The quinolines PK 8165 and PK 9084 possess benzodiazepine-like activity in vitro but not in vivo

The quinolines PK 8165 and PK 9084 bind to brain benzodiazepine receptors in vitro. However, unlike diazepam, these molecules do not reduce GABA turnover, possess anxiolytic properties, or displace [ 3H]flunitrazepam from benzodiazepine receptors in vivo. The pharmacological properties of PK 8165 an...

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Veröffentlicht in:	Neuroscience letters 1984-03, Vol.45 (1), p.89-93
Hauptverfasser:	Keane, P.E., Simiand, J., Morre, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Anxiety Agents - pharmacology anxiolytic benzodiazepine receptor Benzodiazepines - pharmacology Biological and medical sciences Brain - metabolism Diazepam - pharmacology Flunitrazepam - metabolism gamma-Aminobutyric Acid - biosynthesis In Vitro Techniques Medical sciences Mice Neuropharmacology Pharmacology. Drug treatments PK 8165 PK 9084 Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology quinoline Quinolines - pharmacology Rats Receptors, Cell Surface - metabolism Receptors, GABA-A
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Zusammenfassung:	The quinolines PK 8165 and PK 9084 bind to brain benzodiazepine receptors in vitro. However, unlike diazepam, these molecules do not reduce GABA turnover, possess anxiolytic properties, or displace [ 3H]flunitrazepam from benzodiazepine receptors in vivo. The pharmacological properties of PK 8165 and PK 9084 in vivo are thus unrelated to the benzodiazepine receptor.
ISSN:	0304-3940 1872-7972
DOI:	10.1016/0304-3940(84)90334-3