CARDIOVASCULAR RESPONSIVENESS TO ARGININE VASOPRESSIN IN WATER-LOADED AND SODIUM-DEPLETED PREGNANT AND NON-PREGNANT SHEEP
SUMMARY 1. In conscious ewes pregnancy was associated with a significantly increased heart rate and cardiac output, while mean arterial pressure (MAP) and stroke volume were unchanged. 2. The present study examines the effect of arginine vasopressin (AVP) infused at 0.3, 1, 3.0, and 10 μg/h, into wa...
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| Veröffentlicht in: | Clinical and experimental pharmacology & physiology 1987-04, Vol.14 (4), p.319-326 |
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| container_title | Clinical and experimental pharmacology & physiology |
| container_volume | 14 |
| creator | Wintour, E. Marelyn Coghlan, John P. Congiu, Mario Grim, Clarence E. Laurence, Brenda M. Meehan, Peter J. McDougall, John G. Scoggins, Bruce A. |
| description | SUMMARY
1. In conscious ewes pregnancy was associated with a significantly increased heart rate and cardiac output, while mean arterial pressure (MAP) and stroke volume were unchanged.
2. The present study examines the effect of arginine vasopressin (AVP) infused at 0.3, 1, 3.0, and 10 μg/h, into water‐loaded and sodium‐depleted ewes, either non‐pregnant or during the last third of gestation.
3. In the water‐loaded state, MAP rose significantly at the lowest rate of infusion in both pregnant and non‐pregnant ewes. Bradycardia occurred first at 0.3 μg/h in the pregnant ewes but not until 3.0 μg/h in the non‐pregnant animals.
4. In sodium deficiency there was no increase in MAP at any rate of infusion in either group. Bradycardia occurred in both groups at 1 μg/h.
5. This study shows that the pressor effects of AVP are unchanged by pregnancy. However, pregnant ewes are more sensitive to AVP‐induced bradycardia when the ewes are water‐loaded. |
| doi_str_mv | 10.1111/j.1440-1681.1987.tb00977.x |
| format | Article |
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1. In conscious ewes pregnancy was associated with a significantly increased heart rate and cardiac output, while mean arterial pressure (MAP) and stroke volume were unchanged.
2. The present study examines the effect of arginine vasopressin (AVP) infused at 0.3, 1, 3.0, and 10 μg/h, into water‐loaded and sodium‐depleted ewes, either non‐pregnant or during the last third of gestation.
3. In the water‐loaded state, MAP rose significantly at the lowest rate of infusion in both pregnant and non‐pregnant ewes. Bradycardia occurred first at 0.3 μg/h in the pregnant ewes but not until 3.0 μg/h in the non‐pregnant animals.
4. In sodium deficiency there was no increase in MAP at any rate of infusion in either group. Bradycardia occurred in both groups at 1 μg/h.
5. This study shows that the pressor effects of AVP are unchanged by pregnancy. However, pregnant ewes are more sensitive to AVP‐induced bradycardia when the ewes are water‐loaded.</description><identifier>ISSN: 0305-1870</identifier><identifier>EISSN: 1440-1681</identifier><identifier>DOI: 10.1111/j.1440-1681.1987.tb00977.x</identifier><identifier>PMID: 3665197</identifier><identifier>CODEN: CEXPB9</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animals ; Arginine Vasopressin - blood ; Arginine Vasopressin - pharmacology ; AVP ; Biological and medical sciences ; blood pressure ; Blood Pressure - drug effects ; Cardiac Output - drug effects ; Female ; Fundamental and applied biological sciences. Psychology ; Heart Rate - drug effects ; Hemodynamics - drug effects ; Hormone metabolism and regulation ; Pregnancy ; Pregnancy, Animal - physiology ; Pregnancy. Parturition. Lactation ; Sheep ; Sodium - deficiency ; Vertebrates: reproduction ; Water-Electrolyte Imbalance - physiopathology</subject><ispartof>Clinical and experimental pharmacology & physiology, 1987-04, Vol.14 (4), p.319-326</ispartof><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3519-52d9dfe5f5ed9700fc172a0b9e90f93ad4997427a6133e997fb45605223c9bf93</citedby><cites>FETCH-LOGICAL-c3519-52d9dfe5f5ed9700fc172a0b9e90f93ad4997427a6133e997fb45605223c9bf93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1440-1681.1987.tb00977.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1440-1681.1987.tb00977.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7782941$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3665197$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wintour, E. Marelyn</creatorcontrib><creatorcontrib>Coghlan, John P.</creatorcontrib><creatorcontrib>Congiu, Mario</creatorcontrib><creatorcontrib>Grim, Clarence E.</creatorcontrib><creatorcontrib>Laurence, Brenda M.</creatorcontrib><creatorcontrib>Meehan, Peter J.</creatorcontrib><creatorcontrib>McDougall, John G.</creatorcontrib><creatorcontrib>Scoggins, Bruce A.</creatorcontrib><title>CARDIOVASCULAR RESPONSIVENESS TO ARGININE VASOPRESSIN IN WATER-LOADED AND SODIUM-DEPLETED PREGNANT AND NON-PREGNANT SHEEP</title><title>Clinical and experimental pharmacology & physiology</title><addtitle>Clin Exp Pharmacol Physiol</addtitle><description>SUMMARY
1. In conscious ewes pregnancy was associated with a significantly increased heart rate and cardiac output, while mean arterial pressure (MAP) and stroke volume were unchanged.
