Presence of functional receptors for atrial natriuretic peptide in human pheochromocytoma
Pheochromocytoma, a catecholamine-secreting adrenomedullary tumor, has been shown to contain the functional receptor for human atrial natriuretic peptide(h-ANP). Release of catecholamines from tissue slices of pheochromocytoma was inhibited by h-ANP in a dose-dependent manner. Binding assays using 1...
Gespeichert in:
| Veröffentlicht in: | Biochemical and biophysical research communications 1987-10, Vol.148 (1), p.286-291 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 291 |
|---|---|
| container_issue | 1 |
| container_start_page | 286 |
| container_title | Biochemical and biophysical research communications |
| container_volume | 148 |
| creator | Shionoiri, H. Hirawa, N. Takasaki, I. Ishikawa, Y. Minamisawa, K. Miyajima, E. Kinoshita, Y. Shimoyama, K. Shimonaka, M. Ishido, M. Hirose, S. |
| description | Pheochromocytoma, a catecholamine-secreting adrenomedullary tumor, has been shown to contain the functional receptor for human atrial natriuretic peptide(h-ANP). Release of catecholamines from tissue slices of pheochromocytoma was inhibited by h-ANP in a dose-dependent manner. Binding assays using
125I-ANP revealed a single class of high affinity binding sites for ANP. When covalently tagged with
125I-ANP and electrophoresed under non-reducing and reducing conditions, the receptor migrated as a 140-kDa band and a 70-kDa band, respectively, reflecting its disulfide-linked subunit structure. The presence of ANP receptor in pheochromocytoma was further demonstrated by immuno-histochemistry; the tumor was positively stained with an anti-receptor antiserum. The antiserum was also useful to establish the zona glomerulosa localization of ANP receptor in the normal human adrenal gland. |
| doi_str_mv | 10.1016/0006-291X(87)91108-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_81103925</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0006291X87911089</els_id><sourcerecordid>14864846</sourcerecordid><originalsourceid>FETCH-LOGICAL-c417t-ea2c661220e0617c7c48b3886bc7bb7ed0aaa0c785666761e3eeab468655cba33</originalsourceid><addsrcrecordid>eNqFkUGL1TAQx4Mo69vVb6CQg8h66Dpp0yS9LMii7sLCelDQU0inU16kbWrSCvvtTX2Pd9TTwPx_Mwy_YeyVgCsBQr0HAFWUjfh-afS7RggwRfOE7QQ0UJQC5FO2OyHP2XlKPwGEkKo5Y2elKSsD9Y79-BIp0YTEQ8_7dcLFh8kNPBLSvISYeB8id0v0uTltdY20eORzjn1H3E98v45u4vOeAu5jGAM-LmF0L9iz3g2JXh7rBfv26ePXm9vi_uHz3c2H-wKl0EtBrkSlRFkCgRIaNUrTVsaoFnXbaurAOQeoTa2U0kpQReRaqYyqa2xdVV2wt4e9cwy_VkqLHX1CGgY3UViTNdlM1ZT1f0EhjZJGqgzKA4gxpBSpt3P0o4uPVoDd1NvNq928WqPtX_W2yWOvj_vXdqTuNHR0nfM3x9wldEMf3YQ-nTBtpJYAGbs-YJSl_fYUbUK_fajz-SmL7YL_9x1_AJZLoPE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>14864846</pqid></control><display><type>article</type><title>Presence of functional receptors for atrial natriuretic peptide in human pheochromocytoma</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Shionoiri, H. ; Hirawa, N. ; Takasaki, I. ; Ishikawa, Y. ; Minamisawa, K. ; Miyajima, E. ; Kinoshita, Y. ; Shimoyama, K. ; Shimonaka, M. ; Ishido, M. ; Hirose, S.</creator><creatorcontrib>Shionoiri, H. ; Hirawa, N. ; Takasaki, I. ; Ishikawa, Y. ; Minamisawa, K. ; Miyajima, E. ; Kinoshita, Y. ; Shimoyama, K. ; Shimonaka, M. ; Ishido, M. ; Hirose, S.</creatorcontrib><description>Pheochromocytoma, a catecholamine-secreting adrenomedullary tumor, has been shown to contain the functional receptor for human atrial natriuretic peptide(h-ANP). Release of catecholamines from tissue slices of pheochromocytoma was inhibited by h-ANP in a dose-dependent manner. Binding assays using
125I-ANP revealed a single class of high affinity binding sites for ANP. When covalently tagged with
125I-ANP and electrophoresed under non-reducing and reducing conditions, the receptor migrated as a 140-kDa band and a 70-kDa band, respectively, reflecting its disulfide-linked subunit structure. The presence of ANP receptor in pheochromocytoma was further demonstrated by immuno-histochemistry; the tumor was positively stained with an anti-receptor antiserum. The antiserum was also useful to establish the zona glomerulosa localization of ANP receptor in the normal human adrenal gland.