Cold-Recombinant Influenza A/California/10/78 (H1N1) Virus Vaccine (CR-37) in Seronegative Children: Infectivity and Efficacy Against Investigational Challenge

Forty-seven seronegative children were inoculated intranasally with influenza A/California/10/78 (HINl) cold-recombinant vaccine (CR-37). Doses ranged from 103.2 to 107.2 TCID50 per child. The dose necessary to infect 50% of children (one HID50) was ∼103.5 TCID50. Only two of eight children given 10...

Ausführliche Beschreibung