Purification, sequencing and synthesis of natriuretic and vasoactive rat atrial peptide

Mammalian atria contain potent natriuretic and diuretic substances 1,2 which exist in high- and low-molecular-weight forms 2,3 and which appear to be associated with atrium-specific granules 4 . The natriuretic effect of atrial extract is largely accountable for by its renal haemodynamic effects 5–7...

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Veröffentlicht in:	Nature (London) 1984-06, Vol.309 (5970), p.717-719
Hauptverfasser:	Atlas, S. A., Kleinert, H. D., Camargo, M. J., Januszewicz, A., Sealey, J. E., Laragh, J. H., Schilling, J. W., Lewicki, J. A., Johnson, L. K., Maack, T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Aminoacids, peptides. Hormones. Neuropeptides Analytical, structural and metabolic biochemistry Animals Aorta - drug effects Atrial Function Atrial Natriuretic Factor Biological and medical sciences Fundamental and applied biological sciences. Psychology Humanities and Social Sciences Kidney - drug effects Kidney - physiology letter Male multidisciplinary Muscle Contraction Muscle Proteins - chemical synthesis Muscle Proteins - isolation & purification Muscle Proteins - pharmacology Natriuresis - drug effects Natriuretic Agents Proteins Proteins - chemical synthesis Proteins - isolation & purification Proteins - pharmacology Rats Rats, Inbred Strains Science Science (multidisciplinary)
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