Analysis of Radioimmunodetection of Tumors by the Subtraction Technique
The subtraction method for radioimmunodetection (RID) of cancer is showing potential as a diagnostic tool. An objective assessment of this technique is needed in order to determine its clinical usefulness. A numerical analysis of the RID scintigrams was developed and applied to 21 RID studies on 20...
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| Veröffentlicht in: | The Journal of nuclear medicine (1978) 1984-01, Vol.25 (1), p.96-100 |
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| container_title | The Journal of nuclear medicine (1978) |
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| creator | Green, Alan J Begent, Richard H.J Keep, Patricia A Bagshawe, Kenneth D |
| description | The subtraction method for radioimmunodetection (RID) of cancer is showing potential as a diagnostic tool. An objective assessment of this technique is needed in order to determine its clinical usefulness. A numerical analysis of the RID scintigrams was developed and applied to 21 RID studies on 20 patients for whom a final diagnosis had been established. The subtraction technique was shown to give rise to artifactual positive regions, which could be avoided by experienced clinicians. When artifact-producing regions were excluded, 97 regions were examined (80 nontumor, 17 tumor-containing). The "background" scintigrams were shown to be good models for nontumor regions of the antibody scintigrams, and tumor and nontumor regions were shown to form statistically distinct groups. |
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An objective assessment of this technique is needed in order to determine its clinical usefulness. A numerical analysis of the RID scintigrams was developed and applied to 21 RID studies on 20 patients for whom a final diagnosis had been established. The subtraction technique was shown to give rise to artifactual positive regions, which could be avoided by experienced clinicians. When artifact-producing regions were excluded, 97 regions were examined (80 nontumor, 17 tumor-containing). 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An objective assessment of this technique is needed in order to determine its clinical usefulness. A numerical analysis of the RID scintigrams was developed and applied to 21 RID studies on 20 patients for whom a final diagnosis had been established. The subtraction technique was shown to give rise to artifactual positive regions, which could be avoided by experienced clinicians. When artifact-producing regions were excluded, 97 regions were examined (80 nontumor, 17 tumor-containing). The "background" scintigrams were shown to be good models for nontumor regions of the antibody scintigrams, and tumor and nontumor regions were shown to form statistically distinct groups.</abstract><cop>United States</cop><pub>Soc Nuclear Med</pub><pmid>6327943</pmid><tpages>5</tpages></addata></record> |
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| ispartof | The Journal of nuclear medicine (1978), 1984-01, Vol.25 (1), p.96-100 |
| issn | 0161-5505 1535-5667 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Antibodies Carcinoembryonic Antigen - immunology Humans Iodine Radioisotopes Neoplasms - diagnostic imaging Neoplasms - immunology Radionuclide Imaging Serum Albumin Sodium Pertechnetate Tc 99m Statistics as Topic Subtraction Technique Technetium Technetium Tc 99m Aggregated Albumin |
| title | Analysis of Radioimmunodetection of Tumors by the Subtraction Technique |
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