Immunohistochemical localization of apolipoproteins A-I and B in human carotid arteries
Decreased plasma levels of apolipoprotein A–I (apo A–I) and increased plasma levels of apolipoprotein B (apo B) have been shown to correlate with increased risk of atherosclerosis. While many studies have investigated the plasma levels of these apolipoproteins with regard to their value as predictor...
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| Veröffentlicht in: | The Journal of pathology 1987-09, Vol.153 (1), p.31-36 |
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| container_title | The Journal of pathology |
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| creator | Carter, Richard S. Siegel, Robert J. Chai, Andrew U. Fishbein, Michael C. |
| description | Decreased plasma levels of apolipoprotein A–I (apo A–I) and increased plasma levels of apolipoprotein B (apo B) have been shown to correlate with increased risk of atherosclerosis. While many studies have investigated the plasma levels of these apolipoproteins with regard to their value as predictors of cardiovascular disease, comparatively little is known about their precise tissue localization in atherosclerotic plaques. The purpose of this study was to determine the tissue localization of apo A–I and apo B in atherosclerotic segments of human carotid arteries through the use of immunohistochemical techniques. With tissue samples obtained from surgery and autopsy, apo A–I and apo B were found to be present in atherosclerotic plaques and absent in normal arterial tissue. In the plaques, both apo A–I and apo B were found extracellularly, primarily in the lipid core, but also in connective tissue. In addition, both apo A–I and apo B were found intracellularly in foam cells. This similar intracellular and extracellular distribution of apo A–I and apo B was unexpected, in view of their differing associations with atherosclerosis. |
| doi_str_mv | 10.1002/path.1711530105 |
| format | Article |
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While many studies have investigated the plasma levels of these apolipoproteins with regard to their value as predictors of cardiovascular disease, comparatively little is known about their precise tissue localization in atherosclerotic plaques. The purpose of this study was to determine the tissue localization of apo A–I and apo B in atherosclerotic segments of human carotid arteries through the use of immunohistochemical techniques. With tissue samples obtained from surgery and autopsy, apo A–I and apo B were found to be present in atherosclerotic plaques and absent in normal arterial tissue. In the plaques, both apo A–I and apo B were found extracellularly, primarily in the lipid core, but also in connective tissue. In addition, both apo A–I and apo B were found intracellularly in foam cells. This similar intracellular and extracellular distribution of apo A–I and apo B was unexpected, in view of their differing associations with atherosclerosis.</description><identifier>ISSN: 0022-3417</identifier><identifier>EISSN: 1096-9896</identifier><identifier>DOI: 10.1002/path.1711530105</identifier><identifier>PMID: 3117995</identifier><identifier>CODEN: JPTLAS</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>APO A-I ; APO B ; Apolipoprotein A-I ; apolipoproteins ; Apolipoproteins A - metabolism ; Apolipoproteins B - metabolism ; arteries ; Arteriosclerosis - metabolism ; Biological and medical sciences ; Carotid Arteries - metabolism ; Connective Tissue - metabolism ; Foam Cells - metabolism ; Humans ; Immunoenzyme Techniques ; Immunohistochemistry ; Lipoproteins, HDL - metabolism ; Medical sciences ; Neurology ; Vascular diseases and vascular malformations of the nervous system</subject><ispartof>The Journal of pathology, 1987-09, Vol.153 (1), p.31-36</ispartof><rights>Copyright © 1987 John Wiley & Sons, Ltd.</rights><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3265-93d7dd2c0e9c77017d6918636408897ca431579e74dddd682c23ef4e497c058d3</citedby><cites>FETCH-LOGICAL-c3265-93d7dd2c0e9c77017d6918636408897ca431579e74dddd682c23ef4e497c058d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpath.1711530105$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpath.1711530105$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,27907,27908,45557,45558</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7718669$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3117995$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carter, Richard S.</creatorcontrib><creatorcontrib>Siegel, Robert J.</creatorcontrib><creatorcontrib>Chai, Andrew U.</creatorcontrib><creatorcontrib>Fishbein, Michael C.</creatorcontrib><title>Immunohistochemical localization of apolipoproteins A-I and B in human carotid arteries</title><title>The Journal of pathology</title><addtitle>J. Pathol</addtitle><description>Decreased plasma levels of apolipoprotein A–I (apo A–I) and increased plasma levels of apolipoprotein B (apo B) have been shown to correlate with increased risk of atherosclerosis. While many studies have investigated the plasma levels of these apolipoproteins with regard to their value as predictors of cardiovascular disease, comparatively little is known about their precise tissue localization in atherosclerotic plaques. The purpose of this study was to determine the tissue localization of apo A–I and apo B in atherosclerotic segments of human carotid arteries through the use of immunohistochemical techniques. With tissue samples obtained from surgery and autopsy, apo A–I and apo B were found to be present in atherosclerotic plaques and absent in normal arterial tissue. In the plaques, both apo A–I and apo B were found extracellularly, primarily in the lipid core, but also in connective tissue. In addition, both apo A–I and apo B were found intracellularly in foam cells. This similar intracellular and extracellular distribution of apo A–I and apo B was unexpected, in view of their differing associations with atherosclerosis.