Immunopathology of pityriasis lichenoides acuta
Eleven biopsy specimens (five papules and six dusky or crusted lesions) from four patients with pityriasis lichenoides et varioliformis acuta (PLEVA) were studied by direct immunofluorescence and immunoperoxidase technics. Slight vascular deposits of IgM and C3 were present in most lesions. Slight p...
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| Veröffentlicht in: | Journal of the American Academy of Dermatology 1984-05, Vol.10 (5), p.783-795 |
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| creator | Muhlbauer, Jan E. Bhan, Atul K. Harrist, Terence J. Moscicki, Richard A. Rand, Rhonda Caughman, Wright Loss, Bob Mihm, Martin C. |
| description | Eleven biopsy specimens (five papules and six dusky or crusted lesions) from four patients with pityriasis lichenoides et varioliformis acuta (PLEVA) were studied by direct immunofluorescence and immunoperoxidase technics. Slight vascular deposits of IgM and C3 were present in most lesions. Slight perivascular deposits of fibrin were observed in early lesions; more extensive perivascular and interstitial deposits of fibrin were detected in advanced lesions. Most of the infiltrating cells were T lymphocytes; cells with cytotoxic/suppressor phenotype (T8-positive) were generally more numerous than cells with helper/inducer phenotype (Leu-3a-positive, T4-positive). A marked increase in epidermal T8-positive cells over epidermal Leu-3a/T4-positive cells was found in late lesions. Moreover, a reduction of the ratio of circulating T4-positive to T8-positive cells was observed in most cases. The number of epidermal To-positive (Langerhans/indeterminate) cells was decreased in the lower as compared with the upper stratum spinosum. About 5% of perivascular infiltrating cells were T6-positive. These results suggest that cell-mediated immune mechanisms are probably important in the pathogenesis of PLEVA. |
| doi_str_mv | 10.1016/S0190-9622(84)70094-6 |
| format | Article |
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Slight vascular deposits of IgM and C3 were present in most lesions. Slight perivascular deposits of fibrin were observed in early lesions; more extensive perivascular and interstitial deposits of fibrin were detected in advanced lesions. Most of the infiltrating cells were T lymphocytes; cells with cytotoxic/suppressor phenotype (T8-positive) were generally more numerous than cells with helper/inducer phenotype (Leu-3a-positive, T4-positive). A marked increase in epidermal T8-positive cells over epidermal Leu-3a/T4-positive cells was found in late lesions. Moreover, a reduction of the ratio of circulating T4-positive to T8-positive cells was observed in most cases. The number of epidermal To-positive (Langerhans/indeterminate) cells was decreased in the lower as compared with the upper stratum spinosum. About 5% of perivascular infiltrating cells were T6-positive. These results suggest that cell-mediated immune mechanisms are probably important in the pathogenesis of PLEVA.</description><identifier>ISSN: 0190-9622</identifier><identifier>EISSN: 1097-6787</identifier><identifier>DOI: 10.1016/S0190-9622(84)70094-6</identifier><identifier>PMID: 6373855</identifier><identifier>CODEN: JAADDB</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adult ; Antibodies, Monoclonal - immunology ; Biological and medical sciences ; Complement C3 - analysis ; Dermatology ; Female ; Fibrin - analysis ; Flow Cytometry ; Fluorescent Antibody Technique ; Humans ; Immunity, Cellular ; Immunoenzyme Techniques ; Immunoglobulins - analysis ; Langerhans Cells - pathology ; Male ; Medical sciences ; Middle Aged ; Pityriasis - immunology ; Pityriasis - pathology ; Psoriasis. Parapsoriasis. Lichen ; T-Lymphocytes - classification ; T-Lymphocytes - pathology</subject><ispartof>Journal of the American Academy of Dermatology, 1984-05, Vol.10 (5), p.783-795</ispartof><rights>1984 American Academy of Dermatology Inc.