5-Hydroxytryptamine (5-HT)-dependent myoclonus in guinea pigs is induced through brainstem 5-HT-1 receptors

Myoclonic jerking in guinea pigs originates from the brainstem. Indole-containing 5-hydroxytryptamine (5-HT) agonists, but not piperazine-containing 5-HT agonists, induced myoclonus in guinea pigs at pharmacologically relevant doses. Guinea pig brainstem preparations possessed specific binding sites...

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Veröffentlicht in:	Neuroscience letters 1984-02, Vol.44 (3), p.241-246
Hauptverfasser:	Luscombe, Graham, Jenner, Peter, Marsden, C.David
Format:	Artikel
Sprache:	eng
Schlagworte:	5-HT agonists 5-HT receptors 5-HT-dependent myoclonus [ 3H]5-HT [ 3H]spiperone Animals Binding Sites Binding, Competitive Biological and medical sciences Brain Stem - metabolism Brain Stem - physiopathology brainstem Female guinea pig Guinea Pigs Medical sciences Myoclonus - physiopathology Nervous system (semeiology, syndromes) Nervous system as a whole Neurology Receptors, Serotonin - physiology Serotonin - metabolism Serotonin - physiology Spiperone - metabolism
Online-Zugang:	Volltext
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