</description><subject>APO A-I</subject><subject>APO B</subject><subject>Apolipoprotein A-I</subject><subject>apolipoproteins</subject><subject>Apolipoproteins A - metabolism</subject><subject>Apolipoproteins B - metabolism</subject><subject>arteries</subject><subject>Arteriosclerosis - metabolism</subject><subject>Biological and medical sciences</subject><subject>Carotid Arteries - metabolism</subject><subject>Connective Tissue - metabolism</subject><subject>Foam Cells - metabolism</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Immunohistochemistry</subject><subject>Lipoproteins, HDL - metabolism</subject><subject>Medical sciences</subject><subject>Neurology</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><issn>0022-3417</issn><issn>1096-9896</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1PwyAYxonR6Pw4ezLhYLzVQWmhxNNc_JjRaeKMR4JAM7QtFdr48dfLsmXGkxyA5Pk9L-_7AMAhRqcYoXTYym5-ihnGOUEY5RtggBGnCS843QSDSKQJyTDbAbshvCKEOM_zbbBNMGbxOgDPk7ruGze3oXNqbmqrZAUrF3f7LTvrGuhKKFtX2da13nXGNgGOkgmUjYbn0DZw3teygUpG0WoofWe8NWEfbJWyCuZgde6Bp8uL2fg6ub2_moxHt4kiKc0TTjTTOlXIcMUYwkxTjgtKaIaKgjMlM4Jzxg3LdFy0SFVKTJmZLGooLzTZAyfLurG5996ETtQ2KFNVsjGuD6LAKA6KSASHS1B5F4I3pWi9raX_EhiJRZRiEaX4jTI6jlal-5fa6DW_yi7qxytdhphX6WWjbFhjjMVBKI_Y2RL7sJX5-u9V8TCaXf9pIlm64weZz7Vb-jdBGWG5eJ5eibvsZvZYTKeCkR_IipyG</recordid><startdate>198709</startdate><enddate>198709</enddate><creator>Carter, Richard S.</creator><creator>Siegel, Robert J.</creator><creator>Chai, Andrew U.</creator><creator>Fishbein, Michael C.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198709</creationdate><title>Immunohistochemical localization of apolipoproteins A-I and B in human carotid arteries</title><author>Carter, Richard S. ; Siegel, Robert J. ; Chai, Andrew U. ; Fishbein, Michael C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3265-93d7dd2c0e9c77017d6918636408897ca431579e74dddd682c23ef4e497c058d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>APO A-I</topic><topic>APO B</topic><topic>Apolipoprotein A-I</topic><topic>apolipoproteins</topic><topic>Apolipoproteins A - metabolism</topic><topic>Apolipoproteins B - metabolism</topic><topic>arteries</topic><topic>Arteriosclerosis - metabolism</topic><topic>Biological and medical sciences</topic><topic>Carotid Arteries - metabolism</topic><topic>Connective Tissue - metabolism</topic><topic>Foam Cells - metabolism</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>Immunohistochemistry</topic><topic>Lipoproteins, HDL - metabolism</topic><topic>Medical sciences</topic><topic>Neurology</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carter, Richard S.</creatorcontrib><creatorcontrib>Siegel, Robert J.</creatorcontrib><creatorcontrib>Chai, Andrew U.</creatorcontrib><creatorcontrib>Fishbein, Michael C.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carter, Richard S.</au><au>Siegel, Robert J.</au><au>Chai, Andrew U.</au><au>Fishbein, Michael C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunohistochemical localization of apolipoproteins A-I and B in human carotid arteries</atitle><jtitle>The Journal of pathology</jtitle><addtitle>J. Pathol</addtitle><date>1987-09</date><risdate>1987</risdate><volume>153</volume><issue>1</issue><spage>31</spage><epage>36</epage><pages>31-36</pages><issn>0022-3417</issn><eissn>1096-9896</eissn><coden>JPTLAS</coden><abstract>Decreased plasma levels of apolipoprotein A–I (apo A–I) and increased plasma levels of apolipoprotein B (apo B) have been shown to correlate with increased risk of atherosclerosis. While many studies have investigated the plasma levels of these apolipoproteins with regard to their value as predictors of cardiovascular disease, comparatively little is known about their precise tissue localization in atherosclerotic plaques. The purpose of this study was to determine the tissue localization of apo A–I and apo B in atherosclerotic segments of human carotid arteries through the use of immunohistochemical techniques. With tissue samples obtained from surgery and autopsy, apo A–I and apo B were found to be present in atherosclerotic plaques and absent in normal arterial tissue. In the plaques, both apo A–I and apo B were found extracellularly, primarily in the lipid core, but also in connective tissue. In addition, both apo A–I and apo B were found intracellularly in foam cells. This similar intracellular and extracellular distribution of apo A–I and apo B was unexpected, in view of their differing associations with atherosclerosis.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>3117995</pmid><doi>10.1002/path.1711530105</doi><tpages>6</tpages></addata></record> |
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| ispartof | The Journal of pathology, 1987-09, Vol.153 (1), p.31-36 |
| issn | 0022-3417 1096-9896 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | APO A-I APO B Apolipoprotein A-I apolipoproteins Apolipoproteins A - metabolism Apolipoproteins B - metabolism arteries Arteriosclerosis - metabolism Biological and medical sciences Carotid Arteries - metabolism Connective Tissue - metabolism Foam Cells - metabolism Humans Immunoenzyme Techniques Immunohistochemistry Lipoproteins, HDL - metabolism Medical sciences Neurology Vascular diseases and vascular malformations of the nervous system |
| title | Immunohistochemical localization of apolipoproteins A-I and B in human carotid arteries |
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