</rights><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-d88e0ba4c4f65361d5430da870643fadce9dc0002ed7cbfa2aa1386dc5246e8b3</citedby><cites>FETCH-LOGICAL-c389t-d88e0ba4c4f65361d5430da870643fadce9dc0002ed7cbfa2aa1386dc5246e8b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0190-9622(84)70094-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9626443$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6373855$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Muhlbauer, Jan E.</creatorcontrib><creatorcontrib>Bhan, Atul K.</creatorcontrib><creatorcontrib>Harrist, Terence J.</creatorcontrib><creatorcontrib>Moscicki, Richard A.</creatorcontrib><creatorcontrib>Rand, Rhonda</creatorcontrib><creatorcontrib>Caughman, Wright</creatorcontrib><creatorcontrib>Loss, Bob</creatorcontrib><creatorcontrib>Mihm, Martin C.</creatorcontrib><title>Immunopathology of pityriasis lichenoides acuta</title><title>Journal of the American Academy of Dermatology</title><addtitle>J Am Acad Dermatol</addtitle><description>Eleven biopsy specimens (five papules and six dusky or crusted lesions) from four patients with pityriasis lichenoides et varioliformis acuta (PLEVA) were studied by direct immunofluorescence and immunoperoxidase technics. Slight vascular deposits of IgM and C3 were present in most lesions. Slight perivascular deposits of fibrin were observed in early lesions; more extensive perivascular and interstitial deposits of fibrin were detected in advanced lesions. Most of the infiltrating cells were T lymphocytes; cells with cytotoxic/suppressor phenotype (T8-positive) were generally more numerous than cells with helper/inducer phenotype (Leu-3a-positive, T4-positive). A marked increase in epidermal T8-positive cells over epidermal Leu-3a/T4-positive cells was found in late lesions. Moreover, a reduction of the ratio of circulating T4-positive to T8-positive cells was observed in most cases. The number of epidermal To-positive (Langerhans/indeterminate) cells was decreased in the lower as compared with the upper stratum spinosum. About 5% of perivascular infiltrating cells were T6-positive. These results suggest that cell-mediated immune mechanisms are probably important in the pathogenesis of PLEVA.</description><subject>Adult</subject><subject>Antibodies, Monoclonal - immunology</subject><subject>Biological and medical sciences</subject><subject>Complement C3 - analysis</subject><subject>Dermatology</subject><subject>Female</subject><subject>Fibrin - analysis</subject><subject>Flow Cytometry</subject><subject>Fluorescent Antibody Technique</subject><subject>Humans</subject><subject>Immunity, Cellular</subject><subject>Immunoenzyme Techniques</subject><subject>Immunoglobulins - analysis</subject><subject>Langerhans Cells - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pityriasis - immunology</subject><subject>Pityriasis - pathology</subject><subject>Psoriasis. Parapsoriasis. Lichen</subject><subject>T-Lymphocytes - classification</subject><subject>T-Lymphocytes - pathology</subject><issn>0190-9622</issn><issn>1097-6787</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtKAzEUhoMotVYfodCFiC7GJpPrrESKl0LBhboOaXLGRmYmNZkR-vZOL3Tr6iz-75zz8yE0JvieYCKm75gUOCtEnt8qdicxLlgmTtCQ4EJmQip5ioZH5BxdpPSNtxCVAzQQVFLF-RBN53XdNWFt2lWowtdmEsrJ2reb6E3yaVJ5u4ImeAdpYmzXmkt0VpoqwdVhjtDn89PH7DVbvL3MZ4-LzFJVtJlTCvDSMMtKwakgjjOKnVESC0ZL4ywUzvZ1cnDSLkuTG0OoEs7ynAlQSzpCN_u76xh-Okitrn2yUFWmgdAlrQiWknPeg3wP2hhSilDqdfS1iRtNsN6K0jtRemtBK6Z3orTo98aHB92yBnfcOpjp8-tDbpI1VRlNY306Yv05wRjtsYc9Br2MXw9RJ-uhseB8BNtqF_w_Rf4Ao2iE2Q</recordid><startdate>198405</startdate><enddate>198405</enddate><creator>Muhlbauer, Jan E.</creator><creator>Bhan, Atul K.</creator><creator>Harrist, Terence J.</creator><creator>Moscicki, Richard A.</creator><creator>Rand, Rhonda</creator><creator>Caughman, Wright</creator><creator>Loss, Bob</creator><creator>Mihm, Martin C.