In vitro metabolism of chlorpheniramine in the rabbit

The in vitro metabolism of 3-( p-chloiophenyl)-3-(2-pyridyl)- N, N-dimethylpropylamine (chlorpheniramine, I) by rabbit liver microsomes was examined. The metabolites, tentatively identified by gas-liquid chromatography-mass spectrometry, included the mono- and didemethyl metabolites, the aldehyde th...

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Veröffentlicht in:	Biochemical pharmacology 1987-10, Vol.36 (20), p.3445-3452
Hauptverfasser:	Kammerer, R.Craig, Lampe, Marilyn A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acylation Animals Biological and medical sciences Chlorpheniramine - metabolism Gas Chromatography-Mass Spectrometry Histamine and antagonists. Allergy In Vitro Techniques Male Medical sciences Microsomes, Liver - metabolism Pharmacology. Drug treatments Proadifen - pharmacology Rabbits
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