Use of hexadeuterated valproic acid and gas chromatography-mass spectrometry to determine the pharmacokinetics of valproic acid

Di‐([3,3,3−2H3]propyl)acetic acid, a hexadeuterated analogue of valproic acid, was synthesized and its pharmacokinetic properties compared with valproic acid. Concentrations of valproic acid and [2H]valproic acid in serum and saliva were determined by GC‐MS using selected‐ion monitoring. Saliva drug...

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Veröffentlicht in:	J. Pharm. Sci.; (United States) 1984-04, Vol.73 (4), p.489-494
Hauptverfasser:	Acheampong, Andrew A., Abbott, Frank S., Orr, James M., Ferguson, Sheila M., Burton, Roland W.
Format:	Artikel
Sprache:	eng
Schlagworte:	400702 - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials 550601 - Medicine- Unsealed Radionuclides in Diagnostics Adult analogue ANTICONVULSANTS Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences BIOLOGICAL MATERIALS Blood Proteins - metabolism BLOOD SERUM BODY FLUIDS CENTRAL NERVOUS SYSTEM DEPRESSANTS CHEMICAL PROPERTIES CHROMATOGRAPHY Deuterium DEUTERIUM COMPOUNDS DRUGS GAS CHROMATOGRAPHY Gas Chromatography-Mass Spectrometry hexadeuterated Humans HYDROGEN COMPOUNDS ISOTOPE APPLICATIONS Isotope Labeling - methods KINETICS LABELLED COMPOUNDS Male MASS SPECTROSCOPY MATERIALS Medical sciences Neuropharmacology PATIENTS pharmacokinetics single- and multiple-dose regimes Pharmacokinetics-valproic acid Pharmacokinetics—valproic acid, hexadeuterated, analogue, single‐ and multiple‐dose regimens, gas chromatography‐mass spectrometry PHARMACOLOGY Pharmacology. Drug treatments Protein Binding RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY RADIOLOGY AND NUCLEAR MEDICINE RADIOPHARMACEUTICALS SALIVA Saliva - analysis SEPARATION PROCESSES single- and multiple-dose regimens SPECTROSCOPY Time Factors TRACER TECHNIQUES Valproic Acid - metabolism Valproic acid-hexadeuterated analogue Valproic acid—hexadeuterated analogue, gas chromatography‐mass spectrometry, pharmacokinetics single‐ and multiple‐dose regimes
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