Response of local blood flow in the caudate nucleus of the cat to intraventricular administration of carbachol
The effect of perfusion of the cerebral ventricles with artificial cerebrospinal fluid containing carbachol on the blood flow in the caudate nucleus of the cat and the possibility to inhibit this effect by anticholinergic drugs was studied by means of the hydrogen clearance technique. After a contro...
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| Veröffentlicht in: | Stroke (1970) 1984-05, Vol.15 (3), p.481-486 |
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| container_title | Stroke (1970) |
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| creator | DE LEY, G WEYNE, J DEMEESTER, G LEUSEN, I |
| description | The effect of perfusion of the cerebral ventricles with artificial cerebrospinal fluid containing carbachol on the blood flow in the caudate nucleus of the cat and the possibility to inhibit this effect by anticholinergic drugs was studied by means of the hydrogen clearance technique. After a control period during which both lateral ventricles were perfused with artificial CSF of identical composition, the drug under study was added on one side (experimental side) while the other side continued to be perfused with the control artificial CSF (control side). The blood flow on the experimental side and on the control side were compared. A dose dependent response to carbachol was observed. Lower concentrations of carbachol (10(-6) up to 10(-4)M) caused vasodilatation whereas high concentrations (10(-3)M) caused local vasoconstriction. The increase in the local blood flow caused by the low carbachol concentrations was reduced by both atropine (10(-5)M) and hexamethonium (10(-3)M). The fall in CBF observed with the high carbachol concentration was prevented by atropine (10(-5)M). It may be concluded that low, physiologically more meaningful, carbachol concentrations cause a local vasodilatation due to interaction with both muscarinic and nicotinic receptors. |
| doi_str_mv | 10.1161/01.STR.15.3.481 |
| format | Article |
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After a control period during which both lateral ventricles were perfused with artificial CSF of identical composition, the drug under study was added on one side (experimental side) while the other side continued to be perfused with the control artificial CSF (control side). The blood flow on the experimental side and on the control side were compared. A dose dependent response to carbachol was observed. Lower concentrations of carbachol (10(-6) up to 10(-4)M) caused vasodilatation whereas high concentrations (10(-3)M) caused local vasoconstriction. The increase in the local blood flow caused by the low carbachol concentrations was reduced by both atropine (10(-5)M) and hexamethonium (10(-3)M). The fall in CBF observed with the high carbachol concentration was prevented by atropine (10(-5)M). It may be concluded that low, physiologically more meaningful, carbachol concentrations cause a local vasodilatation due to interaction with both muscarinic and nicotinic receptors.</description><identifier>ISSN: 0039-2499</identifier><identifier>EISSN: 1524-4628</identifier><identifier>DOI: 10.1161/01.STR.15.3.481</identifier><identifier>PMID: 6145238</identifier><identifier>CODEN: SJCCA7</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Animals ; Atropine - pharmacology ; Biological and medical sciences ; Carbachol - antagonists & inhibitors ; Carbachol - pharmacology ; Cats ; Caudate Nucleus - blood supply ; Caudate Nucleus - drug effects ; Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges ; Cerebrovascular Circulation - drug effects ; Dose-Response Relationship, Drug ; Female ; Fundamental and applied biological sciences. Psychology ; Hexamethonium ; Hexamethonium Compounds - pharmacology ; Injections, Intraventricular ; Male ; Vertebrates: nervous system and sense organs</subject><ispartof>Stroke (1970), 1984-05, Vol.15 (3), p.481-486</ispartof><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-76171323fbe5665f11ce38862801f84df2ea05835a16c651b9016ed619fc114b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3687,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8856921$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6145238$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DE LEY, G</creatorcontrib><creatorcontrib>WEYNE, J</creatorcontrib><creatorcontrib>DEMEESTER, G</creatorcontrib><creatorcontrib>LEUSEN, I</creatorcontrib><title>Response of local blood flow in the caudate nucleus of the cat to intraventricular administration of carbachol</title><title>Stroke (1970)</title><addtitle>Stroke</addtitle><description>The effect of perfusion of the cerebral ventricles with artificial cerebrospinal fluid containing carbachol on the blood flow in the caudate nucleus of the cat and the possibility to inhibit this effect by anticholinergic drugs was studied by means of the hydrogen clearance technique. After a control period during which both lateral ventricles were perfused with artificial CSF of identical composition, the drug under study was added on one side (experimental side) while the other side continued to be perfused with the control artificial CSF (control side). The blood flow on the experimental side and on the control side were compared. A dose dependent response to carbachol was observed. Lower concentrations of carbachol (10(-6) up to 10(-4)M) caused vasodilatation whereas high concentrations (10(-3)M) caused local vasoconstriction. The increase in the local blood flow caused by the low carbachol concentrations was reduced by both atropine (10(-5)M) and hexamethonium (10(-3)M). The fall in CBF observed with the high carbachol concentration was prevented by atropine (10(-5)M). It may be concluded that low, physiologically more meaningful, carbachol concentrations cause a local vasodilatation due to interaction with both muscarinic and nicotinic receptors.