Plasma Concentrations of Thiothixene and Clinical Response in Treatment-Resistant Schizophrenics
Plasma concentrations of thiothixene were measured during treatment of 42 treatment-resistant schizophrenic patients. Inter-individual variability was marked even when patients were treated with the same dose or dose regimen. Intra-individual variability was less but still considerable. A highly sig...
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| Veröffentlicht in: | International clinical psychopharmacology 1987-01, Vol.2 (1), p.77-82 |
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| container_title | International clinical psychopharmacology |
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| creator | HOLLISTER, LEO E LOMBROZO, LEON HUANG, CHUONG C |
| description | Plasma concentrations of thiothixene were measured during treatment of 42 treatment-resistant schizophrenic patients. Inter-individual variability was marked even when patients were treated with the same dose or dose regimen. Intra-individual variability was less but still considerable. A highly significant correlation was found between dose and plasma concentration, but this relationship was unpredictable for individual patients. A median plasma concentration of 12 to 15 ng/ml might be expected with daily doses of 60 mg. No definite range of therapeutic plasma concentrations could be determined. Patients who attained moderate degrees of improvement did so at a median dose of 26 ng/ml, which is within the range of therapeutic plasma concentrations previously reported for thiothixene in similar patients. |
| doi_str_mv | 10.1097/00004850-198701000-00007 |
| format | Article |
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Inter-individual variability was marked even when patients were treated with the same dose or dose regimen. Intra-individual variability was less but still considerable. A highly significant correlation was found between dose and plasma concentration, but this relationship was unpredictable for individual patients. A median plasma concentration of 12 to 15 ng/ml might be expected with daily doses of 60 mg. No definite range of therapeutic plasma concentrations could be determined. Patients who attained moderate degrees of improvement did so at a median dose of 26 ng/ml, which is within the range of therapeutic plasma concentrations previously reported for thiothixene in similar patients.</description><identifier>ISSN: 0268-1315</identifier><identifier>EISSN: 1473-5857</identifier><identifier>DOI: 10.1097/00004850-198701000-00007</identifier><identifier>PMID: 3312399</identifier><language>eng</language><publisher>England: Lippincott-Raven Publishers</publisher><subject>Adult ; Chronic Disease ; Clinical Trials as Topic ; Dose-Response Relationship, Drug ; Double-Blind Method ; Female ; Humans ; Male ; Middle Aged ; Radioligand Assay ; Random Allocation ; Schizophrenia - blood ; Schizophrenia - drug therapy ; Schizophrenic Psychology ; Thiothixene - pharmacokinetics ; Thiothixene - therapeutic use</subject><ispartof>International clinical psychopharmacology, 1987-01, Vol.2 (1), p.77-82</ispartof><rights>Lippincott-Raven Publishers.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3312399$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HOLLISTER, LEO E</creatorcontrib><creatorcontrib>LOMBROZO, LEON</creatorcontrib><creatorcontrib>HUANG, CHUONG C</creatorcontrib><title>Plasma Concentrations of Thiothixene and Clinical Response in Treatment-Resistant Schizophrenics</title><title>International clinical psychopharmacology</title><addtitle>Int Clin Psychopharmacol</addtitle><description>Plasma concentrations of thiothixene were measured during treatment of 42 treatment-resistant schizophrenic patients. Inter-individual variability was marked even when patients were treated with the same dose or dose regimen. Intra-individual variability was less but still considerable. A highly significant correlation was found between dose and plasma concentration, but this relationship was unpredictable for individual patients. A median plasma concentration of 12 to 15 ng/ml might be expected with daily doses of 60 mg. No definite range of therapeutic plasma concentrations could be determined. Patients who attained moderate degrees of improvement did so at a median dose of 26 ng/ml, which is within the range of therapeutic plasma concentrations previously reported for thiothixene in similar patients.