Absence of Duplication of Chromosome 21 Genes in Familial and Sporadic Alzheimer's Disease

The possibility that Alzheimer's disease (AD) is caused by overexpression or duplication of one or more genes on chromosome 21 has been raised by the observation of AD-like neuropathologic changes in individuals with Down syndrome and by the mapping of both the defect for familial AD and the am...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1987-10, Vol.238 (4827), p.664-666
Hauptverfasser:	St George-Hyslop, Peter H., Tanzi, Rudolph E., Polinsky, Ronald J., Neve, Rachael L., Pollen, Daniel, Drachman, David, Growdon, John, Cupples, L. Adrienne, Nee, Linda, Myers, Richard H., O'Sullivan, Dianne, Watkins, Paul C., Amos, Jean A., Deutsch, Curtis K., Bodfish, James W., Kinsbourne, Marcel, Feldman, Robert G., Bruni, Amalia, Amaducci, Luigi, Foncin, Jean-Francois, Gusella, James F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Alzheimer Disease - genetics Alzheimer's disease Amyloid - genetics Amyloids Biological and medical sciences Chromosomes Chromosomes, Human, Pair 21 Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases DNA DNA probes Gene dosage Genes Genetic aspects Genetic Linkage Genetic loci Genetics Human chromosome 21 Humans Leukocytes Medical genetics Medical research Medical schools Medical sciences Neurology Polymorphism, Restriction Fragment Length
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