator | Malkasian, George D. Melton, L.Joseph O'Brien, Peter C. Greene, Mark H. |
| description | Overall survival in 1938 women with epithelial ovarian cancer receiving primary treatment at Mayo Clinic was 35% at 5 years, 28% at 10 years, and 15% at 25 years. For most histologic cell types, observed differences in survival were more apparent than real since the behavior of different cell types was similar when compared stage for stage and grade for grade. Mucinous cystadenocarcinomas tended to be low grade and low stage, while serous cystadenocarcinomas tended to be high grade and high stage. For Stage I disease, factors other than cell type seemed to be more important in determining survival; specifically. Stage IA1 patients did significantly better than all other Stage I patients. In Stage III disease, the amount of residual tumor made a significant difference in survival for all grades. In Stage IV disease, the amount of residual made a highly significant difference in survival for grade 1 disease. |
| doi_str_mv | 10.1016/0002-9378(84)90227-8 |
| format | Article |
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For most histologic cell types, observed differences in survival were more apparent than real since the behavior of different cell types was similar when compared stage for stage and grade for grade. Mucinous cystadenocarcinomas tended to be low grade and low stage, while serous cystadenocarcinomas tended to be high grade and high stage. For Stage I disease, factors other than cell type seemed to be more important in determining survival; specifically. Stage IA1 patients did significantly better than all other Stage I patients. In Stage III disease, the amount of residual tumor made a significant difference in survival for all grades. 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Obstetrics ; Humans ; Medical sciences ; Mesonephroma - mortality ; Mesonephroma - pathology ; Neoplasm Staging ; Ovarian Neoplasms - classification ; Ovarian Neoplasms - mortality ; Ovarian Neoplasms - pathology ; Prognosis ; Tumors</subject><ispartof>American journal of obstetrics and gynecology, 1984-06, Vol.149 (3), p.274-284</ispartof><rights>1984</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-c15f5a3b7721c2a2ee88567caf53f6f9a09edee2913238046cbc78ae0f3143003</citedby><cites>FETCH-LOGICAL-c452t-c15f5a3b7721c2a2ee88567caf53f6f9a09edee2913238046cbc78ae0f3143003</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0002-9378(84)90227-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8992512$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6328995$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Malkasian, George D.</creatorcontrib><creatorcontrib>Melton, L.Joseph</creatorcontrib><creatorcontrib>O'Brien, Peter C.</creatorcontrib><creatorcontrib>Greene, Mark H.</creatorcontrib><title>Prognostic significance of histologic classification and grading of epithelial malignancies of the ovary</title><title>American journal of obstetrics and gynecology</title><addtitle>Am J Obstet Gynecol</addtitle><description>Overall survival in 1938 women with epithelial ovarian cancer receiving primary treatment at Mayo Clinic was 35% at 5 years, 28% at 10 years, and 15% at 25 years. For most histologic cell types, observed differences in survival were more apparent than real since the behavior of different cell types was similar when compared stage for stage and grade for grade. Mucinous cystadenocarcinomas tended to be low grade and low stage, while serous cystadenocarcinomas tended to be high grade and high stage. For Stage I disease, factors other than cell type seemed to be more important in determining survival; specifically. Stage IA1 patients did significantly better than all other Stage I patients. In Stage III disease, the amount of residual tumor made a significant difference in survival for all grades. In Stage IV disease, the amount of residual made a highly significant difference in survival for grade 1 disease.</description><subject>Adenocarcinoma - mortality</subject><subject>Adenocarcinoma - pathology</subject><subject>Adenocarcinoma, Mucinous - mortality</subject><subject>Adenocarcinoma, Mucinous - pathology</subject><subject>Age Factors</subject><subject>Biological and medical sciences</subject><subject>Carcinoma - mortality</subject><subject>Carcinoma - pathology</subject><subject>Cystadenocarcinoma - mortality</subject><subject>Cystadenocarcinoma - pathology</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Mesonephroma - mortality</subject><subject>Mesonephroma - pathology</subject><subject>Neoplasm Staging</subject><subject>Ovarian Neoplasms - classification</subject><subject>Ovarian Neoplasms - mortality</subject><subject>Ovarian Neoplasms - pathology</subject><subject>Prognosis</subject><subject>Tumors</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtrGzEURkVJcRy3_yCBWZSSLibRYx7SJlBCX2BIFulayJqrsYI8cnXHhvz7amzjZVbi6jv343IIuWb0jlHW3FNKealEK29l9U1RzttSfiBzRlVbNrKRF2R-Ri7JFeLrNHLFZ2TWCC6Vqudk_ZxiP0QcvS3Q94N33prBQhFdsfY4xhD7HNlgEA_Z6ONQmKEr-mQ6P_QTCFs_riF4E4qNCbklN3jAKcr_Rdyb9PaJfHQmIHw-vQvy9-ePl8ff5fLp15_H78vSVjUfS8tqVxuxalvOLDccQMq6aa1xtXCNU4Yq6AC4YoILSavGrmwrDVAnWCUoFQvy9di7TfHfDnDUG48WQjADxB1qyRit27y-INURtCkiJnB6m_wmX6oZ1ZNgPenSkz0tK30QrGVeuzn171Yb6M5LJ6M5_3LKDVoTXJpc4BnLDK8Zz9jDEYPsYu8haczKsvjOJ7Cj7qJ__47_06iYbg</recordid><startdate>19840601</startdate><enddate>19840601</enddate><creator>Malkasian, George D.