2. The present study examines the effect of arginine vasopressin (AVP) infused at 0.3, 1, 3.0, and 10 μg/h, into water‐loaded and sodium‐depleted ewes, either non‐pregnant or during the last third of gestation.
3. In the water‐loaded state, MAP rose significantly at the lowest rate of infusion in both pregnant and non‐pregnant ewes. Bradycardia occurred first at 0.3 μg/h in the pregnant ewes but not until 3.0 μg/h in the non‐pregnant animals.
4. In sodium deficiency there was no increase in MAP at any rate of infusion in either group. Bradycardia occurred in both groups at 1 μg/h.
5. This study shows that the pressor effects of AVP are unchanged by pregnancy. However, pregnant ewes are more sensitive to AVP‐induced bradycardia when the ewes are water‐loaded.</description><subject>Animals</subject><subject>Arginine Vasopressin - blood</subject><subject>Arginine Vasopressin - pharmacology</subject><subject>AVP</subject><subject>Biological and medical sciences</subject><subject>blood pressure</subject><subject>Blood Pressure - drug effects</subject><subject>Cardiac Output - drug effects</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Heart Rate - drug effects</subject><subject>Hemodynamics - drug effects</subject><subject>Hormone metabolism and regulation</subject><subject>Pregnancy</subject><subject>Pregnancy, Animal - physiology</subject><subject>Pregnancy. Parturition. Lactation</subject><subject>Sheep</subject><subject>Sodium - deficiency</subject><subject>Vertebrates: reproduction</subject><subject>Water-Electrolyte Imbalance - physiopathology</subject><issn>0305-1870</issn><issn>1440-1681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkFGvkzAYhhujOc6jP8GEGOMd2FKg1AsTAnWHOAsCO7tsCpSEyc6OdIvbv7c4wr1Nkzbf-3xvv74AfEDQQWZ93jvI86CNghA5iIbEOdUQUkKcywuwWqSXYAUx9G0UEvgavNF6DyH0YYDvwB0OAh9RsgLXOCqSNHuMyni7iQqrYGWe8TJ9ZJyVpVVlVlSsU55yZhkmy41eptwyexdVrLA3WZSwxIp4YpVZkm5_2AnLN6wyNcOuecSrfyLPuL0UygfG8rfgVScHrd7N5z3YfmNV_GAs12kcbewGmxFt321p2ym_81VLCYRdg4grYU0VhR3FsvUoJZ5LZIAwVube1Z4fQN91cUNrQ9yDTzff5_H4-6z0SRx63ahhkE_qeNYiRJCgABEDfrmBzXjUelSdeB77gxyvAkEx5S72YgpXTOGKKXcx5y4upvn9_Mq5Pqh2aZ2DNvrHWZe6kUM3yqem1wtGSOhSDxns6w370w_q-h8DiJjlGE2_tW8GvT6py2Igx18iIJj4YsfXYld9dwuvSsRP_BcoZ6RG</recordid><startdate>198704</startdate><enddate>198704</enddate><creator>Wintour, E. Marelyn</creator><creator>Coghlan, John P.</creator><creator>Congiu, Mario</creator><creator>Grim, Clarence E.</creator><creator>Laurence, Brenda M.</creator><creator>Meehan, Peter J.</creator><creator>McDougall, John G.</creator><creator>Scoggins, Bruce A.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198704</creationdate><title>CARDIOVASCULAR RESPONSIVENESS TO ARGININE VASOPRESSIN IN WATER-LOADED AND SODIUM-DEPLETED PREGNANT AND NON-PREGNANT SHEEP</title><author>Wintour, E. Marelyn ; Coghlan, John P. ; Congiu, Mario ; Grim, Clarence E. ; Laurence, Brenda M. ; Meehan, Peter J. ; McDougall, John G. ; Scoggins, Bruce A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3519-52d9dfe5f5ed9700fc172a0b9e90f93ad4997427a6133e997fb45605223c9bf93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Animals</topic><topic>Arginine Vasopressin - blood</topic><topic>Arginine Vasopressin - pharmacology</topic><topic>AVP</topic><topic>Biological and medical sciences</topic><topic>blood pressure</topic><topic>Blood Pressure - drug effects</topic><topic>Cardiac Output - drug effects</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Heart Rate - drug effects</topic><topic>Hemodynamics - drug effects</topic><topic>Hormone metabolism and regulation</topic><topic>Pregnancy</topic><topic>Pregnancy, Animal - physiology</topic><topic>Pregnancy. Parturition. Lactation</topic><topic>Sheep</topic><topic>Sodium - deficiency</topic><topic>Vertebrates: reproduction</topic><topic>Water-Electrolyte Imbalance - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wintour, E. Marelyn</creatorcontrib><creatorcontrib>Coghlan, John P.