Self-Regulation of Phosphate Intake in the Rat: The Influence of Age, Vitamin D and Parathyroid Hormone
Growing rats offered a choice of four pairs of diets, one low in P (0.1%) and the others containing 0.3, 0.6, 1.2 or 1.8% P, selected food mixtures in each case with nearly identical P contents (0.23–0.24%) (Ca:P = 2.2:1). Mature rats offered the same dietary choices exhibited less rigid diet select...
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| Veröffentlicht in: | The Journal of nutrition 1984-06, Vol.114 (6), p.1097-1105 |
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| creator | Siu, G.M. Hadley, M. Agwu, D.E. Draper, H.H. |
| description | Growing rats offered a choice of four pairs of diets, one low in P (0.1%) and the others containing 0.3, 0.6, 1.2 or 1.8% P, selected food mixtures in each case with nearly identical P contents (0.23–0.24%) (Ca:P = 2.2:1). Mature rats offered the same dietary choices exhibited less rigid diet selection but clearly preferred a diet higher in P (0.64–0.69%) (Ca:P = 0.9:1). Vitamin D-deficient animals selected less P than controls and parathyroidectomized rats severely limited their P intake. The increase in self-determined P consumption relative to Ca in mature rats is consonant with the greater decrease in the requirement for Ca associated with maturation and cessation of bone growth. Susceptibility to hypocalcemia in vitamin D deficiency and parathyroidectomy is a probable factor in the increased sensitivity to excess dietary P, which further depresses plasma Ca. These experiments confirm the existence of a feedback mechanism that regulates the voluntary consumption of P in accordance with physiological needs. |
| doi_str_mv | 10.1093/jn/114.6.1097 |
| format | Article |
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Mature rats offered the same dietary choices exhibited less rigid diet selection but clearly preferred a diet higher in P (0.64–0.69%) (Ca:P = 0.9:1). Vitamin D-deficient animals selected less P than controls and parathyroidectomized rats severely limited their P intake. The increase in self-determined P consumption relative to Ca in mature rats is consonant with the greater decrease in the requirement for Ca associated with maturation and cessation of bone growth. Susceptibility to hypocalcemia in vitamin D deficiency and parathyroidectomy is a probable factor in the increased sensitivity to excess dietary P, which further depresses plasma Ca. These experiments confirm the existence of a feedback mechanism that regulates the voluntary consumption of P in accordance with physiological needs.</description><identifier>ISSN: 0022-3166</identifier><identifier>EISSN: 1541-6100</identifier><identifier>DOI: 10.1093/jn/114.6.1097</identifier><identifier>PMID: 6726472</identifier><identifier>CODEN: JONUAI</identifier><language>eng</language><publisher>Bethesda, MD: Elsevier Inc</publisher><subject>Aging ; Animals ; Biological and medical sciences ; calcium ; Calcium - blood ; Diet ; Feedback ; Feeding Behavior - physiology ; Female ; Fundamental and applied biological sciences. Psychology ; Hormones. Regulation ; human nutrition ; Male ; nutrition physiology ; Parathyroid Glands - physiology ; parathyroid hormone ; Parathyroid Hormone - physiology ; Phosphates - administration & dosage ; phosphorus ; Phosphorus - blood ; Rats ; Rats, Inbred Strains ; Thyroid. Parathyroid. Ultimobranchial body ; Vertebrates: endocrinology ; vitamin D ; Vitamin D - physiology</subject><ispartof>The Journal of nutrition, 1984-06, Vol.114 (6), p.1097-1105</ispartof><rights>1984 American Society Nutrition.</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c525t-773193ee9ea16d2f3f262d54be3cffeb825168f784cbbeab901dbbb1357b1a023</citedby><cites>FETCH-LOGICAL-c525t-773193ee9ea16d2f3f262d54be3cffeb825168f784cbbeab901dbbb1357b1a023</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8997240$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6726472$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Siu, G.M.</creatorcontrib><creatorcontrib>Hadley, M.</creatorcontrib><creatorcontrib>Agwu, D.E.</creatorcontrib><creatorcontrib>Draper, H.H.</creatorcontrib><title>Self-Regulation of Phosphate Intake in the Rat: The Influence of Age, Vitamin D and Parathyroid Hormone</title><title>The Journal of nutrition</title><addtitle>J Nutr</addtitle><description>Growing rats offered a choice of four pairs of diets, one low in P (0.1%) and the others containing 0.3, 0.6, 1.2 or 1.8% P, selected food mixtures in each case with nearly identical P contents (0.23–0.24%) (Ca:P = 2.2:1). Mature rats offered the same dietary choices exhibited less rigid diet selection but clearly preferred a diet higher in P (0.64–0.69%) (Ca:P = 0.9:1). Vitamin D-deficient animals selected less P than controls and parathyroidectomized rats severely limited their P intake. The increase in self-determined P consumption relative to Ca in mature rats is consonant with the greater decrease in the requirement for Ca associated with maturation and cessation of bone growth. Susceptibility to hypocalcemia in vitamin D deficiency and parathyroidectomy is a probable factor in the increased sensitivity to excess dietary P, which further depresses plasma Ca. These experiments confirm the existence of a feedback mechanism that regulates the voluntary consumption of P in accordance with physiological needs.