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/0006-291X(87)91108-9</identifier><identifier>PMID: 2823805</identifier><identifier>CODEN: BBRCA9</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Adrenal Gland Neoplasms - metabolism ; Adrenal Gland Neoplasms - pathology ; Applied sciences ; Atrial Natriuretic Factor - metabolism ; Atrial Natriuretic Factor - pharmacology ; atrial natriuretic hormone ; Epinephrine - metabolism ; Exact sciences and technology ; Humans ; In Vitro Techniques ; Kinetics ; man ; Norepinephrine - metabolism ; Other techniques and industries ; Pheochromocytoma - metabolism ; Pheochromocytoma - pathology ; pheochromocytoma cells ; Receptors, Atrial Natriuretic Factor ; Receptors, Cell Surface - metabolism</subject><ispartof>Biochemical and biophysical research communications, 1987-10, Vol.148 (1), p.286-291</ispartof><rights>1987</rights><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-ea2c661220e0617c7c48b3886bc7bb7ed0aaa0c785666761e3eeab468655cba33</citedby><cites>FETCH-LOGICAL-c417t-ea2c661220e0617c7c48b3886bc7bb7ed0aaa0c785666761e3eeab468655cba33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-291X(87)91108-9$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7847400$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2823805$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shionoiri, H.</creatorcontrib><creatorcontrib>Hirawa, N.</creatorcontrib><creatorcontrib>Takasaki, I.</creatorcontrib><creatorcontrib>Ishikawa, Y.</creatorcontrib><creatorcontrib>Minamisawa, K.</creatorcontrib><creatorcontrib>Miyajima, E.</creatorcontrib><creatorcontrib>Kinoshita, Y.</creatorcontrib><creatorcontrib>Shimoyama, K.</creatorcontrib><creatorcontrib>Shimonaka, M.</creatorcontrib><creatorcontrib>Ishido, M.</creatorcontrib><creatorcontrib>Hirose, S.</creatorcontrib><title>Presence of functional receptors for atrial natriuretic peptide in human pheochromocytoma</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>Pheochromocytoma, a catecholamine-secreting adrenomedullary tumor, has been shown to contain the functional receptor for human atrial natriuretic peptide(h-ANP). Release of catecholamines from tissue slices of pheochromocytoma was inhibited by h-ANP in a dose-dependent manner. Binding assays using
125I-ANP revealed a single class of high affinity binding sites for ANP. When covalently tagged with
125I-ANP and electrophoresed under non-reducing and reducing conditions, the receptor migrated as a 140-kDa band and a 70-kDa band, respectively, reflecting its disulfide-linked subunit structure. The presence of ANP receptor in pheochromocytoma was further demonstrated by immuno-histochemistry; the tumor was positively stained with an anti-receptor antiserum. The antiserum was also useful to establish the zona glomerulosa localization of ANP receptor in the normal human adrenal gland.</description><subject>Adrenal Gland Neoplasms - metabolism</subject><subject>Adrenal Gland Neoplasms - pathology</subject><subject>Applied sciences</subject><subject>Atrial Natriuretic Factor - metabolism</subject><subject>Atrial Natriuretic Factor - pharmacology</subject><subject>atrial natriuretic hormone</subject><subject>Epinephrine - metabolism</subject><subject>Exact sciences and technology</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Kinetics</subject><subject>man</subject><subject>Norepinephrine - metabolism</subject><subject>Other techniques and industries</subject><subject>Pheochromocytoma - metabolism</subject><subject>Pheochromocytoma - pathology</subject><subject>pheochromocytoma cells</subject><subject>Receptors, Atrial Natriuretic Factor</subject><subject>Receptors, Cell Surface - metabolism</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUGL1TAQx4Mo69vVb6CQg8h66Dpp0yS9LMii7sLCelDQU0inU16kbWrSCvvtTX2Pd9TTwPx_Mwy_YeyVgCsBQr0HAFWUjfh-afS7RggwRfOE7QQ0UJQC5FO2OyHP2XlKPwGEkKo5Y2elKSsD9Y79-BIp0YTEQ8_7dcLFh8kNPBLSvISYeB8id0v0uTltdY20eORzjn1H3E98v45u4vOeAu5jGAM-LmF0L9iz3g2JXh7rBfv26ePXm9vi_uHz3c2H-wKl0EtBrkSlRFkCgRIaNUrTVsaoFnXbaurAOQeoTa2U0kpQReRaqYyqa2xdVV2wt4e9cwy_VkqLHX1CGgY3UViTNdlM1ZT1f0EhjZJGqgzKA4gxpBSpt3P0o4uPVoDd1NvNq928WqPtX_W2yWOvj_vXdqTuNHR0nfM3x9wldEMf3YQ-nTBtpJYAGbs-YJSl_fYUbUK_fajz-SmL7YL_9x1_AJZLoPE</recordid><startdate>19871014</startdate><enddate>19871014</enddate><creator>Shionoiri, H.</creator><creator>Hirawa, N.</creator><creator>Takasaki, I.</creator><creator>Ishikawa, Y.</creator><creator>Minamisawa, K.</creator><creator>Miyajima, E.</creator><creator>Kinoshita, Y.</creator><creator>Shimoyama, K.</creator><creator>Shimonaka, M.</creator><creator>Ishido, M.</creator><creator>Hirose, S.