</description><subject>Adult</subject><subject>Chronic Disease</subject><subject>Clinical Trials as Topic</subject><subject>Dose-Response Relationship, Drug</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Radioligand Assay</subject><subject>Random Allocation</subject><subject>Schizophrenia - blood</subject><subject>Schizophrenia - drug therapy</subject><subject>Schizophrenic Psychology</subject><subject>Thiothixene - pharmacokinetics</subject><subject>Thiothixene - therapeutic use</subject><issn>0268-1315</issn><issn>1473-5857</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UU1PAyEQJUaj9eMnmHDytgrLboGjafxKTDRaz8jSaRZloQJN1V8v2urNuUzmzXszkzcIYUpOKZH8jJRoREsqKgUntFTVN8S30Ig2nFWtaPk2GpF6LCrKaLuH9lN6IaQmVDa7aJcxWjMpR-j53uk0aDwJ3oDPUWcbfMJhjqe9Dbm37-ABaz_DE2e9NdrhB0iLwgFsPZ5G0HkowqqgNmXtM340vf0Miz5C4adDtDPXLsHRJh-gp8uL6eS6ur27upmc31aGlbsrSjuYjRvJdA2Ucd7Jls2EELXuuo4TrYG2shsDa-YajDCmpsJwTgQXjLeSsQN0sp67iOFtCSmrwSYDzmkPYZmUoGTccikLUayJJoaUIszVItpBxw9Fifo2V_2aq_7M_YF4kR5vdiy7AWZ_wo2bpd-s-6vgMsT06pYriKoH7XKv_vsZ-wJW34VK</recordid><startdate>198701</startdate><enddate>198701</enddate><creator>HOLLISTER, LEO E</creator><creator>LOMBROZO, LEON</creator><creator>HUANG, CHUONG C</creator><general>Lippincott-Raven Publishers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198701</creationdate><title>Plasma Concentrations of Thiothixene and Clinical Response in Treatment-Resistant Schizophrenics</title><author>HOLLISTER, LEO E ; LOMBROZO, LEON ; HUANG, CHUONG C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3007-11bed6493a2e1377b953d8882abbb70aae159b6e34faec8cc218c770878375933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Adult</topic><topic>Chronic Disease</topic><topic>Clinical Trials as Topic</topic><topic>Dose-Response Relationship, Drug</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Radioligand Assay</topic><topic>Random Allocation</topic><topic>Schizophrenia - blood</topic><topic>Schizophrenia - drug therapy</topic><topic>Schizophrenic Psychology</topic><topic>Thiothixene - pharmacokinetics</topic><topic>Thiothixene - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HOLLISTER, LEO E</creatorcontrib><creatorcontrib>LOMBROZO, LEON</creatorcontrib><creatorcontrib>HUANG, CHUONG C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International clinical psychopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HOLLISTER, LEO E</au><au>LOMBROZO, LEON</au><au>HUANG, CHUONG C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma Concentrations of Thiothixene and Clinical Response in Treatment-Resistant Schizophrenics</atitle><jtitle>International clinical psychopharmacology</jtitle><addtitle>Int Clin Psychopharmacol</addtitle><date>1987-01</date><risdate>1987</risdate><volume>2</volume><issue>1</issue><spage>77</spage><epage>82</epage><pages>77-82</pages><issn>0268-1315</issn><eissn>1473-5857</eissn><abstract>Plasma concentrations of thiothixene were measured during treatment of 42 treatment-resistant schizophrenic patients. 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| ispartof | International clinical psychopharmacology, 1987-01, Vol.2 (1), p.77-82 |
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| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Chronic Disease Clinical Trials as Topic Dose-Response Relationship, Drug Double-Blind Method Female Humans Male Middle Aged Radioligand Assay Random Allocation Schizophrenia - blood Schizophrenia - drug therapy Schizophrenic Psychology Thiothixene - pharmacokinetics Thiothixene - therapeutic use |
| title | Plasma Concentrations of Thiothixene and Clinical Response in Treatment-Resistant Schizophrenics |
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