Increase in plasma lactate at the menopause and its relation to the “anion gap”
The mean plasma anion gap (Na + K + Ca + Mg)- (Cl + HCO 3 − + HPO 4 2 + protein), was significantly higher in post-menopausal women compared with pre-menopausal women (8.04 mEq/l compared with 7.03 mEq/1). This change was due, in part, to an increase in the plasma lactate concentration and to smalle...
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| Veröffentlicht in: | Maturitas 1984-03, Vol.5 (3), p.171-176 |
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| creator | Hodgkinson, A. Jones, M.M. Marshall, R.W. Skerrow, S.M. |
| description | The mean plasma anion gap (Na + K + Ca + Mg)- (Cl + HCO
3
− + HPO
4
2 + protein), was significantly higher in post-menopausal women compared with pre-menopausal women (8.04 mEq/l compared with 7.03 mEq/1). This change was due, in part, to an increase in the plasma lactate concentration and to smaller increases in citrate and pyruvate concentrations. There were also changes in bicarbonate and chloride concentrations which suggested an increase in pH of approximately 0.02 U. Together, these changes accounted for 46% of the increase in the “anion gap”, leaving 54% unexplained. It is suggested that the rise in plasma lactate concentration may be due to mild alkalosis and that this change may account for the rise in plasma urate concentration which also occurs at the menopause. |
| doi_str_mv | 10.1016/0378-5122(84)90049-5 |
| format | Article |
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3
− + HPO
4
2 + protein), was significantly higher in post-menopausal women compared with pre-menopausal women (8.04 mEq/l compared with 7.03 mEq/1). This change was due, in part, to an increase in the plasma lactate concentration and to smaller increases in citrate and pyruvate concentrations. There were also changes in bicarbonate and chloride concentrations which suggested an increase in pH of approximately 0.02 U. Together, these changes accounted for 46% of the increase in the “anion gap”, leaving 54% unexplained. It is suggested that the rise in plasma lactate concentration may be due to mild alkalosis and that this change may account for the rise in plasma urate concentration which also occurs at the menopause.</description><identifier>ISSN: 0378-5122</identifier><identifier>EISSN: 1873-4111</identifier><identifier>DOI: 10.1016/0378-5122(84)90049-5</identifier><identifier>PMID: 6727690</identifier><identifier>CODEN: MATUDK</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Acid-Base Equilibrium ; Adult ; Anion gap ; Biological and medical sciences ; Blood ; Blood Proteins - metabolism ; Citrate ; Citrates - blood ; Electrolytes - blood ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Hydrogen-Ion Concentration ; Lactate ; Lactates - blood ; Menopause ; Middle Aged ; Pyruvate ; Pyruvates - blood ; Sexual differentiation and maturation. Puberty. Climacterium ; Vertebrates: reproduction ; Women</subject><ispartof>Maturitas, 1984-03, Vol.5 (3), p.171-176</ispartof><rights>1984</rights><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-25651b770d5c5ec238c15c29dc30e34cd9ff6b5fc09ccaed3a0c3036f1e44b653</citedby><cites>FETCH-LOGICAL-c386t-25651b770d5c5ec238c15c29dc30e34cd9ff6b5fc09ccaed3a0c3036f1e44b653</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0378-5122(84)90049-5$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9633823$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6727690$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hodgkinson, A.</creatorcontrib><creatorcontrib>Jones, M.M.</creatorcontrib><creatorcontrib>Marshall, R.W.</creatorcontrib><creatorcontrib>Skerrow, S.M.</creatorcontrib><title>Increase in plasma lactate at the menopause and its relation to the “anion gap”</title><title>Maturitas</title><addtitle>Maturitas</addtitle><description>The mean plasma anion gap (Na + K + Ca + Mg)- (Cl + HCO
3
− + HPO
4
2 + protein), was significantly higher in post-menopausal women compared with pre-menopausal women (8.04 mEq/l compared with 7.03 mEq/1). This change was due, in part, to an increase in the plasma lactate concentration and to smaller increases in citrate and pyruvate concentrations. There were also changes in bicarbonate and chloride concentrations which suggested an increase in pH of approximately 0.02 U. Together, these changes accounted for 46% of the increase in the “anion gap”, leaving 54% unexplained. It is suggested that the rise in plasma lactate concentration may be due to mild alkalosis and that this change may account for the rise in plasma urate concentration which also occurs at the menopause.