An unusual suppression of immune response: Pretreatment with poly(Glu 60,Phe 40) suppresses response to poly(Glu 60,Phe 40)

The synthetic random copolymer poly(Glu 60,Phe 40) (GPhe) is an excellent immunogen in SWR/J(H-2 q) mice. The intravenous injection of soluble GPhe by itself led to antibody production and GPhe-specific T-lymphocyte proliferation. The proliferating lymphocyte was sensitive to anti-Thy 1.2 and anti-L...

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