Effect of intermittent infusions of glucose-containing crystalloid cardioplegic solution on myocardial tissue lactic acid and recovery of contractility
The objective of this study was to determine the effects of single or intermittent infusions of cardioplegic solution with glucose (5 gm/L) or without glucose on myocardial tissue lactic acid and recovery of myocardial contractility following 80 minutes of total ischemia at 28 degrees C in the isola...
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| Veröffentlicht in: | The Journal of thoracic and cardiovascular surgery 1984-06, Vol.87 (6), p.920-929 |
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| container_title | The Journal of thoracic and cardiovascular surgery |
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| creator | Guilbeau, EJ Moore, LK Viole, AJ Mathis, TR Switzer, AJ Brandon, TA Martin, M Fisk, RL |
| description | The objective of this study was to determine the effects of single or intermittent infusions of cardioplegic solution with glucose (5 gm/L) or without glucose on myocardial tissue lactic acid and recovery of myocardial contractility following 80 minutes of total ischemia at 28 degrees C in the isolated, blood-perfused, beating rabbit heart. Ischemia without cardioplegia increased tissue lactic acid (6.79 mg/gm tissue) above the control value (0.9 mg/gm tissue), p less than 0.0025). Lactic acid following single infusions with (4.19 mg/gm tissue) or without glucose (3.67 mg/gm tissue) was significantly greater (p less than 0.0025) than tissue lactic acid following intermittent infusions with (1.06 mg/gm tissue) or without glucose (1.05 mg/gm tissue). Cardioplegic arrest in all cases significantly decreased tissue lactate accumulation when compared to arrest without cardioplegia (p less than 0.01). The decrease in myocardial contractility demonstrated when no cardioplegic protection was employed (86% recovery) was completely eliminated (100% recovery) with a single-bolus infusion of cardioplegic solution containing glucose (p less 0.025). Intermittent infusions of cardioplegic solution containing glucose (92% recovery) and single infusions without glucose (93% recovery) also improved recovery of contractility following ischemia, but the results were not statistically significant. |
| doi_str_mv | 10.1016/s0022-5223(19)38423-5 |
| format | Article |
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Ischemia without cardioplegia increased tissue lactic acid (6.79 mg/gm tissue) above the control value (0.9 mg/gm tissue), p less than 0.0025). Lactic acid following single infusions with (4.19 mg/gm tissue) or without glucose (3.67 mg/gm tissue) was significantly greater (p less than 0.0025) than tissue lactic acid following intermittent infusions with (1.06 mg/gm tissue) or without glucose (1.05 mg/gm tissue). Cardioplegic arrest in all cases significantly decreased tissue lactate accumulation when compared to arrest without cardioplegia (p less than 0.01). The decrease in myocardial contractility demonstrated when no cardioplegic protection was employed (86% recovery) was completely eliminated (100% recovery) with a single-bolus infusion of cardioplegic solution containing glucose (p less 0.025). Intermittent infusions of cardioplegic solution containing glucose (92% recovery) and single infusions without glucose (93% recovery) also improved recovery of contractility following ischemia, but the results were not statistically significant.</description><identifier>ISSN: 0022-5223</identifier><identifier>EISSN: 1097-685X</identifier><identifier>DOI: 10.1016/s0022-5223(19)38423-5</identifier><identifier>PMID: 6727413</identifier><identifier>CODEN: JTCSAQ</identifier><language>eng</language><publisher>Philadelphia, PA: AATS/WTSA</publisher><subject>Anesthesia ; Anesthesia depending on type of surgery ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Animals ; Biological and medical sciences ; Coronary Disease - metabolism ; Coronary Disease - physiopathology ; Glucose - pharmacology ; In Vitro Techniques ; Lactates - metabolism ; Lactic Acid ; Medical sciences ; Myocardial Contraction - drug effects ; Myocardium - metabolism ; Potassium - administration & dosage ; Potassium - pharmacology ; Potassium Compounds ; Rabbits ; Thoracic and cardiovascular surgery. Cardiopulmonary bypass</subject><ispartof>The Journal of thoracic and cardiovascular surgery, 1984-06, Vol.87 (6), p.920-929</ispartof><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c364t-609e1dd4a82815c467da380f10db907e4e2e1a8ea87eb9e98f61b156f48113363</citedby><cites>FETCH-LOGICAL-c364t-609e1dd4a82815c467da380f10db907e4e2e1a8ea87eb9e98f61b156f48113363</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9622833$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6727413$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guilbeau, EJ</creatorcontrib><creatorcontrib>Moore, LK</creatorcontrib><creatorcontrib>Viole, AJ</creatorcontrib><creatorcontrib>Mathis, TR</creatorcontrib><creatorcontrib>Switzer, AJ</creatorcontrib><creatorcontrib>Brandon, TA</creatorcontrib><creatorcontrib>Martin, M</creatorcontrib><creatorcontrib>Fisk, RL</creatorcontrib><title>Effect of intermittent infusions of glucose-containing crystalloid cardioplegic solution on myocardial tissue lactic acid and recovery of contractility</title><title>The Journal of thoracic and cardiovascular surgery</title><addtitle>J Thorac Cardiovasc Surg</addtitle><description>The objective of this study was to determine the effects of single or intermittent infusions of cardioplegic solution with glucose (5 gm/L) or without glucose on myocardial tissue lactic acid and recovery of myocardial