Effect of proglumide, a cholecystokinin receptor antagonist, on caerulein-stimulated pancreatic enzyme secretion and pancreatic polypeptide release in the dog
In five conscious dogs we studied the effect of proglumide, a cholecystokinin (CCK) antagonist, on caerulein-stimulated pancreatic secretion and release of pancreatic polypeptide (PP). Graded doses of caerulein (15–240 ng/kg per h) were infused intravenously. Experiments were repeated with a fixed i...
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| Veröffentlicht in: | Regulatory peptides 1984-03, Vol.8 (2), p.117-122 |
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| container_title | Regulatory peptides |
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| creator | Fried, Michael Beglinger, Christoph Koehler, Erich Whitehouse, Ian Varga, Laszlo Gyr, Klaus |
| description | In five conscious dogs we studied the effect of proglumide, a cholecystokinin (CCK) antagonist, on caerulein-stimulated pancreatic secretion and release of pancreatic polypeptide (PP). Graded doses of caerulein (15–240 ng/kg per h) were infused intravenously. Experiments were repeated with a fixed infusion of proglumide (40 mg/kg per h). Release of PP following increasing doses of caerulein was significantly inhibited by proglumide (
P < 0.01). However, proglumide did not significantly affect caerulein-stimulated pancreatic protein secretion. Proglumide might be useful in defining the physiological role of CCK. |
| doi_str_mv | 10.1016/0167-0115(84)90166-6 |
| format | Article |
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P < 0.01). However, proglumide did not significantly affect caerulein-stimulated pancreatic protein secretion. Proglumide might be useful in defining the physiological role of CCK.</description><identifier>ISSN: 0167-0115</identifier><identifier>EISSN: 1873-1686</identifier><identifier>DOI: 10.1016/0167-0115(84)90166-6</identifier><identifier>PMID: 6729149</identifier><identifier>CODEN: REPPDY</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Animals ; Biological and medical sciences ; Ceruletide - pharmacology ; Cholecystokinin - antagonists & inhibitors ; Depression, Chemical ; Dogs ; Dose-Response Relationship, Drug ; Endocrine pancreas ; Fundamental and applied biological sciences. Psychology ; Glutamine - analogs & derivatives ; Hormones. Régulation ; Pancreas - drug effects ; Pancreas - metabolism ; Pancreatic Juice - metabolism ; pancreatic polypeptide ; Pancreatic Polypeptide - metabolism ; pancreatic secretion ; proglumide ; Proglumide - pharmacology ; Vertebrates: endocrinology</subject><ispartof>Regulatory peptides, 1984-03, Vol.8 (2), p.117-122</ispartof><rights>1984</rights><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-d2c5d835042df94d2c66d8807d8cc8b34ee5df2ef6d90b6b91f6ecbb10a604e33</citedby><cites>FETCH-LOGICAL-c386t-d2c5d835042df94d2c66d8807d8cc8b34ee5df2ef6d90b6b91f6ecbb10a604e33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0167-0115(84)90166-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9709485$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6729149$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fried, Michael</creatorcontrib><creatorcontrib>Beglinger, Christoph</creatorcontrib><creatorcontrib>Koehler, Erich</creatorcontrib><creatorcontrib>Whitehouse, Ian</creatorcontrib><creatorcontrib>Varga, Laszlo</creatorcontrib><creatorcontrib>Gyr, Klaus</creatorcontrib><title>Effect of proglumide, a cholecystokinin receptor antagonist, on caerulein-stimulated pancreatic enzyme secretion and pancreatic polypeptide release in the dog</title><title>Regulatory peptides</title><addtitle>Regul Pept</addtitle><description>In five conscious dogs we studied the effect of proglumide, a cholecystokinin (CCK) antagonist, on caerulein-stimulated pancreatic secretion and release of pancreatic polypeptide (PP). Graded doses of caerulein (15–240 ng/kg per h) were infused intravenously. Experiments were repeated with a fixed infusion of proglumide (40 mg/kg per h). Release of PP following increasing doses of caerulein was significantly inhibited by proglumide (
P < 0.01). However, proglumide did not significantly affect caerulein-stimulated pancreatic protein secretion. Proglumide might be useful in defining the physiological role of CCK.