</creator><creator>Melton, L.Joseph</creator><creator>O'Brien, Peter C.</creator><creator>Greene, Mark H.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19840601</creationdate><title>Prognostic significance of histologic classification and grading of epithelial malignancies of the ovary</title><author>Malkasian, George D. ; Melton, L.Joseph ; O'Brien, Peter C. ; Greene, Mark H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-c15f5a3b7721c2a2ee88567caf53f6f9a09edee2913238046cbc78ae0f3143003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Adenocarcinoma - mortality</topic><topic>Adenocarcinoma - pathology</topic><topic>Adenocarcinoma, Mucinous - mortality</topic><topic>Adenocarcinoma, Mucinous - pathology</topic><topic>Age Factors</topic><topic>Biological and medical sciences</topic><topic>Carcinoma - mortality</topic><topic>Carcinoma - pathology</topic><topic>Cystadenocarcinoma - mortality</topic><topic>Cystadenocarcinoma - pathology</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Mesonephroma - mortality</topic><topic>Mesonephroma - pathology</topic><topic>Neoplasm Staging</topic><topic>Ovarian Neoplasms - classification</topic><topic>Ovarian Neoplasms - mortality</topic><topic>Ovarian Neoplasms - pathology</topic><topic>Prognosis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Malkasian, George D.</creatorcontrib><creatorcontrib>Melton, L.Joseph</creatorcontrib><creatorcontrib>O'Brien, Peter C.</creatorcontrib><creatorcontrib>Greene, Mark H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Malkasian, George D.</au><au>Melton, L.Joseph</au><au>O'Brien, Peter C.</au><au>Greene, Mark H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic significance of histologic classification and grading of epithelial malignancies of the ovary</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>1984-06-01</date><risdate>1984</risdate><volume>149</volume><issue>3</issue><spage>274</spage><epage>284</epage><pages>274-284</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><coden>AJOGAH</coden><abstract>Overall survival in 1938 women with epithelial ovarian cancer receiving primary treatment at Mayo Clinic was 35% at 5 years, 28% at 10 years, and 15% at 25 years. For most histologic cell types, observed differences in survival were more apparent than real since the behavior of different cell types was similar when compared stage for stage and grade for grade. Mucinous cystadenocarcinomas tended to be low grade and low stage, while serous cystadenocarcinomas tended to be high grade and high stage. For Stage I disease, factors other than cell type seemed to be more important in determining survival; specifically. Stage IA1 patients did significantly better than all other Stage I patients. In Stage III disease, the amount of residual tumor made a significant difference in survival for all grades. In Stage IV disease, the amount of residual made a highly significant difference in survival for grade 1 disease.</abstract><cop>Philadelphia, PA</cop><pub>Elsevier Inc</pub><pmid>6328995</pmid><doi>10.1016/0002-9378(84)90227-8</doi><tpages>11</tpages></addata></record> |
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| ispartof | American journal of obstetrics and gynecology, 1984-06, Vol.149 (3), p.274-284 |
| issn | 0002-9378 1097-6868 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adenocarcinoma - mortality Adenocarcinoma - pathology Adenocarcinoma, Mucinous - mortality Adenocarcinoma, Mucinous - pathology Age Factors Biological and medical sciences Carcinoma - mortality Carcinoma - pathology Cystadenocarcinoma - mortality Cystadenocarcinoma - pathology Female Female genital diseases Gynecology. Andrology. Obstetrics Humans Medical sciences Mesonephroma - mortality Mesonephroma - pathology Neoplasm Staging Ovarian Neoplasms - classification Ovarian Neoplasms - mortality Ovarian Neoplasms - pathology Prognosis Tumors |
| title | Prognostic significance of histologic classification and grading of epithelial malignancies of the ovary |
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