Relative Lesion Detection Ability of Tc-99m HMDP and Tc-99m MDP: Concise Communication
To compare the efficacy of Tc-99m HMDP and Tc-99m MDP to define skeletal lesions, 28 adult patients were examined in a double-blind, randomized, crossover study. Each patient was imaged with both agents over a period of 7-14 days. Both quantitative and qualitative evaluations were performed on the r...
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| Veröffentlicht in: | The Journal of nuclear medicine (1978) 1984-02, Vol.25 (2), p.166-169 |
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| container_title | The Journal of nuclear medicine (1978) |
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| creator | Van Duzee, Barry F Schaefer, James A Ball, James D Chilton, Henry M Cowan, Robert J Kuni, Christopher Trow, Richard Watson, Nat E |
| description | To compare the efficacy of Tc-99m HMDP and Tc-99m MDP to define skeletal lesions, 28 adult patients were examined in a double-blind, randomized, crossover study. Each patient was imaged with both agents over a period of 7-14 days. Both quantitative and qualitative evaluations were performed on the resulting images. Both agents detected the same number of skeletal lesions, and the number of lesions detected was the same whether the imaging was performed 2 or 4 hr after injection. Relative uptake of the tracer in the lesion relative to normal bone was also the same for both agents. Lesions were easier to see at 4 hr after injection than at 2 hr, presumably because soft-tissue levels were lower. Retention of tracer in bone compared with soft tissue was greater, and image quality was judged to be better, with Tc-99m HMDP than with Tc-99m MDP. |
| format | Article |
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Each patient was imaged with both agents over a period of 7-14 days. Both quantitative and qualitative evaluations were performed on the resulting images. Both agents detected the same number of skeletal lesions, and the number of lesions detected was the same whether the imaging was performed 2 or 4 hr after injection. Relative uptake of the tracer in the lesion relative to normal bone was also the same for both agents. Lesions were easier to see at 4 hr after injection than at 2 hr, presumably because soft-tissue levels were lower. 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Each patient was imaged with both agents over a period of 7-14 days. Both quantitative and qualitative evaluations were performed on the resulting images. Both agents detected the same number of skeletal lesions, and the number of lesions detected was the same whether the imaging was performed 2 or 4 hr after injection. Relative uptake of the tracer in the lesion relative to normal bone was also the same for both agents. Lesions were easier to see at 4 hr after injection than at 2 hr, presumably because soft-tissue levels were lower. Retention of tracer in bone compared with soft tissue was greater, and image quality was judged to be better, with Tc-99m HMDP than with Tc-99m MDP.</description><subject>Adult</subject><subject>Bone and Bones - diagnostic imaging</subject><subject>Bone Neoplasms - diagnostic imaging</subject><subject>Bone Neoplasms - secondary</subject><subject>Clinical Trials as Topic</subject><subject>Diphosphonates</subject><subject>Double-Blind Method</subject><subject>Humans</subject><subject>Radionuclide Imaging</subject><subject>Technetium</subject><subject>Technetium Tc 99m Medronate</subject><subject>Time Factors</subject><issn>0161-5505</issn><issn>1535-5667</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkF1LwzAYhYMoc05_gpAr7wpJ81nvxqZOmCgyvQ1JmrqMJp1Nq-zf22HFq_MeeN4D55yAKWaEZYxzcQqmCHOcMYbYObhIaYcQ4lLKCZjwnBCK6BS8v7pad_7LwbVLvolw6Tpnu-M1N7723QE2FdzYrCgCXD0tX6CO5Z8f7C1cNNH65AYNoY_e6uPzJTirdJ3c1agz8HZ_t1mssvXzw-Nivs62ORFdlmsphCWCFgIXlaGYSI2oLlElhhqElJIx6jDNtSFW2lIUuJAGkZwaa8zQYQZufnP3bfPZu9Sp4JN1da2ja_qkJEaScFwM4PUI9ia4Uu1bH3R7UOMQ_0Fb_7H99q1Tsbe10-0R3sWQM5UrzDn5AT9YZPE</recordid><startdate>198402</startdate><enddate>198402</enddate><creator>Van