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19871014</creationdate><title>Presence of functional receptors for atrial natriuretic peptide in human pheochromocytoma</title><author>Shionoiri, H. ; Hirawa, N. ; Takasaki, I. ; Ishikawa, Y. ; Minamisawa, K. ; Miyajima, E. ; Kinoshita, Y. ; Shimoyama, K. ; Shimonaka, M. ; Ishido, M. ; Hirose, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-ea2c661220e0617c7c48b3886bc7bb7ed0aaa0c785666761e3eeab468655cba33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Adrenal Gland Neoplasms - metabolism</topic><topic>Adrenal Gland Neoplasms - pathology</topic><topic>Applied sciences</topic><topic>Atrial Natriuretic Factor - metabolism</topic><topic>Atrial Natriuretic Factor - pharmacology</topic><topic>atrial natriuretic hormone</topic><topic>Epinephrine - metabolism</topic><topic>Exact sciences and technology</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Kinetics</topic><topic>man</topic><topic>Norepinephrine - metabolism</topic><topic>Other techniques and industries</topic><topic>Pheochromocytoma - metabolism</topic><topic>Pheochromocytoma - pathology</topic><topic>pheochromocytoma cells</topic><topic>Receptors, Atrial Natriuretic Factor</topic><topic>Receptors, Cell Surface - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shionoiri, H.</creatorcontrib><creatorcontrib>Hirawa, N.</creatorcontrib><creatorcontrib>Takasaki, I.</creatorcontrib><creatorcontrib>Ishikawa, Y.</creatorcontrib><creatorcontrib>Minamisawa, K.</creatorcontrib><creatorcontrib>Miyajima, E.</creatorcontrib><creatorcontrib>Kinoshita, Y.</creatorcontrib><creatorcontrib>Shimoyama, K.</creatorcontrib><creatorcontrib>Shimonaka, M.</creatorcontrib><creatorcontrib>Ishido, M.</creatorcontrib><creatorcontrib>Hirose, S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shionoiri, H.</au><au>Hirawa, N.</au><au>Takasaki, I.</au><au>Ishikawa, Y.</au><au>Minamisawa, K.</au><au>Miyajima, E.</au><au>Kinoshita, Y.</au><au>Shimoyama, K.</au><au>Shimonaka, M.</au><au>Ishido, M.</au><au>Hirose, S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Presence of functional receptors for atrial natriuretic peptide in human pheochromocytoma</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>1987-10-14</date><risdate>1987</risdate><volume>148</volume><issue>1</issue><spage>286</spage><epage>291</epage><pages>286-291</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><coden>BBRCA9</coden><abstract>Pheochromocytoma, a catecholamine-secreting adrenomedullary tumor, has been shown to contain the functional receptor for human atrial natriuretic peptide(h-ANP). Release of catecholamines from tissue slices of pheochromocytoma was inhibited by h-ANP in a dose-dependent manner. Binding assays using
125I-ANP revealed a single class of high affinity binding sites for ANP. When covalently tagged with
125I-ANP and electrophoresed under non-reducing and reducing conditions, the receptor migrated as a 140-kDa band and a 70-kDa band, respectively, reflecting its disulfide-linked subunit structure. The presence of ANP receptor in pheochromocytoma was further demonstrated by immuno-histochemistry; the tumor was positively stained with an anti-receptor antiserum. The antiserum was also useful to establish the zona glomerulosa localization of ANP receptor in the normal human adrenal gland.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>2823805</pmid><doi>10.1016/0006-291X(87)91108-9</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-291X |
| ispartof | Biochemical and biophysical research communications, 1987-10, Vol.148 (1), p.286-291 |
| issn | 0006-291X 1090-2104 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_81103925 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adrenal Gland Neoplasms - metabolism Adrenal Gland Neoplasms - pathology Applied sciences Atrial Natriuretic Factor - metabolism Atrial Natriuretic Factor - pharmacology atrial natriuretic hormone Epinephrine - metabolism Exact sciences and technology Humans In Vitro Techniques Kinetics man Norepinephrine - metabolism Other techniques and industries Pheochromocytoma - metabolism Pheochromocytoma - pathology pheochromocytoma cells Receptors, Atrial Natriuretic Factor Receptors, Cell Surface - metabolism |
| title | Presence of functional receptors for atrial natriuretic peptide in human pheochromocytoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T13%3A50%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Presence%20of%20functional%20receptors%20for%20atrial%20natriuretic%20peptide%20in%20human%20pheochromocytoma&rft.jtitle=Biochemical%20and%20biophysical%20research%20communications&rft.au=Shionoiri,%20H.&rft.date=1987-10-14&rft.volume=148&rft.issue=1&rft.spage=286&rft.epage=291&rft.pages=286-291&rft.issn=0006-291X&rft.eissn=1090-2104&rft.coden=BBRCA9&rft_id=info:doi/10.1016/0006-291X(87)91108-9&rft_dat=%3Cproquest_cross%3E14864846%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=14864846&rft_id=info:pmid/2823805&rft_els_id=0006291X87911089&rfr_iscdi=true |