Immunoaffinity purification of membrane protein constituents of the IM-9 lymphoblast receptor for substance P

Substance P (SP) is an undecapeptide neuromediator that stimulates human T-lymphocyte function by binding to stereospecific membrane receptors. Human IM-9 cultured B-lymphoblasts express approximately 20,000 receptors per cell for [ 125I]SP with a K d of 0.3 nM. [ 125I]SP was specifically crosslinke...

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