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Ceruletide - pharmacology</subject><subject>Cholecystokinin - antagonists & inhibitors</subject><subject>Depression, Chemical</subject><subject>Dogs</subject><subject>Dose-Response Relationship, Drug</subject><subject>Endocrine pancreas</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glutamine - analogs & derivatives</subject><subject>Hormones. Régulation</subject><subject>Pancreas - drug effects</subject><subject>Pancreas - metabolism</subject><subject>Pancreatic Juice - metabolism</subject><subject>pancreatic polypeptide</subject><subject>Pancreatic Polypeptide - metabolism</subject><subject>pancreatic secretion</subject><subject>proglumide</subject><subject>Proglumide - pharmacology</subject><subject>Vertebrates: endocrinology</subject><issn>0167-0115</issn><issn>1873-1686</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9Uc2KFDEYDKKs4-obKOQgorCtyXQ6nVwEWdYfWPCi55BOvsxG00mbpIXxYXxWM84w4MVDCF-qvqpQhdBTSl5TQvmbdsaOUDq8FOyVbBPv-D20oWLsO8oFv482Z8pD9KiUb4TQYRz7C3TBx62kTG7Q7xvnwFScHF5y2oV19hausMbmLgUw-1LTdx99xBkMLDVlrGPVuxR9qVc4RWw05DWAj12pfl6DrmDxoqPJoKs3GOKv_Qy4QHuovi3o-A--pLBfmnKzbR4BdAHc7OodYJt2j9EDp0OBJ6f7En19f_Pl-mN3-_nDp-t3t53pBa-d3ZrBin4gbGudZG3k3ApBRiuMEVPPAAbrtuC4lWTik6SOg5kmSjQnDPr-Er046rYQfqxQqpp9MRCCjpDWogQlUtLhQGRHosmplAxOLdnPOu8VJepQizpkrg6ZK8HU31oUb2vPTvrrNIM9L516aPjzE66L0cHlFpAvZ5ociWRiaLS3Rxq0LH56yKoYD9GA9a2fqmzy___HH_XIrbU</recordid><startdate>198403</startdate><enddate>198403</enddate><creator>Fried, Michael</creator><creator>Beglinger, Christoph</creator><creator>Koehler, Erich</creator><creator>Whitehouse, Ian</creator><creator>Varga, Laszlo</creator><creator>Gyr, Klaus</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198403</creationdate><title>Effect of proglumide, a cholecystokinin receptor antagonist, on caerulein-stimulated pancreatic enzyme secretion and pancreatic polypeptide release in the dog</title><author>Fried, Michael ; Beglinger, Christoph ; Koehler, Erich ; Whitehouse, Ian ; Varga, Laszlo ; Gyr, Klaus</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-d2c5d835042df94d2c66d8807d8cc8b34ee5df2ef6d90b6b91f6ecbb10a604e33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Ceruletide - pharmacology</topic><topic>Cholecystokinin - antagonists & inhibitors</topic><topic>Depression, Chemical</topic><topic>Dogs</topic><topic>Dose-Response Relationship, Drug</topic><topic>Endocrine pancreas</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glutamine - analogs & derivatives</topic><topic>Hormones. Régulation</topic><topic>Pancreas - drug effects</topic><topic>Pancreas - metabolism</topic><topic>Pancreatic Juice - metabolism</topic><topic>pancreatic polypeptide</topic><topic>Pancreatic Polypeptide - metabolism</topic><topic>pancreatic secretion</topic><topic>proglumide</topic><topic>Proglumide - pharmacology</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fried, Michael</creatorcontrib><creatorcontrib>Beglinger, Christoph</creatorcontrib><creatorcontrib>Koehler, Erich</creatorcontrib><creatorcontrib>Whitehouse, Ian</creatorcontrib><creatorcontrib>Varga, Laszlo</creatorcontrib><creatorcontrib>Gyr, Klaus</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Regulatory peptides</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fried, Michael</au><au>Beglinger, Christoph</au><au>Koehler, Erich</au><au>Whitehouse, Ian</au><au>Varga, Laszlo</au><au>Gyr, Klaus</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of proglumide, a cholecystokinin receptor antagonist, on caerulein-stimulated pancreatic enzyme secretion and pancreatic polypeptide release in the dog</atitle><jtitle>Regulatory peptides</jtitle><addtitle>Regul Pept</addtitle><date>1984-03</date><risdate>1984</risdate><volume>8</volume><issue>2</issue><spage>117</spage><epage>122</epage><pages>117-122</pages><issn>0167-0115</issn><eissn>1873-1686</eissn><coden>REPPDY</coden><abstract>In five conscious dogs we studied the effect of proglumide, a cholecystokinin (CCK) antagonist, on caerulein-stimulated pancreatic secretion and release of pancreatic polypeptide (PP). Graded doses of caerulein (15–240 ng/kg per h) were infused intravenously. Experiments were repeated with a fixed infusion of proglumide (40 mg/kg per h). Release of PP following increasing doses of caerulein was significantly inhibited by proglumide (
P < 0.01). However, proglumide did not significantly affect caerulein-stimulated pancreatic protein secretion. Proglumide might be useful in defining the physiological role of CCK.</abstract><cop>Shannon</cop><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>6729149</pmid><doi>10.1016/0167-0115(84)90166-6</doi><tpages>6</tpages></addata></record> |
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| ispartof | Regulatory peptides, 1984-03, Vol.8 (2), p.117-122 |
| issn | 0167-0115 1873-1686 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Biological and medical sciences Ceruletide - pharmacology Cholecystokinin - antagonists & inhibitors Depression, Chemical Dogs Dose-Response Relationship, Drug Endocrine pancreas Fundamental and applied biological sciences. Psychology Glutamine - analogs & derivatives Hormones. Régulation Pancreas - drug effects Pancreas - metabolism Pancreatic Juice - metabolism pancreatic polypeptide Pancreatic Polypeptide - metabolism pancreatic secretion proglumide Proglumide - pharmacology Vertebrates: endocrinology |
| title | Effect of proglumide, a cholecystokinin receptor antagonist, on caerulein-stimulated pancreatic enzyme secretion and pancreatic polypeptide release in the dog |
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