The quinolines PK 8165 and PK 9084 possess benzodiazepine-like activity in vitro but not in vivo
The quinolines PK 8165 and PK 9084 bind to brain benzodiazepine receptors in vitro. However, unlike diazepam, these molecules do not reduce GABA turnover, possess anxiolytic properties, or displace [ 3H]flunitrazepam from benzodiazepine receptors in vivo. The pharmacological properties of PK 8165 an...
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| Veröffentlicht in: | Neuroscience letters 1984-03, Vol.45 (1), p.89-93 |
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| container_end_page | 93 |
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| container_issue | 1 |
| container_start_page | 89 |
| container_title | Neuroscience letters |
| container_volume | 45 |
| creator | Keane, P.E. Simiand, J. Morre, M. |
| description | The quinolines PK 8165 and PK 9084 bind to brain benzodiazepine receptors in vitro. However, unlike diazepam, these molecules do not reduce GABA turnover, possess anxiolytic properties, or displace [
3H]flunitrazepam from benzodiazepine receptors in vivo. The pharmacological properties of PK 8165 and PK 9084 in vivo are thus unrelated to the benzodiazepine receptor. |
| doi_str_mv | 10.1016/0304-3940(84)90334-3 |
| format | Article |
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3H]flunitrazepam from benzodiazepine receptors in vivo. The pharmacological properties of PK 8165 and PK 9084 in vivo are thus unrelated to the benzodiazepine receptor.</description><subject>Animals</subject><subject>Anti-Anxiety Agents - pharmacology</subject><subject>anxiolytic</subject><subject>benzodiazepine receptor</subject><subject>Benzodiazepines - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Brain - metabolism</subject><subject>Diazepam - pharmacology</subject><subject>Flunitrazepam - metabolism</subject><subject>gamma-Aminobutyric Acid - biosynthesis</subject><subject>In Vitro Techniques</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>PK 8165</subject><subject>PK 9084</subject><subject>Psycholeptics: tranquillizer, neuroleptic</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>quinoline</subject><subject>Quinolines - pharmacology</subject><subject>Rats</subject><subject>Receptors, Cell Surface - metabolism</subject><subject>Receptors, GABA-A</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v1DAQhq0KVLaFf1AkH1AFh8D4I4l9qVRVFBCV2kM5G8eeqIasvbWTldpfT9Jd7ZHT2J7Hr2YeQs4YfGbAmi8gQFZCS_io5CcNQsy3I7JiquVVq1v-iqwOyBtyUsofAKhZLY_JccNkzXi9Ir_vH5A-TiGmIUQs9O4nVaypqY1-OWtQkm5SKVgK7TA-Jx_sM25mthrCX6TWjWEbxicaIp1rTrSbRhrTuHvYprfkdW-Hgu_29ZT8uv56f_W9urn99uPq8qZyAthYdZxz6aAWrVW6VUKDB6875RvrpVScYSfamstG9Zo1AnqUqucg284zK-blT8n5LneT0-OEZTTrUBwOg42YpmIUAw3Q1DMod6DL814Ze7PJYW3zk2FgFrFmsWYWa0ZJ8yLWLPnv9_lTt0Z_-LQ3Ofc_7Pu2ODv02UYXygHTrWASFuxih-HsYhswm-ICRoc-ZHSj8Sn8f45_GHmRFQ</recordid><startdate>19840309</startdate><enddate>19840309</enddate><creator>Keane, P.E.</creator><creator>Simiand, J.</creator><creator>Morre, M.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19840309</creationdate><title>The quinolines PK 8165 and PK 9084 possess benzodiazepine-like activity in vitro but not in vivo</title><author>Keane, P.E. ; Simiand, J. ; Morre, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c301t-b2224c0537a8978390d0d9b8d6ad44821eb3752468f91630fe48f2047bd1a3033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Animals</topic><topic>Anti-Anxiety Agents - pharmacology</topic><topic>anxiolytic</topic><topic>benzodiazepine receptor</topic><topic>Benzodiazepines - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Brain - metabolism</topic><topic>Diazepam - pharmacology</topic><topic>Flunitrazepam - metabolism</topic><topic>gamma-Aminobutyric Acid - biosynthesis</topic><topic>In Vitro Techniques</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>PK 8165</topic><topic>PK 9084</topic><topic>Psycholeptics: tranquillizer, neuroleptic</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>quinoline</topic><topic>Quinolines - pharmacology</topic><topic>Rats</topic><topic>Receptors, Cell Surface - metabolism</topic><topic>Receptors, GABA-A</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Keane, P.E.</creatorcontrib><creatorcontrib>Simiand, J.</creatorcontrib><creatorcontrib>Morre, M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Keane, P.E.</au><au>Simiand, J.</au><au>Morre, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The quinolines PK 8165 and PK 9084 possess benzodiazepine-like activity in vitro but not in vivo</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>1984-03-09</date><risdate>1984</risdate><volume>45</volume><issue>1</issue><spage>89</spage><epage>93</epage><pages>89-93</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>The quinolines PK 8165 and PK 9084 bind to brain benzodiazepine receptors in vitro. 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3H]flunitrazepam from benzodiazepine receptors in vivo. The pharmacological properties of PK 8165 and PK 9084 in vivo are thus unrelated to the benzodiazepine receptor.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>6145125</pmid><doi>10.1016/0304-3940(84)90334-3</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3940 |
| ispartof | Neuroscience letters, 1984-03, Vol.45 (1), p.89-93 |
| issn | 0304-3940 1872-7972 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_81090065 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Anti-Anxiety Agents - pharmacology anxiolytic benzodiazepine receptor Benzodiazepines - pharmacology Biological and medical sciences Brain - metabolism Diazepam - pharmacology Flunitrazepam - metabolism gamma-Aminobutyric Acid - biosynthesis In Vitro Techniques Medical sciences Mice Neuropharmacology Pharmacology. Drug treatments PK 8165 PK 9084 Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology quinoline Quinolines - pharmacology Rats Receptors, Cell Surface - metabolism Receptors, GABA-A |
| title | The quinolines PK 8165 and PK 9084 possess benzodiazepine-like activity in vitro but not in vivo |
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