</description><subject>Animals</subject><subject>Atropine - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Carbachol - antagonists & inhibitors</subject><subject>Carbachol - pharmacology</subject><subject>Cats</subject><subject>Caudate Nucleus - blood supply</subject><subject>Caudate Nucleus - drug effects</subject><subject>Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges</subject><subject>Cerebrovascular Circulation - drug effects</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hexamethonium</subject><subject>Hexamethonium Compounds - pharmacology</subject><subject>Injections, Intraventricular</subject><subject>Male</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0039-2499</issn><issn>1524-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctLBDEMxosouj7OnoQexNvMNn1t5yjiCwRh1XPpdFoc6U7Xdkbxv7fLLl69JCH55YPkQ-gcSA0gYU6gfnld1iBqVnMFe2gGgvKKS6r20YwQ1lSUN80ROs75gxBCmRKH6FACF6WcoWHp8joO2eHocYjWBNyGGDvsQ_zG_YDHd4etmTozOjxMNrgpb9Bte8RjLNCYzJcrsbdTMAmbbtUPfS7dsY_DhrYmtca-x3CKDrwJ2Z3t8gl6u7t9vXmonp7vH2-unyrLqRqrhYQFMMp864SUwgNYx5QqRxHwineeOkOEYsKAtFJA2xCQrpPQeAvAW3aCrra66xQ_J5dHveqzdSGYwcUpawWkUaTh_4LA2UIsFC3gfAvaFHNOzut16lcm_WggemOFJqCLFRqEZrpYUTYudtJTu3LdH7_7fZlf7uYml7_7ZAbb5z9MKSEbCuwXR2mRRQ</recordid><startdate>198405</startdate><enddate>198405</enddate><creator>DE LEY, G</creator><creator>WEYNE, J</creator><creator>DEMEESTER, G</creator><creator>LEUSEN, I</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>198405</creationdate><title>Response of local blood flow in the caudate nucleus of the cat to intraventricular administration of carbachol</title><author>DE LEY, G ; WEYNE, J ; DEMEESTER, G ; LEUSEN, I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-76171323fbe5665f11ce38862801f84df2ea05835a16c651b9016ed619fc114b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Animals</topic><topic>Atropine - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Carbachol - antagonists & inhibitors</topic><topic>Carbachol - pharmacology</topic><topic>Cats</topic><topic>Caudate Nucleus - blood supply</topic><topic>Caudate Nucleus - drug effects</topic><topic>Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges</topic><topic>Cerebrovascular Circulation - drug effects</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hexamethonium</topic><topic>Hexamethonium Compounds - pharmacology</topic><topic>Injections, Intraventricular</topic><topic>Male</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DE LEY, G</creatorcontrib><creatorcontrib>WEYNE, J</creatorcontrib><creatorcontrib>DEMEESTER, G</creatorcontrib><creatorcontrib>LEUSEN, I</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Stroke (1970)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DE LEY, G</au><au>WEYNE, J</au><au>DEMEESTER, G</au><au>LEUSEN, I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Response of local blood flow in the caudate nucleus of the cat to intraventricular administration of carbachol</atitle><jtitle>Stroke (1970)</jtitle><addtitle>Stroke</addtitle><date>1984-05</date><risdate>1984</risdate><volume>15</volume><issue>3</issue><spage>481</spage><epage>486</epage><pages>481-486</pages><issn>0039-2499</issn><eissn>1524-4628</eissn><coden>SJCCA7</coden><abstract>The effect of perfusion of the cerebral ventricles with artificial cerebrospinal fluid containing carbachol on the blood flow in the caudate nucleus of the cat and the possibility to inhibit this effect by anticholinergic drugs was studied by means of the hydrogen clearance technique. After a control period during which both lateral ventricles were perfused with artificial CSF of identical composition, the drug under study was added on one side (experimental side) while the other side continued to be perfused with the control artificial CSF (control side). The blood flow on the experimental side and on the control side were compared. A dose dependent response to carbachol was observed. Lower concentrations of carbachol (10(-6) up to 10(-4)M) caused vasodilatation whereas high concentrations (10(-3)M) caused local vasoconstriction. The increase in the local blood flow caused by the low carbachol concentrations was reduced by both atropine (10(-5)M) and hexamethonium (10(-3)M). The fall in CBF observed with the high carbachol concentration was prevented by atropine (10(-5)M). It may be concluded that low, physiologically more meaningful, carbachol concentrations cause a local vasodilatation due to interaction with both muscarinic and nicotinic receptors.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>6145238</pmid><doi>10.1161/01.STR.15.3.481</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; American Heart Association Journals; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Atropine - pharmacology Biological and medical sciences Carbachol - antagonists & inhibitors Carbachol - pharmacology Cats Caudate Nucleus - blood supply Caudate Nucleus - drug effects Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges Cerebrovascular Circulation - drug effects Dose-Response Relationship, Drug Female Fundamental and applied biological sciences. Psychology Hexamethonium Hexamethonium Compounds - pharmacology Injections, Intraventricular Male Vertebrates: nervous system and sense organs |
| title | Response of local blood flow in the caudate nucleus of the cat to intraventricular administration of carbachol |
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