contractility following 80 minutes of total ischemia at 28 degrees C in the isolated, blood-perfused, beating rabbit heart. Ischemia without cardioplegia increased tissue lactic acid (6.79 mg/gm tissue) above the control value (0.9 mg/gm tissue), p less than 0.0025). Lactic acid following single infusions with (4.19 mg/gm tissue) or without glucose (3.67 mg/gm tissue) was significantly greater (p less than 0.0025) than tissue lactic acid following intermittent infusions with (1.06 mg/gm tissue) or without glucose (1.05 mg/gm tissue). Cardioplegic arrest in all cases significantly decreased tissue lactate accumulation when compared to arrest without cardioplegia (p less than 0.01). The decrease in myocardial contractility demonstrated when no cardioplegic protection was employed (86% recovery) was completely eliminated (100% recovery) with a single-bolus infusion of cardioplegic solution containing glucose (p less 0.025). Intermittent infusions of cardioplegic solution containing glucose (92% recovery) and single infusions without glucose (93% recovery) also improved recovery of contractility following ischemia, but the results were not statistically significant.</description><subject>Anesthesia</subject><subject>Anesthesia depending on type of surgery</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Coronary Disease - metabolism</subject><subject>Coronary Disease - physiopathology</subject><subject>Glucose - pharmacology</subject><subject>In Vitro Techniques</subject><subject>Lactates - metabolism</subject><subject>Lactic Acid</subject><subject>Medical sciences</subject><subject>Myocardial Contraction - drug effects</subject><subject>Myocardium - metabolism</subject><subject>Potassium - administration & dosage</subject><subject>Potassium - pharmacology</subject><subject>Potassium Compounds</subject><subject>Rabbits</subject><subject>Thoracic and cardiovascular surgery. 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Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Coronary Disease - metabolism</topic><topic>Coronary Disease - physiopathology</topic><topic>Glucose - pharmacology</topic><topic>In Vitro Techniques</topic><topic>Lactates - metabolism</topic><topic>Lactic Acid</topic><topic>Medical sciences</topic><topic>Myocardial Contraction - drug effects</topic><topic>Myocardium - metabolism</topic><topic>Potassium - administration & dosage</topic><topic>Potassium - pharmacology</topic><topic>Potassium Compounds</topic><topic>Rabbits</topic><topic>Thoracic and cardiovascular surgery. Cardiopulmonary bypass</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guilbeau, EJ</creatorcontrib><creatorcontrib>Moore, LK</creatorcontrib><creatorcontrib>Viole, AJ</creatorcontrib><creatorcontrib>Mathis, TR</creatorcontrib><creatorcontrib>Switzer, AJ</creatorcontrib><creatorcontrib>Brandon, TA</creatorcontrib><creatorcontrib>Martin, M</creatorcontrib><creatorcontrib>Fisk, RL</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of thoracic and cardiovascular surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guilbeau, EJ</au><au>Moore, LK</au><au>Viole, AJ</au><au>Mathis, TR</au><au>Switzer, AJ</au><au>Brandon, TA</au><au>Martin, M</au><au>Fisk, RL</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of intermittent infusions of glucose-containing crystalloid cardioplegic solution on myocardial tissue lactic acid and recovery of contractility</atitle><jtitle>The Journal of thoracic and cardiovascular surgery</jtitle><addtitle>J Thorac Cardiovasc Surg</addtitle><date>1984-06</date><risdate>1984</risdate><volume>87</volume><issue>6</issue><spage>920</spage><epage>929</epage><pages>920-929</pages><issn>0022-5223</issn><eissn>1097-685X</eissn><coden>JTCSAQ</coden><abstract>The objective of this study was to determine the effects of single or intermittent infusions of cardioplegic solution with glucose (5 gm/L) or without glucose on myocardial tissue lactic acid and recovery of myocardial contractility following 80 minutes of total ischemia at 28 degrees C in the isolated, blood-perfused, beating rabbit heart. Ischemia without cardioplegia increased tissue lactic acid (6.79 mg/gm tissue) above the control value (0.9 mg/gm tissue), p less than 0.0025). Lactic acid following single infusions with (4.19 mg/gm tissue) or without glucose (3.67 mg/gm tissue) was significantly greater (p less than 0.0025) than tissue lactic acid following intermittent infusions with (1.06 mg/gm tissue) or without glucose (1.05 mg/gm tissue). Cardioplegic arrest in all cases significantly decreased tissue lactate accumulation when compared to arrest without cardioplegia (p less than 0.01). The decrease in myocardial contractility demonstrated when no cardioplegic protection was employed (86% recovery) was completely eliminated (100% recovery) with a single-bolus infusion of cardioplegic solution containing glucose (p less 0.025). 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| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Anesthesia Anesthesia depending on type of surgery Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Coronary Disease - metabolism Coronary Disease - physiopathology Glucose - pharmacology In Vitro Techniques Lactates - metabolism Lactic Acid Medical sciences Myocardial Contraction - drug effects Myocardium - metabolism Potassium - administration & dosage Potassium - pharmacology Potassium Compounds Rabbits Thoracic and cardiovascular surgery. Cardiopulmonary bypass |
| title | Effect of intermittent infusions of glucose-containing crystalloid cardioplegic solution on myocardial tissue lactic acid and recovery of contractility |
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