</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198405</creationdate><title>Immunopathology of pityriasis lichenoides acuta</title><author>Muhlbauer, Jan E. ; Bhan, Atul K. ; Harrist, Terence J. ; Moscicki, Richard A. ; Rand, Rhonda ; Caughman, Wright ; Loss, Bob ; Mihm, Martin C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-d88e0ba4c4f65361d5430da870643fadce9dc0002ed7cbfa2aa1386dc5246e8b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Adult</topic><topic>Antibodies, Monoclonal - immunology</topic><topic>Biological and medical sciences</topic><topic>Complement C3 - analysis</topic><topic>Dermatology</topic><topic>Female</topic><topic>Fibrin - analysis</topic><topic>Flow Cytometry</topic><topic>Fluorescent Antibody Technique</topic><topic>Humans</topic><topic>Immunity, Cellular</topic><topic>Immunoenzyme Techniques</topic><topic>Immunoglobulins - analysis</topic><topic>Langerhans Cells - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pityriasis - immunology</topic><topic>Pityriasis - pathology</topic><topic>Psoriasis. Parapsoriasis. Lichen</topic><topic>T-Lymphocytes - classification</topic><topic>T-Lymphocytes - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Muhlbauer, Jan E.</creatorcontrib><creatorcontrib>Bhan, Atul K.</creatorcontrib><creatorcontrib>Harrist, Terence J.</creatorcontrib><creatorcontrib>Moscicki, Richard A.</creatorcontrib><creatorcontrib>Rand, Rhonda</creatorcontrib><creatorcontrib>Caughman, Wright</creatorcontrib><creatorcontrib>Loss, Bob</creatorcontrib><creatorcontrib>Mihm, Martin C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Academy of Dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Muhlbauer, Jan E.</au><au>Bhan, Atul K.</au><au>Harrist, Terence J.</au><au>Moscicki, Richard A.</au><au>Rand, Rhonda</au><au>Caughman, Wright</au><au>Loss, Bob</au><au>Mihm, Martin C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunopathology of pityriasis lichenoides acuta</atitle><jtitle>Journal of the American Academy of Dermatology</jtitle><addtitle>J Am Acad Dermatol</addtitle><date>1984-05</date><risdate>1984</risdate><volume>10</volume><issue>5</issue><spage>783</spage><epage>795</epage><pages>783-795</pages><issn>0190-9622</issn><eissn>1097-6787</eissn><coden>JAADDB</coden><abstract>Eleven biopsy specimens (five papules and six dusky or crusted lesions) from four patients with pityriasis lichenoides et varioliformis acuta (PLEVA) were studied by direct immunofluorescence and immunoperoxidase technics. Slight vascular deposits of IgM and C3 were present in most lesions. Slight perivascular deposits of fibrin were observed in early lesions; more extensive perivascular and interstitial deposits of fibrin were detected in advanced lesions. Most of the infiltrating cells were T lymphocytes; cells with cytotoxic/suppressor phenotype (T8-positive) were generally more numerous than cells with helper/inducer phenotype (Leu-3a-positive, T4-positive). A marked increase in epidermal T8-positive cells over epidermal Leu-3a/T4-positive cells was found in late lesions. Moreover, a reduction of the ratio of circulating T4-positive to T8-positive cells was observed in most cases. The number of epidermal To-positive (Langerhans/indeterminate) cells was decreased in the lower as compared with the upper stratum spinosum. About 5% of perivascular infiltrating cells were T6-positive. These results suggest that cell-mediated immune mechanisms are probably important in the pathogenesis of PLEVA.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>6373855</pmid><doi>10.1016/S0190-9622(84)70094-6</doi><tpages>13</tpages></addata></record> |
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| ispartof | Journal of the American Academy of Dermatology, 1984-05, Vol.10 (5), p.783-795 |
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| subjects | Adult Antibodies, Monoclonal - immunology Biological and medical sciences Complement C3 - analysis Dermatology Female Fibrin - analysis Flow Cytometry Fluorescent Antibody Technique Humans Immunity, Cellular Immunoenzyme Techniques Immunoglobulins - analysis Langerhans Cells - pathology Male Medical sciences Middle Aged Pityriasis - immunology Pityriasis - pathology Psoriasis. Parapsoriasis. Lichen T-Lymphocytes - classification T-Lymphocytes - pathology |
| title | Immunopathology of pityriasis lichenoides acuta |
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