Duzee, Barry F</creator><creator>Schaefer, James A</creator><creator>Ball, James D</creator><creator>Chilton, Henry M</creator><creator>Cowan, Robert J</creator><creator>Kuni, Christopher</creator><creator>Trow, Richard</creator><creator>Watson, Nat E</creator><general>Soc Nuclear Med</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>198402</creationdate><title>Relative Lesion Detection Ability of Tc-99m HMDP and Tc-99m MDP: Concise Communication</title><author>Van Duzee, Barry F ; Schaefer, James A ; Ball, James D ; Chilton, Henry M ; Cowan, Robert J ; Kuni, Christopher ; Trow, Richard ; Watson, Nat E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h237t-2a877c3749719fb4138a04ad0f715333d8554e142ab3c8cd79198b0324bcbb233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Adult</topic><topic>Bone and Bones - diagnostic imaging</topic><topic>Bone Neoplasms - diagnostic imaging</topic><topic>Bone Neoplasms - secondary</topic><topic>Clinical Trials as Topic</topic><topic>Diphosphonates</topic><topic>Double-Blind Method</topic><topic>Humans</topic><topic>Radionuclide Imaging</topic><topic>Technetium</topic><topic>Technetium Tc 99m Medronate</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Van Duzee, Barry F</creatorcontrib><creatorcontrib>Schaefer, James A</creatorcontrib><creatorcontrib>Ball, James D</creatorcontrib><creatorcontrib>Chilton, Henry M</creatorcontrib><creatorcontrib>Cowan, Robert J</creatorcontrib><creatorcontrib>Kuni, Christopher</creatorcontrib><creatorcontrib>Trow, Richard</creatorcontrib><creatorcontrib>Watson, Nat E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of nuclear medicine (1978)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Van Duzee, Barry F</au><au>Schaefer, James A</au><au>Ball, James D</au><au>Chilton, Henry M</au><au>Cowan, Robert J</au><au>Kuni, Christopher</au><au>Trow, Richard</au><au>Watson, Nat E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relative Lesion Detection Ability of Tc-99m HMDP and Tc-99m MDP: Concise Communication</atitle><jtitle>The Journal of nuclear medicine (1978)</jtitle><addtitle>J Nucl Med</addtitle><date>1984-02</date><risdate>1984</risdate><volume>25</volume><issue>2</issue><spage>166</spage><epage>169</epage><pages>166-169</pages><issn>0161-5505</issn><eissn>1535-5667</eissn><abstract>To compare the efficacy of Tc-99m HMDP and Tc-99m MDP to define skeletal lesions, 28 adult patients were examined in a double-blind, randomized, crossover study. Each patient was imaged with both agents over a period of 7-14 days. Both quantitative and qualitative evaluations were performed on the resulting images. Both agents detected the same number of skeletal lesions, and the number of lesions detected was the same whether the imaging was performed 2 or 4 hr after injection. Relative uptake of the tracer in the lesion relative to normal bone was also the same for both agents. Lesions were easier to see at 4 hr after injection than at 2 hr, presumably because soft-tissue levels were lower. Retention of tracer in bone compared with soft tissue was greater, and image quality was judged to be better, with Tc-99m HMDP than with Tc-99m MDP.</abstract><cop>United States</cop><pub>Soc Nuclear Med</pub><pmid>6233404</pmid><tpages>4</tpages></addata></record> |
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| ispartof | The Journal of nuclear medicine (1978), 1984-02, Vol.25 (2), p.166-169 |
| issn | 0161-5505 1535-5667 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Bone and Bones - diagnostic imaging Bone Neoplasms - diagnostic imaging Bone Neoplasms - secondary Clinical Trials as Topic Diphosphonates Double-Blind Method Humans Radionuclide Imaging Technetium Technetium Tc 99m Medronate Time Factors |
| title | Relative Lesion Detection Ability of Tc-99m HMDP and Tc-99m MDP: Concise Communication |
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