Nephrogenous Cyclic Adenosine Monophosphate Levels in Normocalcemic Cancer Patients: Its Significance
Summary We evaluated nephrogenous cyclic adenosine monophosphate (NcAMP) levels in 61 normocalcemic patients with documented cancer of various organs and cell types. NcAMP levels were elevated in 17 (28%) and decreased in 13 (21%) of the cancer patients. Both high and low NcAMP levels were seen with...
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| Veröffentlicht in: | Hormone and metabolic research 1984-04, Vol.16 (4), p.204-207 |
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| container_title | Hormone and metabolic research |
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| creator | Abramson, Edith C. Kukreja, S. C. Lad, T. E. Shemerdiak, W. P. York, Patricia A. J. |
| description | Summary
We evaluated nephrogenous cyclic adenosine monophosphate (NcAMP) levels in 61 normocalcemic patients with documented cancer of various organs and cell types. NcAMP levels were elevated in 17 (28%) and decreased in 13 (21%) of the cancer patients. Both high and low NcAMP levels were seen within the various cancer groups. There was a significant correlation (r = 0.383, P < 0.01) between NcAMP and serum parathyroid hormone (PTH) levels, suggesting that tumor-related factors affecting NcAMP. may be partially related to native PTH. Alternatively, these factors might be altering the effect of endogenous PTH on renal tubules. A significant negative correlation was also observed between NcAMP and tubular maximum for phosphate (r = -0.356, P < 0.02) suggesting that either cAMP per se or factors affecting NcAMP alter phosphate excretion. Follow up serum calcium data was available on 48 of the 61 patients. Subsequent hypercalcemia developed independent of the initial nephrogenous cAMP levels. It therefore appears that NcAMP elevation and development of hypercalcemia are two separate paraneoplastic phenomena. |
| doi_str_mv | 10.1055/s-2007-1014743 |
| format | Article |
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We evaluated nephrogenous cyclic adenosine monophosphate (NcAMP) levels in 61 normocalcemic patients with documented cancer of various organs and cell types. NcAMP levels were elevated in 17 (28%) and decreased in 13 (21%) of the cancer patients. Both high and low NcAMP levels were seen within the various cancer groups. There was a significant correlation (r = 0.383, P < 0.01) between NcAMP and serum parathyroid hormone (PTH) levels, suggesting that tumor-related factors affecting NcAMP. may be partially related to native PTH. Alternatively, these factors might be altering the effect of endogenous PTH on renal tubules. A significant negative correlation was also observed between NcAMP and tubular maximum for phosphate (r = -0.356, P < 0.02) suggesting that either cAMP per se or factors affecting NcAMP alter phosphate excretion. Follow up serum calcium data was available on 48 of the 61 patients. Subsequent hypercalcemia developed independent of the initial nephrogenous cAMP levels. It therefore appears that NcAMP elevation and development of hypercalcemia are two separate paraneoplastic phenomena.</description><identifier>ISSN: 0018-5043</identifier><identifier>EISSN: 1439-4286</identifier><identifier>DOI: 10.1055/s-2007-1014743</identifier><identifier>PMID: 6327481</identifier><identifier>CODEN: HMMRA2</identifier><language>eng</language><publisher>Stuttgart: Thieme</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Calcium - blood ; Cyclic AMP - metabolism ; Female ; General aspects ; Humans ; Kidney - metabolism ; Male ; Medical sciences ; Middle Aged ; Neoplasms - metabolism ; Parathyroid Hormone - blood ; Phosphates - metabolism ; Tumors</subject><ispartof>Hormone and metabolic research, 1984-04, Vol.16 (4), p.204-207</ispartof><rights>Georg Thieme Verlag, Stuttgart · New York</rights><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-aa2f5fe34458b56ea7d6058cd5e3ba890c4dfcbb09cbd9dd980c81cfc6993e683</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2007-1014743.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><link.rule.ids>314,780,784,3017,3018,27924,27925,54559</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9712992$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6327481$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abramson, Edith C.</creatorcontrib><creatorcontrib>Kukreja, S. C.</creatorcontrib><creatorcontrib>Lad, T. E.</creatorcontrib><creatorcontrib>Shemerdiak, W. P.</creatorcontrib><creatorcontrib>York, Patricia A. J.</creatorcontrib><title>Nephrogenous Cyclic Adenosine Monophosphate Levels in Normocalcemic Cancer Patients: Its Significance</title><title>Hormone and metabolic research</title><addtitle>Horm Metab Res</addtitle><description>Summary
