Imaging of inflammatory processes with labeled cells
Radionuclide techniques for localizing inflammatory processes had relied heavily upon 67Ga-citrate until McAfee and Thakur described the technique for the radiolabeling of leukocytes with 111In-oxine. Since their initial description in 1976 there has been continued development of the radiopharmaceut...
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| Veröffentlicht in: | Semin. Nucl. Med.; (United States) 1984-04, Vol.14 (2), p.128-140 |
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| creator | Froelich, J.W. Swanson, Dennis |
| description | Radionuclide techniques for localizing inflammatory processes had relied heavily upon
67Ga-citrate until McAfee and Thakur described the technique for the radiolabeling of leukocytes with
111In-oxine. Since their initial description in 1976 there has been continued development of the radiopharmaceutical, as well as clinical efficacy. At present
111In-labeled leukocytes continue to be handled as an investigational new drug but this has not greatly limited its clinical availability. Indium-111 leukocytes are the agent of choice for evaluation of patients with fever of unknown origin, osteomyelitis, and prosthetic graft infections; and preliminary data shows great promise in the area of detecting reocurrence of inflammatory bowel disease. This article attempts to review currently accepted uses of
111In leukocytes as well as potential areas of application. |
| doi_str_mv | 10.1016/S0001-2998(84)80026-4 |
| format | Article |
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67Ga-citrate until McAfee and Thakur described the technique for the radiolabeling of leukocytes with
111In-oxine. Since their initial description in 1976 there has been continued development of the radiopharmaceutical, as well as clinical efficacy. At present
111In-labeled leukocytes continue to be handled as an investigational new drug but this has not greatly limited its clinical availability. Indium-111 leukocytes are the agent of choice for evaluation of patients with fever of unknown origin, osteomyelitis, and prosthetic graft infections; and preliminary data shows great promise in the area of detecting reocurrence of inflammatory bowel disease. This article attempts to review currently accepted uses of
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67Ga-citrate until McAfee and Thakur described the technique for the radiolabeling of leukocytes with
111In-oxine. Since their initial description in 1976 there has been continued development of the radiopharmaceutical, as well as clinical efficacy. At present
111In-labeled leukocytes continue to be handled as an investigational new drug but this has not greatly limited its clinical availability. Indium-111 leukocytes are the agent of choice for evaluation of patients with fever of unknown origin, osteomyelitis, and prosthetic graft infections; and preliminary data shows great promise in the area of detecting reocurrence of inflammatory bowel disease. This article attempts to review currently accepted uses of
111In leukocytes as well as potential areas of application.</description><subject>550601 - Medicine- Unsealed Radionuclides in Diagnostics</subject><subject>Abscess - diagnostic imaging</subject><subject>ABSCESSES</subject><subject>ANIMALS</subject><subject>BETA DECAY RADIOISOTOPES</subject><subject>Biological and medical sciences</subject><subject>BIOLOGICAL MATERIALS</subject><subject>BLOOD</subject><subject>BLOOD CELLS</subject><subject>Blood Vessel Prosthesis</subject><subject>BODY FLUIDS</subject><subject>CARBOXYLIC ACID SALTS</subject><subject>CITRATES</subject><subject>Colitis, Ulcerative - diagnostic imaging</subject><subject>COUNTING TECHNIQUES</subject><subject>Crohn Disease - diagnostic imaging</subject><subject>Cytomegalovirus Infections - diagnostic imaging</subject><subject>DAYS LIVING RADIOISOTOPES</subject><subject>DIAGNOSIS</subject><subject>DISEASES</subject><subject>ELECTRON CAPTURE RADIOISOTOPES</subject><subject>Enterocolitis, Pseudomembranous - diagnostic imaging</subject><subject>Fever of Unknown Origin - diagnostic