Human brain contains vasopressin and vasoactive intestinal polypeptide neuronal subpopulations in the suprachiasmatic region
The suprachiasmatic nuclei (SCN) and retinohypothalamic tract (RHT) in the anterior hypothalamus have been postulated to play an important role in the timing of daily biological rhythms in mammals. Although physiological studies have described circadian rhythms in man, the presence of an RHT or SCN...
Gespeichert in:
| Veröffentlicht in: | Brain research 1984-04, Vol.297 (1), p.159-163 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 163 |
|---|---|
| container_issue | 1 |
| container_start_page | 159 |
| container_title | Brain research |
| container_volume | 297 |
| creator | Stopa, Edward G. King, Joan C. Lydic, Ralph Schoene, William C. |
| description | The suprachiasmatic nuclei (SCN) and retinohypothalamic tract (RHT) in the anterior hypothalamus have been postulated to play an important role in the timing of daily biological rhythms in mammals. Although physiological studies have described circadian rhythms in man, the presence of an RHT or SCN has not been conclusively demonstrated in the human brain. Immunocytochemical identification of distinct ventral vasoactive intestinal polypeptide (VIP) containing and dorsal vasopressin containing neuronal subpopulations in the human suprachiasmatic region provides correlative evidence of neuronal clusters which are homologous to discrete cell groups in the SCN of other mammalian species. Manipulation of the circadian system has been used to treat some affective illnesses and othe physiological timing disorders. Characterization of the neural substrates underlying human circadian rhythms could be useful in the development of future treatment modalities and is essential for understanding normal human circadian organization. |
| doi_str_mv | 10.1016/0006-8993(84)90553-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_81071901</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0006899384905535</els_id><sourcerecordid>81071901</sourcerecordid><originalsourceid>FETCH-LOGICAL-c452t-7e10c653647df723bf61726d9bc43fe8de85d801fe9d77839b8dd86a19f62f753</originalsourceid><addsrcrecordid>eNp9kE9rFTEUxYNY6mv1GyjMQoouRpPJ5N9GkGJtoeBG1yGT3NjITDImMw8Kfvhm-h5v6epyz_ndw-Ug9JbgTwQT_hljzFupFP0g-48KM0Zb9gLtiBRdy7sev0S7E_IKXZTyp66UKnyOzjkVnerJDv27XScTmyGbEBub4lJnafampDlDKVU00T3vxi5hD02IC5QlRDM2cxofZ5iX4KCJsOa0iWUd5jSvo1lCqkk1YHmAqs7Z2IdgylQN22T4Xe3X6MybscCb47xEv26-_by-be9_fL-7_nrf2p51SyuAYMsZ5b1wXnR08JyIjjs12J56kA4kcxITD8oJIakapHOSG6I877xg9BJdHXLnnP6u9X09hWJhHE2EtBYtCRZEYVLB_gDanErJ4PWcw2TyoyZYb6XrrVG9Naplr59L11v-u2P-OkzgTkfHlqv__uibYs3os4k2lBOmOGOS0Yp9OWBQu9gHyLrYANGCCxnsol0K___jCfuyoUI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>81071901</pqid></control><display><type>article</type><title>Human brain contains vasopressin and vasoactive intestinal polypeptide neuronal subpopulations in the suprachiasmatic region</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Stopa, Edward G. ; King, Joan C. ; Lydic, Ralph ; Schoene, William C.</creator><creatorcontrib>Stopa, Edward G. ; King, Joan C. ; Lydic, Ralph ; Schoene, William C.</creatorcontrib><description>The suprachiasmatic nuclei (SCN) and retinohypothalamic tract (RHT) in the anterior hypothalamus have been postulated to play an important role in the timing of daily biological rhythms in mammals. Although physiological studies have described circadian rhythms in man, the presence of an RHT or SCN has not been conclusively demonstrated in the human brain. Immunocytochemical identification of distinct ventral vasoactive intestinal polypeptide (VIP) containing and dorsal vasopressin containing neuronal subpopulations in the human suprachiasmatic region provides correlative evidence of neuronal clusters which are homologous to discrete cell groups in the SCN of other mammalian species. Manipulation of the circadian system has been used to treat some affective illnesses and othe physiological timing disorders. Characterization of the neural substrates underlying human circadian rhythms could be useful in the development of future treatment modalities and is essential for understanding normal human circadian organization.