We evaluated nephrogenous cyclic adenosine monophosphate (NcAMP) levels in 61 normocalcemic patients with documented cancer of various organs and cell types. NcAMP levels were elevated in 17 (28%) and decreased in 13 (21%) of the cancer patients. Both high and low NcAMP levels were seen within the various cancer groups. There was a significant correlation (r = 0.383, P < 0.01) between NcAMP and serum parathyroid hormone (PTH) levels, suggesting that tumor-related factors affecting NcAMP. may be partially related to native PTH. Alternatively, these factors might be altering the effect of endogenous PTH on renal tubules. A significant negative correlation was also observed between NcAMP and tubular maximum for phosphate (r = -0.356, P < 0.02) suggesting that either cAMP per se or factors affecting NcAMP alter phosphate excretion. Follow up serum calcium data was available on 48 of the 61 patients. Subsequent hypercalcemia developed independent of the initial nephrogenous cAMP levels. It therefore appears that NcAMP elevation and development of hypercalcemia are two separate paraneoplastic phenomena.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Calcium - blood</subject><subject>Cyclic AMP - metabolism</subject><subject>Female</subject><subject>General aspects</subject><subject>Humans</subject><subject>Kidney - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasms - metabolism</subject><subject>Parathyroid Hormone - blood</subject><subject>Phosphates - metabolism</subject><subject>Tumors</subject><issn>0018-5043</issn><issn>1439-4286</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEFv1DAQRi1EVZaWKzckHxC3FDu2E5tbtSpQaSlIlLPlOJOuq8QOnmyl_nu82qg3TqPR92ZG8wh5z9kVZ0p9xqpmrK0447KV4hXZcClMJWvdvCYbxriuFJPiDXmL-Fhaabg8J-eNqFup-YbAHcz7nB4gpgPS7bMfg6fXfWkxRKA_UkzzPuG8dwvQHTzBiDREepfylLwbPUyF37roIdNfbgkQF_xCbxekv8NDDEPwx-ySnA1uRHi31gvy5-vN_fZ7tfv57XZ7vau8UO1SOVcPagAhpdKdasC1fcOU9r0C0TltmJf94LuOGd_1pu-NZl5zP_jGGAGNFhfk02nvnNPfA-Bip4AextFFKP9ZzVlbt1wU8OoE-pwQMwx2zmFy-dlyZo9eLdqjV7t6LQMf1s2HboL-BV9FlvzjmjssXoZc3g74gpmW18bUBatO2LIPMIF9TIcci5H_nf0HpZGPjg</recordid><startdate>198404</startdate><enddate>198404</enddate><creator>Abramson, Edith C.</creator><creator>Kukreja, S. C.</creator><creator>Lad, T. E.</creator><creator>Shemerdiak, W. P.</creator><creator>York, Patricia A. J.</creator><general>Thieme</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198404</creationdate><title>Nephrogenous Cyclic Adenosine Monophosphate Levels in Normocalcemic Cancer Patients: Its Significance</title><author>Abramson, Edith C. ; Kukreja, S. C. ; Lad, T. E. ; Shemerdiak, W. P. ; York, Patricia A. J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-aa2f5fe34458b56ea7d6058cd5e3ba890c4dfcbb09cbd9dd980c81cfc6993e683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Calcium - blood</topic><topic>Cyclic AMP - metabolism</topic><topic>Female</topic><topic>General aspects</topic><topic>Humans</topic><topic>Kidney - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasms - metabolism</topic><topic>Parathyroid Hormone - blood</topic><topic>Phosphates - metabolism</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abramson, Edith C.</creatorcontrib><creatorcontrib>Kukreja, S. C.</creatorcontrib><creatorcontrib>Lad, T. E.</creatorcontrib><creatorcontrib>Shemerdiak, W. P.</creatorcontrib><creatorcontrib>York, Patricia A. J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hormone and metabolic research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abramson, Edith C.</au><au>Kukreja, S. C.</au><au>Lad, T. E.</au><au>Shemerdiak, W. P.</au><au>York, Patricia A. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nephrogenous Cyclic Adenosine Monophosphate Levels in Normocalcemic Cancer Patients: Its Significance</atitle><jtitle>Hormone and metabolic research</jtitle><addtitle>Horm Metab Res</addtitle><date>1984-04</date><risdate>1984</risdate><volume>16</volume><issue>4</issue><spage>204</spage><epage>207</epage><pages>204-207</pages><issn>0018-5043</issn><eissn>1439-4286</eissn><coden>HMMRA2</coden><abstract>Summary
We evaluated nephrogenous cyclic adenosine monophosphate (NcAMP) levels in 61 normocalcemic patients with documented cancer of various organs and cell types. NcAMP levels were elevated in 17 (28%) and decreased in 13 (21%) of the cancer patients. Both high and low NcAMP levels were seen within the various cancer groups. There was a significant correlation (r = 0.383, P < 0.01) between NcAMP and serum parathyroid hormone (PTH) levels, suggesting that tumor-related factors affecting NcAMP. may be partially related to native PTH. Alternatively, these factors might be altering the effect of endogenous PTH on renal tubules. A significant negative correlation was also observed between NcAMP and tubular maximum for phosphate (r = -0.356, P < 0.02) suggesting that either cAMP per se or factors affecting NcAMP alter phosphate excretion. Follow up serum calcium data was available on 48 of the 61 patients. Subsequent hypercalcemia developed independent of the initial nephrogenous cAMP levels. It therefore appears that NcAMP elevation and development of hypercalcemia are two separate paraneoplastic phenomena.</abstract><cop>Stuttgart</cop><cop>New York, NY</cop><pub>Thieme</pub><pmid>6327481</pmid><doi>10.1055/s-2007-1014743</doi><tpages>4</tpages></addata></record> |
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| source | MEDLINE; Thieme Connect Journals |
| subjects | Adult Aged Biological and medical sciences Calcium - blood Cyclic AMP - metabolism Female General aspects Humans Kidney - metabolism Male Medical sciences Middle Aged Neoplasms - metabolism Parathyroid Hormone - blood Phosphates - metabolism Tumors |
| title | Nephrogenous Cyclic Adenosine Monophosphate Levels in Normocalcemic Cancer Patients: Its Significance |
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