imaging</subject><subject>GALLIUM 67</subject><subject>GALLIUM ISOTOPES</subject><subject>Gallium Radioisotopes</subject><subject>Humans</subject><subject>Indium</subject><subject>INDIUM 111</subject><subject>INDIUM ISOTOPES</subject><subject>Infection - diagnostic imaging</subject><subject>INFECTIOUS DISEASES</subject><subject>INFLAMMATION</subject><subject>Inflammation - diagnostic imaging</subject><subject>INTERMEDIATE MASS NUCLEI</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>ISOMERIC TRANSITION ISOTOPES</subject><subject>ISOTOPES</subject><subject>LEUKOCYTES</subject><subject>Liver Abscess - diagnostic imaging</subject><subject>MAMMALS</subject><subject>MAN</subject><subject>MATERIALS</subject><subject>Medical sciences</subject><subject>MINUTES LIVING RADIOISOTOPES</subject><subject>NUCLEI</subject><subject>ODD-EVEN NUCLEI</subject><subject>Organometallic Compounds</subject><subject>OSTEOMYELITIS</subject><subject>Osteomyelitis - diagnostic imaging</subject><subject>Oxyquinoline - analogs & derivatives</subject><subject>Pancreatic Diseases - diagnostic imaging</subject><subject>PATHOLOGICAL CHANGES</subject><subject>PRIMATES</subject><subject>RADIOISOTOPE SCANNING</subject><subject>RADIOISOTOPES</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>Radionuclide Imaging</subject><subject>Radionuclide investigations</subject><subject>SKELETAL DISEASES</subject><subject>SYMPTOMS</subject><subject>VERTEBRATES</subject><issn>0001-2998</issn><issn>1558-4623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMlKBDEQhoMo47g8gtCIiB5as1TS6ZOIuMGAB_Uc0pmKRnrRpEfx7e2eGebqKQX1VeWvj5AjRi8YZerymVLKcl6W-kzDuaaUqxy2yJRJqXNQXGyT6QbZJXspfQyMlKWckIkSXCulpwQeG_sW2res81lofW2bxvZd_M0-Y-cwJUzZT-jfs9pWWOM8c1jX6YDseFsnPFy_--T17vbl5iGfPd0_3lzPcgcg-7wCXTCuZIG2Kj2Al0IB6MpWIKSCwiHzinnJXVVYVoDyHD0VAqSsrB6KfXK82tulPpjkQo_u3XVti643ilPBl9DpChoSfy0w9aYJaYxpW-wWyWhGSyUUHUC5Al3sUorozWcMjY2_hlEzKjVLpWb0ZTSYpVIDw9zR-oNF1eB8M7V2OPRP1n2bnK19tK0LaYOVqmCFGLGrFYaDse-AcTwIW4fzEMd75l34J8gf3aSQdQ</recordid><startdate>198404</startdate><enddate>198404</enddate><creator>Froelich, J.W.</creator><creator>Swanson, Dennis</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>198404</creationdate><title>Imaging of inflammatory processes with labeled cells</title><author>Froelich, J.W. ; Swanson, Dennis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-b48712657eab9f44f536448bab435647ce1f61f52cb7a1746f2ef033455ba8033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>550601 - Medicine- Unsealed Radionuclides in Diagnostics</topic><topic>Abscess - diagnostic imaging</topic><topic>ABSCESSES</topic><topic>ANIMALS</topic><topic>BETA DECAY RADIOISOTOPES</topic><topic>Biological and medical sciences</topic><topic>BIOLOGICAL MATERIALS</topic><topic>BLOOD</topic><topic>BLOOD CELLS</topic><topic>Blood Vessel Prosthesis</topic><topic>BODY FLUIDS</topic><topic>CARBOXYLIC ACID SALTS</topic><topic>CITRATES</topic><topic>Colitis, Ulcerative - diagnostic imaging</topic><topic>COUNTING TECHNIQUES</topic><topic>Crohn Disease - diagnostic imaging</topic><topic>Cytomegalovirus Infections - diagnostic imaging</topic><topic>DAYS LIVING RADIOISOTOPES</topic><topic>DIAGNOSIS</topic><topic>DISEASES</topic><topic>ELECTRON CAPTURE RADIOISOTOPES</topic><topic>Enterocolitis, Pseudomembranous - diagnostic imaging</topic><topic>Fever of Unknown Origin - diagnostic imaging</topic><topic>GALLIUM 67</topic><topic>GALLIUM ISOTOPES</topic><topic>Gallium Radioisotopes</topic><topic>Humans</topic><topic>Indium</topic><topic>INDIUM 111</topic><topic>INDIUM ISOTOPES</topic><topic>Infection - diagnostic imaging</topic><topic>INFECTIOUS DISEASES</topic><topic>INFLAMMATION</topic><topic>Inflammation - diagnostic imaging</topic><topic>INTERMEDIATE MASS NUCLEI</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>ISOMERIC TRANSITION ISOTOPES</topic><topic>ISOTOPES</topic><topic>LEUKOCYTES</topic><topic>Liver Abscess - diagnostic imaging</topic><topic>MAMMALS</topic><topic>MAN</topic><topic>MATERIALS</topic><topic>Medical sciences</topic><topic>MINUTES LIVING RADIOISOTOPES</topic><topic>NUCLEI</topic><topic>ODD-EVEN NUCLEI</topic><topic>Organometallic Compounds</topic><topic>OSTEOMYELITIS</topic><topic>Osteomyelitis - diagnostic imaging</topic><topic>Oxyquinoline - analogs & derivatives</topic><topic>Pancreatic Diseases - diagnostic imaging</topic><topic>PATHOLOGICAL CHANGES</topic><topic>PRIMATES</topic><topic>RADIOISOTOPE SCANNING</topic><topic>RADIOISOTOPES</topic><topic>RADIOLOGY AND NUCLEAR MEDICINE</topic><topic>Radionuclide Imaging</topic><topic>Radionuclide investigations</topic><topic>SKELETAL DISEASES</topic><topic>SYMPTOMS</topic><topic>VERTEBRATES</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Froelich, J.W.