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(84)90553-5</identifier><identifier>PMID: 6372941</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Afferent Pathways - physiology ; Biological and medical sciences ; Central nervous system ; Central neurotransmission. Neuromudulation. Pathways and receptors ; Circadian Rhythm ; circadian rhythms ; Fundamental and applied biological sciences. Psychology ; Humans ; Hypothalamus - physiology ; immunocytochemistry ; Immunoenzyme Techniques ; neuronal subpopulations ; Retina - physiology ; Sleep - physiology ; suprachiasmatic nuclei ; Suprachiasmatic Nucleus - cytology ; Suprachiasmatic Nucleus - metabolism ; Vasoactive Intestinal Peptide - metabolism ; vasoactive intestinal polypeptide ; vasopressin ; Vasopressins - metabolism ; Vertebrates: nervous system and sense organs</subject><ispartof>Brain research, 1984-04, Vol.297 (1), p.159-163</ispartof><rights>1984 Elsevier Science Publishers B.V., Amsterdam</rights><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-7e10c653647df723bf61726d9bc43fe8de85d801fe9d77839b8dd86a19f62f753</citedby><cites>FETCH-LOGICAL-c452t-7e10c653647df723bf61726d9bc43fe8de85d801fe9d77839b8dd86a19f62f753</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-8993(84)90553-5$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27911,27912,45982</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9655853$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6372941$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stopa, Edward G.</creatorcontrib><creatorcontrib>King, Joan C.</creatorcontrib><creatorcontrib>Lydic, Ralph</creatorcontrib><creatorcontrib>Schoene, William C.</creatorcontrib><title>Human brain contains vasopressin and vasoactive intestinal polypeptide neuronal subpopulations in the suprachiasmatic region</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>The suprachiasmatic nuclei (SCN) and retinohypothalamic tract (RHT) in the anterior hypothalamus have been postulated to play an important role in the timing of daily biological rhythms in mammals. Although physiological studies have described circadian rhythms in man, the presence of an RHT or SCN has not been conclusively demonstrated in the human brain. Immunocytochemical identification of distinct ventral vasoactive intestinal polypeptide (VIP) containing and dorsal vasopressin containing neuronal subpopulations in the human suprachiasmatic region provides correlative evidence of neuronal clusters which are homologous to discrete cell groups in the SCN of other mammalian species. Manipulation of the circadian system has been used to treat some affective illnesses and othe physiological timing disorders. Characterization of the neural substrates underlying human circadian rhythms could be useful in the development of future treatment modalities and is essential for understanding normal human circadian organization.</description><subject>Afferent Pathways - physiology</subject><subject>Biological and medical sciences</subject><subject>Central nervous system</subject><subject>Central neurotransmission. Neuromudulation. Pathways and receptors</subject><subject>Circadian Rhythm</subject><subject>circadian rhythms</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Hypothalamus - physiology</subject><subject>immunocytochemistry</subject><subject>Immunoenzyme Techniques</subject><subject>neuronal subpopulations</subject><subject>Retina - physiology</subject><subject>Sleep - physiology</subject><subject>suprachiasmatic nuclei</subject><subject>Suprachiasmatic Nucleus - cytology</subject><subject>Suprachiasmatic Nucleus - metabolism</subject><subject>Vasoactive Intestinal Peptide - metabolism</subject><subject>vasoactive intestinal polypeptide</subject><subject>vasopressin</subject><subject>Vasopressins - metabolism</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9rFTEUxYNY6mv1GyjMQoouRpPJ5N9GkGJtoeBG1yGT3NjITDImMw8Kfvhm-h5v6epyz_ndw-Ug9JbgTwQT_hljzFupFP0g-48KM0Zb9gLtiBRdy7sev0S7E_IKXZTyp66UKnyOzjkVnerJDv27XScTmyGbEBub4lJnafampDlDKVU00T3vxi5hD02IC5QlRDM2cxofZ5iX4KCJsOa0iWUd5jSvo1lCqkk1YHmAqs7Z2IdgylQN22T4Xe3X6MybscCb47xEv26-_by-be9_fL-7_nrf2p51SyuAYMsZ5b1wXnR08JyIjjs12J56kA4kcxITD8oJIakapHOSG6I877xg9BJdHXLnnP6u9X09hWJhHE2EtBYtCRZEYVLB_gDanErJ4PWcw2TyoyZYb6XrrVG9Naplr59L11v-u2P-OkzgTkfHlqv__uibYs3os4k2lBOmOGOS0Yp9OWBQu9gHyLrYANGCCxnsol0K___jCfuyoUI</recordid><startdate>19840409</startdate><enddate>19840409</enddate><creator>Stopa, Edward G.</creator><creator>King, Joan C.</creator><creator>Lydic, Ralph</creator><creator>Schoene, William C.