</creatorcontrib><creatorcontrib>Congiu, Mario</creatorcontrib><creatorcontrib>Grim, Clarence E.</creatorcontrib><creatorcontrib>Laurence, Brenda M.</creatorcontrib><creatorcontrib>Meehan, Peter J.</creatorcontrib><creatorcontrib>McDougall, John G.</creatorcontrib><creatorcontrib>Scoggins, Bruce A.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental pharmacology & physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wintour, E. Marelyn</au><au>Coghlan, John P.</au><au>Congiu, Mario</au><au>Grim, Clarence E.</au><au>Laurence, Brenda M.</au><au>Meehan, Peter J.</au><au>McDougall, John G.</au><au>Scoggins, Bruce A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CARDIOVASCULAR RESPONSIVENESS TO ARGININE VASOPRESSIN IN WATER-LOADED AND SODIUM-DEPLETED PREGNANT AND NON-PREGNANT SHEEP</atitle><jtitle>Clinical and experimental pharmacology & physiology</jtitle><addtitle>Clin Exp Pharmacol Physiol</addtitle><date>1987-04</date><risdate>1987</risdate><volume>14</volume><issue>4</issue><spage>319</spage><epage>326</epage><pages>319-326</pages><issn>0305-1870</issn><eissn>1440-1681</eissn><coden>CEXPB9</coden><abstract>SUMMARY
1. In conscious ewes pregnancy was associated with a significantly increased heart rate and cardiac output, while mean arterial pressure (MAP) and stroke volume were unchanged.
2. The present study examines the effect of arginine vasopressin (AVP) infused at 0.3, 1, 3.0, and 10 μg/h, into water‐loaded and sodium‐depleted ewes, either non‐pregnant or during the last third of gestation.
3. In the water‐loaded state, MAP rose significantly at the lowest rate of infusion in both pregnant and non‐pregnant ewes. Bradycardia occurred first at 0.3 μg/h in the pregnant ewes but not until 3.0 μg/h in the non‐pregnant animals.
4. In sodium deficiency there was no increase in MAP at any rate of infusion in either group. Bradycardia occurred in both groups at 1 μg/h.
5. This study shows that the pressor effects of AVP are unchanged by pregnancy. However, pregnant ewes are more sensitive to AVP‐induced bradycardia when the ewes are water‐loaded.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>3665197</pmid><doi>10.1111/j.1440-1681.1987.tb00977.x</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0305-1870 |
| ispartof | Clinical and experimental pharmacology & physiology, 1987-04, Vol.14 (4), p.319-326 |
| issn | 0305-1870 1440-1681 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_81071617 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Arginine Vasopressin - blood Arginine Vasopressin - pharmacology AVP Biological and medical sciences blood pressure Blood Pressure - drug effects Cardiac Output - drug effects Female Fundamental and applied biological sciences. Psychology Heart Rate - drug effects Hemodynamics - drug effects Hormone metabolism and regulation Pregnancy Pregnancy, Animal - physiology Pregnancy. Parturition. Lactation Sheep Sodium - deficiency Vertebrates: reproduction Water-Electrolyte Imbalance - physiopathology |
| title | CARDIOVASCULAR RESPONSIVENESS TO ARGININE VASOPRESSIN IN WATER-LOADED AND SODIUM-DEPLETED PREGNANT AND NON-PREGNANT SHEEP |
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