</creatorcontrib><creatorcontrib>Swanson, Dennis</creatorcontrib><creatorcontrib>Henry Ford Hospital, Detroit, MI</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Semin. Nucl. Med.; (United States)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Froelich, J.W.</au><au>Swanson, Dennis</au><aucorp>Henry Ford Hospital, Detroit, MI</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Imaging of inflammatory processes with labeled cells</atitle><jtitle>Semin. Nucl. Med.; (United States)</jtitle><addtitle>Semin Nucl Med</addtitle><date>1984-04</date><risdate>1984</risdate><volume>14</volume><issue>2</issue><spage>128</spage><epage>140</epage><pages>128-140</pages><issn>0001-2998</issn><eissn>1558-4623</eissn><coden>SMNMAB</coden><abstract>Radionuclide techniques for localizing inflammatory processes had relied heavily upon
67Ga-citrate until McAfee and Thakur described the technique for the radiolabeling of leukocytes with
111In-oxine. Since their initial description in 1976 there has been continued development of the radiopharmaceutical, as well as clinical efficacy. At present
111In-labeled leukocytes continue to be handled as an investigational new drug but this has not greatly limited its clinical availability. Indium-111 leukocytes are the agent of choice for evaluation of patients with fever of unknown origin, osteomyelitis, and prosthetic graft infections; and preliminary data shows great promise in the area of detecting reocurrence of inflammatory bowel disease. This article attempts to review currently accepted uses of
111In leukocytes as well as potential areas of application.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>6328668</pmid><doi>10.1016/S0001-2998(84)80026-4</doi><tpages>13</tpages></addata></record> |
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| ispartof | Semin. Nucl. Med.; (United States), 1984-04, Vol.14 (2), p.128-140 |
| issn | 0001-2998 1558-4623 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_81096360 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | 550601 - Medicine- Unsealed Radionuclides in Diagnostics Abscess - diagnostic imaging ABSCESSES ANIMALS BETA DECAY RADIOISOTOPES Biological and medical sciences BIOLOGICAL MATERIALS BLOOD BLOOD CELLS Blood Vessel Prosthesis BODY FLUIDS CARBOXYLIC ACID SALTS CITRATES Colitis, Ulcerative - diagnostic imaging COUNTING TECHNIQUES Crohn Disease - diagnostic imaging Cytomegalovirus Infections - diagnostic imaging DAYS LIVING RADIOISOTOPES DIAGNOSIS DISEASES ELECTRON CAPTURE RADIOISOTOPES Enterocolitis, Pseudomembranous - diagnostic imaging Fever of Unknown Origin - diagnostic imaging GALLIUM 67 GALLIUM ISOTOPES Gallium Radioisotopes Humans Indium INDIUM 111 INDIUM ISOTOPES Infection - diagnostic imaging INFECTIOUS DISEASES INFLAMMATION Inflammation - diagnostic imaging INTERMEDIATE MASS NUCLEI Investigative techniques, diagnostic techniques (general aspects) ISOMERIC TRANSITION ISOTOPES ISOTOPES LEUKOCYTES Liver Abscess - diagnostic imaging MAMMALS MAN MATERIALS Medical sciences MINUTES LIVING RADIOISOTOPES NUCLEI ODD-EVEN NUCLEI Organometallic Compounds OSTEOMYELITIS Osteomyelitis - diagnostic imaging Oxyquinoline - analogs & derivatives Pancreatic Diseases - diagnostic imaging PATHOLOGICAL CHANGES PRIMATES RADIOISOTOPE SCANNING RADIOISOTOPES RADIOLOGY AND NUCLEAR MEDICINE Radionuclide Imaging Radionuclide investigations SKELETAL DISEASES SYMPTOMS VERTEBRATES |
| title | Imaging of inflammatory processes with labeled cells |
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