The air crescent sign of invasive pulmonary mucormycosis in acute leukemia
An unusual radiographic sign of crescentic cavitation appeared in a case of invasive pulmonary mucormycosis complicating the treatment of a patient with acute myelogenous leukemia and having a normal admission chest radiograph. The first manifestation was a large, wedge‐shaped pleural‐based consolid...
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| Veröffentlicht in: | Cancer 1984-06, Vol.53 (12), p.2721-2723 |
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| container_issue | 12 |
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| container_title | Cancer |
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| creator | Funada, Hisashi Misawa, Toshihiro Nakao, Shinji Saga, Tsutomu Hattori, Ken‐Ichi |
| description | An unusual radiographic sign of crescentic cavitation appeared in a case of invasive pulmonary mucormycosis complicating the treatment of a patient with acute myelogenous leukemia and having a normal admission chest radiograph. The first manifestation was a large, wedge‐shaped pleural‐based consolidation, which evolved about 10 days later into a fungus ball‐like lesion, usually known as the air crescent sign. Amphotericin B and 5‐fluorocytosine, which were initiated immediately after appearance of the sign, proved to be effective, probably in association with hematologic improvement. Transbronchial lung biopsy was not only helpful in establishing a definitive diagnosis, but also suggested that an intracavitary mass could have resulted from pulmonary infarction. This experience thus showed that the sign may appear in greater frequency in mucormycosis as well as in aspergillosis, and may be useful as a clinical index for initiating antifungal therapy in immunocompromised patients. |
| doi_str_mv | 10.1002/1097-0142(19840615)53:12<2721::AID-CNCR2820531228>3.0.CO;2-Y |
| format | Article |
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The first manifestation was a large, wedge‐shaped pleural‐based consolidation, which evolved about 10 days later into a fungus ball‐like lesion, usually known as the air crescent sign. Amphotericin B and 5‐fluorocytosine, which were initiated immediately after appearance of the sign, proved to be effective, probably in association with hematologic improvement. Transbronchial lung biopsy was not only helpful in establishing a definitive diagnosis, but also suggested that an intracavitary mass could have resulted from pulmonary infarction. 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Myelofibrosis ; Lung Diseases - diagnostic imaging ; Lung Diseases - etiology ; Male ; Medical sciences ; Mucormycosis - diagnostic imaging ; Mucormycosis - etiology ; Radiography</subject><ispartof>Cancer, 1984-06, Vol.53 (12), p.2721-2723</ispartof><rights>Copyright © 1984 American Cancer Society</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c5678-3cb61ec33e064be487bd1f83b627429933824c3c02ec7efba925f7a5086459d63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8869311$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6586275$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Funada, Hisashi</creatorcontrib><creatorcontrib>Misawa, Toshihiro</creatorcontrib><creatorcontrib>Nakao, Shinji</creatorcontrib><creatorcontrib>Saga, Tsutomu</creatorcontrib><creatorcontrib>Hattori, Ken‐Ichi</creatorcontrib><title>The air crescent sign of invasive pulmonary mucormycosis in acute leukemia</title><title>Cancer</title><addtitle>Cancer</addtitle><description>An unusual radiographic sign of crescentic cavitation appeared in a case of invasive pulmonary mucormycosis complicating the treatment of a patient with acute myelogenous leukemia and having a normal admission chest radiograph. The first manifestation was a large, wedge‐shaped pleural‐based consolidation, which evolved about 10 days later into a fungus ball‐like lesion, usually known as the air crescent sign. Amphotericin B and 5‐fluorocytosine, which were initiated immediately after appearance of the sign, proved to be effective, probably in association with hematologic improvement. Transbronchial lung biopsy was not only helpful in establishing a definitive diagnosis, but also suggested that an intracavitary mass could have resulted from pulmonary infarction. This experience thus showed that the sign may appear in greater frequency in mucormycosis as well as in aspergillosis, and may be useful as a clinical index for initiating antifungal therapy in immunocompromised patients.