Evidence of Extrachromosomal Forms of Hepatitis B Viral DNA in a Bone Marrow Culture Obtained from a Patient Recently Infected with Hepatitis B Virus

A cell culture that produces Dane-like particles was initiated from a bone marrow aspirate of an acute hepatitis B patient. By using Southern blot analysis and a recombinant hepatitis B virus (HBV) DNA plasmid probe, extrachromosomal forms of HBV DNA were detected. The two forms of HBV DNA migrate a...

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