Dorsal raphe serotonergic projection to the retina. A combined peroxidase tracing-neurochemical/high-performance liquid chromatography study in the rat
The existence of retinopetal neurons in the rat was verified using a morphological and neurochemical approach. Horseradish peroxidase injected into the posterior chamber of the eye labeled polygonal, ovoid, fusiform and small multipolar neurons in the lateral cell groups of the dorsal raphe nucleus....
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| Veröffentlicht in: | Neuroscience 1987, Vol.22 (2), p.681-686 |
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| container_title | Neuroscience |
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| creator | Villar, M.J. Vitale, M.L. Parisi, M.N. |
| description | The existence of retinopetal neurons in the rat was verified using a morphological and neurochemical approach. Horseradish peroxidase injected into the posterior chamber of the eye labeled polygonal, ovoid, fusiform and small multipolar neurons in the lateral cell groups of the dorsal raphe nucleus. Very small electrolytic lesions of this region produced after several days of survival a significant decrease in the serotonin content of the retina.
These results demonstrate the existence of a centrifugal projection to the retina from the lateral cell groups of the dorsal raphe nucleus and show its probable serotonergic nature. Besides, they also provide a new possibility to explain the presence of serotonin in the retina. |
| doi_str_mv | 10.1016/0306-4522(87)90364-2 |
| format | Article |
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These results demonstrate the existence of a centrifugal projection to the retina from the lateral cell groups of the dorsal raphe nucleus and show its probable serotonergic nature. Besides, they also provide a new possibility to explain the presence of serotonin in the retina.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Eye and associated structures. Visual pathways and centers. Vision</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Horseradish Peroxidase</subject><subject>Male</subject><subject>Neurochemistry</subject><subject>Neurons - cytology</subject><subject>Raphe Nuclei - cytology</subject><subject>Raphe Nuclei - physiology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Retina - physiology</subject><subject>Serotonin - physiology</subject><subject>Synaptic Transmission</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0306-4522</issn><issn>1873-7544</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUctu1DAUtRCoDIU_AMkLhMoire04trOpVLW8pEpsYG059s3EVRJPbQcxX8Lv4nRGswRvvDiPe-85CL2l5JISKq5ITUTFG8YulPzYklrwij1DG6pkXcmG8-doc6K8RK9SeiDlNbw-Q2dMsZrKdoP-3IWYzIij2Q2AE8SQwwxx6y3exfAANvsw4xxwLnCE7GdziW-wDVPnZ3B4VxS_vTMJcI7G-nlbzbDEYAeYvDXj1eC3Q1VYfYiTmS3g0T8u3mE7xDCZHLbr5D1OeXF77OfDHJNfoxe9GRO8Of7n6OfnTz9uv1b33798u725r2xDWa5q2XSqaY2BtrN9pwx0QggpuGCmbnsFljWSupZwagW4viNcNoS11jW9sq2qz9GHg2-59nGBlPXkk4VxNDOEJWlFiWKUiP8SKVdUErE68gPRxpBShF7vop9M3GtK9FqcXlvRaytaSf1UnGZF9u7ov3QTuJPo2FTB3x9xk0qufSxh-nSiSS4Ef1rz-kCDEtovD1En66Hk7nwsZWoX_L_3-Av1HrfE</recordid><startdate>1987</startdate><enddate>1987</enddate><creator>Villar, M.J.</creator><creator>Vitale, M.L.</creator><creator>Parisi, M.N.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>1987</creationdate><title>Dorsal raphe serotonergic projection to the retina. 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Psychology</topic><topic>Horseradish Peroxidase</topic><topic>Male</topic><topic>Neurochemistry</topic><topic>Neurons - cytology</topic><topic>Raphe Nuclei - cytology</topic><topic>Raphe Nuclei - physiology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Retina - physiology</topic><topic>Serotonin - physiology</topic><topic>Synaptic Transmission</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Villar, M.J.</creatorcontrib><creatorcontrib>Vitale, M.L.</creatorcontrib><creatorcontrib>Parisi, M.N.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Villar, M.J.</au><au>Vitale, M.L.</au><au>Parisi, M.N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dorsal raphe serotonergic projection to the retina. A combined peroxidase tracing-neurochemical/high-performance liquid chromatography study in the rat</atitle><jtitle>Neuroscience</jtitle><addtitle>Neuroscience</addtitle><date>1987</date><risdate>1987</risdate><volume>22</volume><issue>2</issue><spage>681</spage><epage>686</epage><pages>681-686</pages><issn>0306-4522</issn><eissn>1873-7544</eissn><coden>NRSCDN</coden><abstract>The existence of retinopetal neurons in the rat was verified using a morphological and neurochemical approach. Horseradish peroxidase injected into the posterior chamber of the eye labeled polygonal, ovoid, fusiform and small multipolar neurons in the lateral cell groups of the dorsal raphe nucleus. Very small electrolytic lesions of this region produced after several days of survival a significant decrease in the serotonin content of the retina.
These results demonstrate the existence of a centrifugal projection to the retina from the lateral cell groups of the dorsal raphe nucleus and show its probable serotonergic nature. Besides, they also provide a new possibility to explain the presence of serotonin in the retina.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>2823179</pmid><doi>10.1016/0306-4522(87)90364-2</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0306-4522 |
| ispartof | Neuroscience, 1987, Vol.22 (2), p.681-686 |
| issn | 0306-4522 1873-7544 |
| language | eng |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Animals Biological and medical sciences Chromatography, High Pressure Liquid Eye and associated structures. Visual pathways and centers. Vision Fundamental and applied biological sciences. Psychology Horseradish Peroxidase Male Neurochemistry Neurons - cytology Raphe Nuclei - cytology Raphe Nuclei - physiology Rats Rats, Inbred Strains Retina - physiology Serotonin - physiology Synaptic Transmission Vertebrates: nervous system and sense organs |
| title | Dorsal raphe serotonergic projection to the retina. A combined peroxidase tracing-neurochemical/high-performance liquid chromatography study in the rat |
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