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Leukemia, Myeloid, Acute - complications</subject><subject>Leukemia, Myeloid, Acute - microbiology</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Lung Diseases - diagnostic imaging</subject><subject>Lung Diseases - etiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mucormycosis - diagnostic imaging</subject><subject>Mucormycosis - etiology</subject><subject>Radiography</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkF1rFDEYhYNY6tr6E4RciNiLWZM3k0xmFaFMrVaKC1LBgvCSyWZq7Hxsk53K_nuz7LqgF0KvQjhPDicPIWecTTlj8JqzssgYz-EVL3XOFJcnUsw4vIUC-Gx2enGWVZ-rL6CBScEB9DsxZdNq_gay60dksn_-mEwYYzqTufj2hDyN8We6FiDFITlUUiso5IR8uvrhqPGB2uCidf2KRn_T06Ghvr830d87uhzbbuhNWNNutEPo1naIPqacGjuuHG3deOs6b47JQWPa6J7tziPy9fz9VfUxu5x_uKhOLzMrVaEzYWvFnRXCMZXXLtdFveCNFnUalENZCqEht8IycLZwTW1KkE1hJNMql-VCiSPyctu7DMPd6OIKO5-mt63p3TBG1JwprRkk8PsWtGGIMbgGl8F36SPIGW5U48YVblzhH9UoBXLAjWrEpBr_Vo0CGVZzBLxO9c93O8a6c4t9-c5tyl_schOtaZtgeuvjHtNalYLzhN1ssV--desHTvzvwn8S8RtnFahz</recordid><startdate>19840615</startdate><enddate>19840615</enddate><creator>Funada, Hisashi</creator><creator>Misawa, Toshihiro</creator><creator>Nakao, Shinji</creator><creator>Saga, Tsutomu</creator><creator>Hattori, Ken‐Ichi</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19840615</creationdate><title>The air crescent sign of invasive pulmonary mucormycosis in acute leukemia</title><author>Funada, Hisashi ; Misawa, Toshihiro ; Nakao, Shinji ; Saga, Tsutomu ; Hattori, Ken‐Ichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5678-3cb61ec33e064be487bd1f83b627429933824c3c02ec7efba925f7a5086459d63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Leukemia, Myeloid, Acute - complications</topic><topic>Leukemia, Myeloid, Acute - microbiology</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Lung Diseases - diagnostic imaging</topic><topic>Lung Diseases - etiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mucormycosis - diagnostic imaging</topic><topic>Mucormycosis - etiology</topic><topic>Radiography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Funada, Hisashi</creatorcontrib><creatorcontrib>Misawa, Toshihiro</creatorcontrib><creatorcontrib>Nakao, Shinji</creatorcontrib><creatorcontrib>Saga, Tsutomu</creatorcontrib><creatorcontrib>Hattori, Ken‐Ichi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Funada, Hisashi</au><au>Misawa, Toshihiro</au><au>Nakao, Shinji</au><au>Saga, Tsutomu</au><au>Hattori, Ken‐Ichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The air crescent sign of invasive pulmonary mucormycosis in acute leukemia</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>1984-06-15</date><risdate>1984</risdate><volume>53</volume><issue>12</issue><spage>2721</spage><epage>2723</epage><pages>2721-2723</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><coden>CANCAR</coden><abstract>An unusual radiographic sign of crescentic cavitation appeared in a case of invasive pulmonary mucormycosis complicating the treatment of a patient with acute myelogenous leukemia and having a normal admission chest radiograph. The first manifestation was a large, wedge‐shaped pleural‐based consolidation, which evolved about 10 days later into a fungus ball‐like lesion, usually known as the air crescent sign. Amphotericin B and 5‐fluorocytosine, which were initiated immediately after appearance of the sign, proved to be effective, probably in association with hematologic improvement. Transbronchial lung biopsy was not only helpful in establishing a definitive diagnosis, but also suggested that an intracavitary mass could have resulted from pulmonary infarction. This experience thus showed that the sign may appear in greater frequency in mucormycosis as well as in aspergillosis, and may be useful as a clinical index for initiating antifungal therapy in immunocompromised patients.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>6586275</pmid><doi>10.1002/1097-0142(19840615)53:12<2721::AID-CNCR2820531228>3.0.CO;2-Y</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Cancer, 1984-06, Vol.53 (12), p.2721-2723 |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Biological and medical sciences Hematologic and hematopoietic diseases Humans Leukemia, Myeloid, Acute - complications Leukemia, Myeloid, Acute - microbiology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lung Diseases - diagnostic imaging Lung Diseases - etiology Male Medical sciences Mucormycosis - diagnostic imaging Mucormycosis - etiology Radiography |
| title | The air crescent sign of invasive pulmonary mucormycosis in acute leukemia |
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