</description><subject>Acid-Base Equilibrium</subject><subject>Adult</subject><subject>Anion gap</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Blood Proteins - metabolism</subject><subject>Citrate</subject><subject>Citrates - blood</subject><subject>Electrolytes - blood</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Lactate</subject><subject>Lactates - blood</subject><subject>Menopause</subject><subject>Middle Aged</subject><subject>Pyruvate</subject><subject>Pyruvates - blood</subject><subject>Sexual differentiation and maturation. Puberty. Climacterium</subject><subject>Vertebrates: reproduction</subject><subject>Women</subject><issn>0378-5122</issn><issn>1873-4111</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM9u1DAQhy1EVZbCG4DkA0JwCNjxnziXSqgqUKkSB-BszU4mYJQ4wfYiceuDlJfrk5B0V3vsaTT6ffPT6GPshRTvpJD2vVCNq4ys6zdOv22F0G1lHrGNdI2qtJTyMdsckSfsac6_hBBGKH3KTm1TN7YVG_b1KmIiyMRD5PMAeQQ-ABYoxKHw8pP4SHGaYbcgEDseSuaJBihhirxM98TdzS3Edf8B893Nv2fspIch0_PDPGPfP15-u_hcXX_5dHXx4bpC5WypamON3DaN6Awawlo5lAbrtkMlSGns2r63W9OjaBGBOgViSZTtJWm9tUadsdf73jlNv3eUix9DRhoGiDTtsndSOGMbsYB6D2Kack7U-zmFEdJfL4VfXfpVlF9Feaf9vUu_9r889O-2I3XHo4O8JX91yCEjDH2CiCEfsdYq5Wq1YOd7jBYXfwIlnzFQROpCIiy-m8LDf_wH86uRWA</recordid><startdate>198403</startdate><enddate>198403</enddate><creator>Hodgkinson, A.</creator><creator>Jones, M.M.</creator><creator>Marshall, R.W.</creator><creator>Skerrow, S.M.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198403</creationdate><title>Increase in plasma lactate at the menopause and its relation to the “anion gap”</title><author>Hodgkinson, A. ; Jones, M.M. ; Marshall, R.W. ; Skerrow, S.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-25651b770d5c5ec238c15c29dc30e34cd9ff6b5fc09ccaed3a0c3036f1e44b653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Acid-Base Equilibrium</topic><topic>Adult</topic><topic>Anion gap</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>Blood Proteins - metabolism</topic><topic>Citrate</topic><topic>Citrates - blood</topic><topic>Electrolytes - blood</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>Lactate</topic><topic>Lactates - blood</topic><topic>Menopause</topic><topic>Middle Aged</topic><topic>Pyruvate</topic><topic>Pyruvates - blood</topic><topic>Sexual differentiation and maturation. Puberty. Climacterium</topic><topic>Vertebrates: reproduction</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hodgkinson, A.</creatorcontrib><creatorcontrib>Jones, M.M.</creatorcontrib><creatorcontrib>Marshall, R.W.</creatorcontrib><creatorcontrib>Skerrow, S.M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Maturitas</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hodgkinson, A.</au><au>Jones, M.M.</au><au>Marshall, R.W.</au><au>Skerrow, S.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increase in plasma lactate at the menopause and its relation to the “anion gap”</atitle><jtitle>Maturitas</jtitle><addtitle>Maturitas</addtitle><date>1984-03</date><risdate>1984</risdate><volume>5</volume><issue>3</issue><spage>171</spage><epage>176</epage><pages>171-176</pages><issn>0378-5122</issn><eissn>1873-4111</eissn><coden>MATUDK</coden><abstract>The mean plasma anion gap (Na + K + Ca + Mg)- (Cl + HCO
3
− + HPO
4
2 + protein), was significantly higher in post-menopausal women compared with pre-menopausal women (8.04 mEq/l compared with 7.03 mEq/1). This change was due, in part, to an increase in the plasma lactate concentration and to smaller increases in citrate and pyruvate concentrations. There were also changes in bicarbonate and chloride concentrations which suggested an increase in pH of approximately 0.02 U. Together, these changes accounted for 46% of the increase in the “anion gap”, leaving 54% unexplained. It is suggested that the rise in plasma lactate concentration may be due to mild alkalosis and that this change may account for the rise in plasma urate concentration which also occurs at the menopause.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>6727690</pmid><doi>10.1016/0378-5122(84)90049-5</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Maturitas, 1984-03, Vol.5 (3), p.171-176 |
| issn | 0378-5122 1873-4111 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Acid-Base Equilibrium Adult Anion gap Biological and medical sciences Blood Blood Proteins - metabolism Citrate Citrates - blood Electrolytes - blood Female Fundamental and applied biological sciences. Psychology Humans Hydrogen-Ion Concentration Lactate Lactates - blood Menopause Middle Aged Pyruvate Pyruvates - blood Sexual differentiation and maturation. Puberty. Climacterium Vertebrates: reproduction Women |
| title | Increase in plasma lactate at the menopause and its relation to the “anion gap” |
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