</description><subject>Aging</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>calcium</subject><subject>Calcium - blood</subject><subject>Diet</subject><subject>Feedback</subject><subject>Feeding Behavior - physiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hormones. Regulation</subject><subject>human nutrition</subject><subject>Male</subject><subject>nutrition physiology</subject><subject>Parathyroid Glands - physiology</subject><subject>parathyroid hormone</subject><subject>Parathyroid Hormone - physiology</subject><subject>Phosphates - administration & dosage</subject><subject>phosphorus</subject><subject>Phosphorus - blood</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Thyroid. Parathyroid. Ultimobranchial body</subject><subject>Vertebrates: endocrinology</subject><subject>vitamin D</subject><subject>Vitamin D - physiology</subject><issn>0022-3166</issn><issn>1541-6100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0U1v1DAQBmALgcpSOHJE-IB6Iq3HSWyHW9UCrVSJqh9cLdsZb7xk48VOkPrvSbSr3hAnazyPRqN3CHkP7BRYU55thjOA6lQslXxBVlBXUAhg7CVZMcZ5UYIQr8mbnDeMMagadUSOhOSiknxF1vfY--IO11NvxhAHGj297WLedWZEej2M5hfSMNCxQ3pnxi_0oVu-fT_h4HDR52v8TH-G0WxndknN0NJbk8zYPaUYWnoV0zYO-Ja88qbP-O7wHpPHb18fLq6Kmx_fry_ObwpX83ospCyhKREbNCBa7kvPBW_rymLpvEereA1CeakqZy0a2zBorbVQ1tKCYbw8Jif7ubsUf0-YR70N2WHfmwHjlLUCpkBJ9V8IFSzxwgyLPXQp5pzQ610KW5OeNDC9EL0Z9HwBLZZKzv7DYfBkt9g-60Pkc__ToW-yM71PZnAhPzPVNJJXbGYf98ybqM06zeTxnjMoGa8rxUQzC7kXOOf5J2DS2YXlKm1I6EbdxvCPFf8CP_-o7Q</recordid><startdate>198406</startdate><enddate>198406</enddate><creator>Siu, G.M.</creator><creator>Hadley, M.</creator><creator>Agwu, D.E.</creator><creator>Draper, H.H.</creator><general>Elsevier Inc</general><general>American Society for Nutritional Sciences</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>198406</creationdate><title>Self-Regulation of Phosphate Intake in the Rat: The Influence of Age, Vitamin D and Parathyroid Hormone</title><author>Siu, G.M. ; Hadley, M. ; Agwu, D.E. ; Draper, H.H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c525t-773193ee9ea16d2f3f262d54be3cffeb825168f784cbbeab901dbbb1357b1a023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Aging</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>calcium</topic><topic>Calcium - blood</topic><topic>Diet</topic><topic>Feedback</topic><topic>Feeding Behavior - physiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hormones. Regulation</topic><topic>human nutrition</topic><topic>Male</topic><topic>nutrition physiology</topic><topic>Parathyroid Glands - physiology</topic><topic>parathyroid hormone</topic><topic>Parathyroid Hormone - physiology</topic><topic>Phosphates - administration & dosage</topic><topic>phosphorus</topic><topic>Phosphorus - blood</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Thyroid. Parathyroid. Ultimobranchial body</topic><topic>Vertebrates: endocrinology</topic><topic>vitamin D</topic><topic>Vitamin D - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Siu, G.M.</creatorcontrib><creatorcontrib>Hadley, M.</creatorcontrib><creatorcontrib>Agwu, D.E.</creatorcontrib><creatorcontrib>Draper, H.H.</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Siu, G.M.</au><au>Hadley, M.</au><au>Agwu, D.E.</au><au>Draper, H.H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Self-Regulation of Phosphate Intake in the Rat: The Influence of Age, Vitamin D and Parathyroid Hormone</atitle><jtitle>The Journal of nutrition</jtitle><addtitle>J Nutr</addtitle><date>1984-06</date><risdate>1984</risdate><volume>114</volume><issue>6</issue><spage>1097</spage><epage>1105</epage><pages>1097-1105</pages><issn>0022-3166</issn><eissn>1541-6100</eissn><coden>JONUAI</coden><abstract>Growing rats offered a choice of four pairs of diets, one low in P (0.1%) and the others containing 0.3, 0.6, 1.2 or 1.8% P, selected food mixtures in each case with nearly identical P contents (0.23–0.24%) (Ca:P = 2.2:1). Mature rats offered the same dietary choices exhibited less rigid diet selection but clearly preferred a diet higher in P (0.64–0.69%) (Ca:P = 0.9:1). Vitamin D-deficient animals selected less P than controls and parathyroidectomized rats severely limited their P intake. The increase in self-determined P consumption relative to Ca in mature rats is consonant with the greater decrease in the requirement for Ca associated with maturation and cessation of bone growth. Susceptibility to hypocalcemia in vitamin D deficiency and parathyroidectomy is a probable factor in the increased sensitivity to excess dietary P, which further depresses plasma Ca. These experiments confirm the existence of a feedback mechanism that regulates the voluntary consumption of P in accordance with physiological needs.</abstract><cop>Bethesda, MD</cop><pub>Elsevier Inc</pub><pmid>6726472</pmid><doi>10.1093/jn/114.6.1097</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of nutrition, 1984-06, Vol.114 (6), p.1097-1105 |
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| subjects | Aging Animals Biological and medical sciences calcium Calcium - blood Diet Feedback Feeding Behavior - physiology Female Fundamental and applied biological sciences. Psychology Hormones. Regulation human nutrition Male nutrition physiology Parathyroid Glands - physiology parathyroid hormone Parathyroid Hormone - physiology Phosphates - administration & dosage phosphorus Phosphorus - blood Rats Rats, Inbred Strains Thyroid. Parathyroid. Ultimobranchial body Vertebrates: endocrinology vitamin D Vitamin D - physiology |
| title | Self-Regulation of Phosphate Intake in the Rat: The Influence of Age, Vitamin D and Parathyroid Hormone |
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