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19840409</creationdate><title>Human brain contains vasopressin and vasoactive intestinal polypeptide neuronal subpopulations in the suprachiasmatic region</title><author>Stopa, Edward G. ; King, Joan C. ; Lydic, Ralph ; Schoene, William C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-7e10c653647df723bf61726d9bc43fe8de85d801fe9d77839b8dd86a19f62f753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Afferent Pathways - physiology</topic><topic>Biological and medical sciences</topic><topic>Central nervous system</topic><topic>Central neurotransmission. Neuromudulation. Pathways and receptors</topic><topic>Circadian Rhythm</topic><topic>circadian rhythms</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Hypothalamus - physiology</topic><topic>immunocytochemistry</topic><topic>Immunoenzyme Techniques</topic><topic>neuronal subpopulations</topic><topic>Retina - physiology</topic><topic>Sleep - physiology</topic><topic>suprachiasmatic nuclei</topic><topic>Suprachiasmatic Nucleus - cytology</topic><topic>Suprachiasmatic Nucleus - metabolism</topic><topic>Vasoactive Intestinal Peptide - metabolism</topic><topic>vasoactive intestinal polypeptide</topic><topic>vasopressin</topic><topic>Vasopressins - metabolism</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stopa, Edward G.</creatorcontrib><creatorcontrib>King, Joan C.</creatorcontrib><creatorcontrib>Lydic, Ralph</creatorcontrib><creatorcontrib>Schoene, William C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stopa, Edward G.</au><au>King, Joan C.</au><au>Lydic, Ralph</au><au>Schoene, William C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human brain contains vasopressin and vasoactive intestinal polypeptide neuronal subpopulations in the suprachiasmatic region</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1984-04-09</date><risdate>1984</risdate><volume>297</volume><issue>1</issue><spage>159</spage><epage>163</epage><pages>159-163</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>The suprachiasmatic nuclei (SCN) and retinohypothalamic tract (RHT) in the anterior hypothalamus have been postulated to play an important role in the timing of daily biological rhythms in mammals. Although physiological studies have described circadian rhythms in man, the presence of an RHT or SCN has not been conclusively demonstrated in the human brain. Immunocytochemical identification of distinct ventral vasoactive intestinal polypeptide (VIP) containing and dorsal vasopressin containing neuronal subpopulations in the human suprachiasmatic region provides correlative evidence of neuronal clusters which are homologous to discrete cell groups in the SCN of other mammalian species. Manipulation of the circadian system has been used to treat some affective illnesses and othe physiological timing disorders. Characterization of the neural substrates underlying human circadian rhythms could be useful in the development of future treatment modalities and is essential for understanding normal human circadian organization.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>6372941</pmid><doi>10.1016/0006-8993(84)90553-5</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-8993 |
| ispartof | Brain research, 1984-04, Vol.297 (1), p.159-163 |
| issn | 0006-8993 1872-6240 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_81071901 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Afferent Pathways - physiology Biological and medical sciences Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Circadian Rhythm circadian rhythms Fundamental and applied biological sciences. Psychology Humans Hypothalamus - physiology immunocytochemistry Immunoenzyme Techniques neuronal subpopulations Retina - physiology Sleep - physiology suprachiasmatic nuclei Suprachiasmatic Nucleus - cytology Suprachiasmatic Nucleus - metabolism Vasoactive Intestinal Peptide - metabolism vasoactive intestinal polypeptide vasopressin Vasopressins - metabolism Vertebrates: nervous system and sense organs |
| title | Human brain contains vasopressin and vasoactive intestinal polypeptide neuronal subpopulations in the suprachiasmatic region |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T19%3A15%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Human%20brain%20contains%20vasopressin%20and%20vasoactive%20intestinal%20polypeptide%20neuronal%20subpopulations%20in%20the%20suprachiasmatic%20region&rft.jtitle=Brain%20research&rft.au=Stopa,%20Edward%20G.&rft.date=1984-04-09&rft.volume=297&rft.issue=1&rft.spage=159&rft.epage=163&rft.pages=159-163&rft.issn=0006-8993&rft.eissn=1872-6240&rft.coden=BRREAP&rft_id=info:doi/10.1016/0006-8993(84)90553-5&rft_dat=%3Cproquest_cross%3E81071901%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=81071901&rft_id=info:pmid/6372941&rft_els_id=0006899384905535&rfr_iscdi=true |